HV - Master i Biomedisin: Nye registreringer
Viser treff 21-40 av 89
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Establishment and characterization of cell lines to study the proxymitome of the Centrosome and Spindle Pole-associated protein 1
(Master thesis, 2021)The predominantly expressed isoform of CSPP1, CSPP-L, is a centrosomal and Centriolar satellite protein with functions in microtubule organization in cell division and cilia formation. CSPP-L dose and microtubule organizing ... -
Change in content of extracellular vesicles from human skeletal muscle cells after electrical pulse stimulation with focus on microRNA.
(Master thesis, 2021)Background and Aim Extracellular vesicles (EVs) are nanoparticles with a double membrane postulated to be released by cells of all types and can be detected in all body fluids. They are classified in three groups ... -
Synthesis and LC-MS Analysis of Cinchona Derivatives
(Master thesis, 2021)Cinchona alkaloids with their main component Quinine, are isolated from the barks of several species of cinchona trees and have been used in medicine for over 400 years mainly as anti-malarial medication. These natural ... -
Optimizing DNA Extraction from Dried Blood Spots for Biological Age Measurements
(Master thesis, 2021)While the chronological age is the time that has passed since birth, the biological age is determined by physiological signs of aging. Methylation at CpG sites has proven to be a promising biomarker of biological age, and ... -
Optimalisering av FDG- PET/CT for pasienter med lymfekreft
(Master thesis, 2021)Sammendrag Bakgrunn Positronemisjonstomografi (PET) med 18-F fluorodeoksyglukose (FDG), integrert med computertomografi (CT)- (18F- FDG- PET / CT) blir i økende grad brukt til klassifisering og i oppfølgingsvurderingen ... -
Effects of bromodomain or androgen-receptor inhibitors in combination with radiopharmaceuticals in castration-resistant prostate cancer cell monolayers and multicellular spheroids
(Master thesis, 2021)Background: Prostate cancer not responding to androgen deprivation therapy is known as castration-resistant prostate cancer (CRPC). Despite rapid increase of treatment options, the disease remains incurable, when metastases ... -
Behandling av Nevroendokrine Tumorer med 177Lu-DOTATATE - Fra Pasientens Perspektiv
(Master thesis, 2021)I 2020 ble det på bakgrunn av en internasjonal beslutning innført peptidreseptor-nuklideterapi med 177Lu-DOTATATE ved fire norske sykehus, som et behandlingsalternativ for pasienter med nevroendokrine tumorer (NETs). For ... -
A study of quantitative and qualitative performance of metabolomics compared with targeted analyses used in laboratory diagnostics
(Master thesis, 2021)Today, several specific and targeted analyses are used for detection of different chemical compounds and diagnostics of inborn errors of metabolism (IEMs). Metabolomics, an untargeted analytical approach, has been used as ... -
Difference between volume Computed Tomography Dose Index (CTDIvol) and Size Specific Dose Estimates (SSDE) in abdomen- and thorax protocols in patients of different sizes in different CT scanners.
(Master thesis, 2021)Background: Volume Computed Tomography Dose Index (CTDIvol) only provides information about the radiation dose delivered by a CT scanner. The Size Specific Dose Estimate (SSDE) introduced by the American Association of ... -
Undersøkelse av autofagi-nivåer i cellemodeller for dannelse og progresjon av prostatakreft
(Master thesis, 2021)Bakgrunn og formål Eksisterende forskning gir ingen klare svar på om autofagi opp- eller nedreguleres i cellens utvikling fra en normal celle til en aggressiv og metastaserende kreftcelle. I mangel på forskning med metoder ... -
Klinisk betydning av automatisk varsling av blaster på hematologiinstrument
(Master thesis, 2021)Bakgrunn og formål Blaster er umodne blodceller som vanligvis finnes i beinmargen, men som ved ulike sykdommer og tilstander kan finnes i perifert blod, for eksempel leukemier. Ved differensialtelling av leukocytter på ... -
Exploring changes in long non-coding RNAs during neonatal hypoxia-ischemia using a piglet model
(Master thesis, 2021)Background: Despite major advances in research and clinical care during the last decade, hypoxic-ischemic encephalopathy (HIE) remains one of the leading causes worldwide of death and disability in children under five years ... -
Establishment of a new quantitative method for in situ detection of DNA breaks in human spermatozoa
(Master thesis, 2021)Background: There is increasing evidence that infertile men have higher levels of DNA fragmentation compared to fertile men. It was also shown that spermatozoa with highly fragmented DNA are less motile. Several tests are ... -
Migration of prostate cancer cells along neurite outgrowths: optimalization of experimental conditions and characterization of nerve-cancer co-cultures
(Master thesis, 2021)As approximately 5000 males are diagnosed with prostate cancer every year in Norway, prostate cancer persists as a medical issue today. It is shown that tumor innervation is important for development and progression of the ... -
HPV chromosomal integration as a biomarker for cancer progression
(Master thesis, 2021)Background: Human papillomavirus (HPV) is associated with 4,5% of all human cancers worldwide including cervical cancer. Cytological and/or HPV primary screening is used to uncover cancer precursors. Still, better clinical ... -
Effekt av kortkjedede fettsyrer og forgreinede fettsyrer på energimetabolisme i skjelettmuskelceller
(Master thesis, 2021)Innledning: I det siste har det vært stor fokus på sammenheng mellom tarmflora og etiologien av metabolske sykdommer som fedme og type 2-diabetes. Tarmflora kan spille en viktig rolle i energimetabolisme ved blant annet ... -
Deep inspiration breath-hold in stereotactic and conventional fractionated radiotherapy of lesions in the lung
(Master thesis, 2021)The purpose of the clinical study was to evaluate lung cancer patients’ ability to perform deep inspiration breath-hold (DIBH) during CT simulation and throughout the treatment course of radiation therapy (RT). In addition, ... -
Identification and characterization of human branched-chain amino acid transaminase 1 inhibitors
(Master thesis, 2021)Branched-chain amino acid transaminase 1 (BCAT1) is a protein known to be upregulated in severe cancers such as brain-, pancreatic-, and breast cancer, as well as in the neurodegenerative Alzheimer’s disease. Via structural-, ... -
Investigation of the expression profile of miRNAs regulating ADHD candidate genes
(Master thesis, 2021)Attention-deficit/hyperactivity disorder (ADHD) er den vanligste nevropsykologiske forstyrrelsen ved barndom, preget av symptomer som uoppmerksomhet og hyperaktivitet/impulsivitet i varierende alvorlighetsgrad på tvers ... -
KRAS-genmutasjonsanalyse som førstevalg innen molekylærdiagnostikk ved adenokarsinom i lunge
(MABIOD;2020, Master thesis, 2020)Lungekreft er kreftformen med høyest dødelighet i Norge. Behandlingsmulighetene har tidligere vært kirurgi, stråling og cellegift. De senere år har ny behandling i form av immunterapi og målrettet behandling mot genmutasjoner ...