HV - Master i Biomedisin
Recent Submissions
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Cytokinprofil i kolorektale tumorer - med og uten Fusobacterium nucleatum
(Master thesis, 2021)Bakgrunn og formål: Den vanlige oppfatningen er at inflammasjon i kolorektal kreft (CRC) er et resultat av den neoplastiske celleveksten. Det er vist at epitelbarrieren mot tarmlumen kan være svekket i kolorektale ... -
Investigation of the expression profile of miRNAs regulating ADHD candidate genes.
(Master thesis, 2021)Attention-deficit/hyperactivity disorder (ADHD) is the most common child-hood onset neuropsychological disorder, characterized by symptoms such as inattention and hyperactivity/impulsivity in varying severity across ... -
Effects of polycyclic aromatic hydrocarbons (PAHs) on cell viability and gene expression related to neurite outgrowth in human neural stem cells undergoing differentiation
(Master thesis, 2021)Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental pollutants formed under incomplete combustions of organic materials such as the burning of fossil fuels, domestic heating, automobile exhaust, cooking, ... -
Development of a liquid chromatography-tandem mass spectrometry analysis for cortisol as a stress biomarker to monitor fish welfare
(Master thesis, 2021)Background: Norway is the world’s biggest salmon producer and the salmon industry has grown to become Norway’s second largest export industry in value, after oil and gas. Despite the impressive growth, the industry is still ... -
Establishment and characterization of cell lines to study the proxymitome of the Centrosome and Spindle Pole-associated protein 1
(Master thesis, 2021)The predominantly expressed isoform of CSPP1, CSPP-L, is a centrosomal and Centriolar satellite protein with functions in microtubule organization in cell division and cilia formation. CSPP-L dose and microtubule organizing ... -
Change in content of extracellular vesicles from human skeletal muscle cells after electrical pulse stimulation with focus on microRNA.
(Master thesis, 2021)Background and Aim Extracellular vesicles (EVs) are nanoparticles with a double membrane postulated to be released by cells of all types and can be detected in all body fluids. They are classified in three groups ... -
Synthesis and LC-MS Analysis of Cinchona Derivatives
(Master thesis, 2021)Cinchona alkaloids with their main component Quinine, are isolated from the barks of several species of cinchona trees and have been used in medicine for over 400 years mainly as anti-malarial medication. These natural ... -
Optimizing DNA Extraction from Dried Blood Spots for Biological Age Measurements
(Master thesis, 2021)While the chronological age is the time that has passed since birth, the biological age is determined by physiological signs of aging. Methylation at CpG sites has proven to be a promising biomarker of biological age, and ... -
Cytokinprofil i kolorektale tumorer - med og uten Fusobacterium nucleatum
(Master thesis, 2021)Den vanlige oppfatningen er at inflammasjon i kolorektal kreft (CRC) er et resultat av den neoplastiske celleveksten. Det er vist at epitelbarrieren mot tarmlumen kan være svekket i kolorektale tumorer, dette kan føre til ... -
Optimalisering av FDG- PET/CT for pasienter med lymfekreft
(Master thesis, 2021)Sammendrag Bakgrunn Positronemisjonstomografi (PET) med 18-F fluorodeoksyglukose (FDG), integrert med computertomografi (CT)- (18F- FDG- PET / CT) blir i økende grad brukt til klassifisering og i oppfølgingsvurderingen ... -
Effects of bromodomain or androgen-receptor inhibitors in combination with radiopharmaceuticals in castration-resistant prostate cancer cell monolayers and multicellular spheroids
(Master thesis, 2021)Background: Prostate cancer not responding to androgen deprivation therapy is known as castration-resistant prostate cancer (CRPC). Despite rapid increase of treatment options, the disease remains incurable, when metastases ... -
Behandling av Nevroendokrine Tumorer med 177Lu-DOTATATE - Fra Pasientens Perspektiv
(Master thesis, 2021)I 2020 ble det på bakgrunn av en internasjonal beslutning innført peptidreseptor-nuklideterapi med 177Lu-DOTATATE ved fire norske sykehus, som et behandlingsalternativ for pasienter med nevroendokrine tumorer (NETs). For ... -
A study of quantitative and qualitative performance of metabolomics compared with targeted analyses used in laboratory diagnostics
(Master thesis, 2021)Today, several specific and targeted analyses are used for detection of different chemical compounds and diagnostics of inborn errors of metabolism (IEMs). Metabolomics, an untargeted analytical approach, has been used as ... -
Difference between volume Computed Tomography Dose Index (CTDIvol) and Size Specific Dose Estimates (SSDE) in abdomen- and thorax protocols in patients of different sizes in different CT scanners.
(Master thesis, 2021)Background: Volume Computed Tomography Dose Index (CTDIvol) only provides information about the radiation dose delivered by a CT scanner. The Size Specific Dose Estimate (SSDE) introduced by the American Association of ... -
Undersøkelse av autofagi-nivåer i cellemodeller for dannelse og progresjon av prostatakreft
(Master thesis, 2021)Bakgrunn og formål Eksisterende forskning gir ingen klare svar på om autofagi opp- eller nedreguleres i cellens utvikling fra en normal celle til en aggressiv og metastaserende kreftcelle. I mangel på forskning med metoder ... -
Klinisk betydning av automatisk varsling av blaster på hematologiinstrument
(Master thesis, 2021)Bakgrunn og formål Blaster er umodne blodceller som vanligvis finnes i beinmargen, men som ved ulike sykdommer og tilstander kan finnes i perifert blod, for eksempel leukemier. Ved differensialtelling av leukocytter på ... -
Exploring changes in long non-coding RNAs during neonatal hypoxia-ischemia using a piglet model
(Master thesis, 2021)Background: Despite major advances in research and clinical care during the last decade, hypoxic-ischemic encephalopathy (HIE) remains one of the leading causes worldwide of death and disability in children under five years ... -
Establishment of a new quantitative method for in situ detection of DNA breaks in human spermatozoa
(Master thesis, 2021)Background: There is increasing evidence that infertile men have higher levels of DNA fragmentation compared to fertile men. It was also shown that spermatozoa with highly fragmented DNA are less motile. Several tests are ... -
Migration of prostate cancer cells along neurite outgrowths: optimalization of experimental conditions and characterization of nerve-cancer co-cultures
(Master thesis, 2021)As approximately 5000 males are diagnosed with prostate cancer every year in Norway, prostate cancer persists as a medical issue today. It is shown that tumor innervation is important for development and progression of the ... -
General control nonderepressible two (GCN2) as a therapeutic target for prostate cancer
(Master thesis, 2021)Prostate cancer (PC) is the second most common cancer in men worldwide. Primary PC is treated by surgery, radiotherapy or high dose-rate brachytherapy and androgen deprivation therapy (ADT) – and this is usually very ...
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