HV - Master i Biomedisin
Recent Submissions
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Optimizing DNA Extraction from Dried Blood Spots for Biological Age Measurements
(Master thesis, 2021-05)While the chronological age is the time that has passed since birth, the biological age is determined by physiological signs of aging. Methylation at CpG sites has proven to be a promising biomarker of biological age, and ... -
Change in content of extracellular vesicles from human skeletal muscle cells after electrical pulse stimulation with focus on microRNA.
(Master thesis, 2021-05)3.1 Background and Aim Extracellular vesicles (EVs) are nanoparticles with a double membrane postulated to be released by cells of all types and can be detected in all body fluids. They are classified in three groups ... -
Synthesis and LC-MS Analysis of Cinchona Derivatives
(Master thesis, 2021)Cinchona alkaloids with their main component Quinine, are isolated from the barks of several species of cinchona trees and have been used in medicine for over 400 years mainly as anti-malarial medication. These natural ... -
"HPV chromosomal integration as a biomarker for cancer progression" Validation and characterization of integration sites in HPV31, 33 and 45 positive cervical samples
(Master thesis, 2021-05)Background: Human papillomavirus (HPV) is associated with 4.5% of all human cancers worldwide including cervical cancer. Cytological and/or HPV primary screening is used to uncover cancer precursors. Still, better clinical ... -
Deep inspiration breath-hold in stereotactic and conventional fractionated radiotherapy of lesions in the lung
(Master thesis, 2021-05)The purpose of the clinical study was to evaluate lung cancer patients’ ability to perform deep inspiration breath-hold (DIBH) during CT simulation and throughout the treatment course of radiation therapy (RT). In addition, ... -
Optimalisering av FDG- PET/CT for pasienter med lymfom
(Master thesis, 2021-05)Bakgrunn Positronemisjonstomografi (PET) med 18-F fluorodeoksyglukose (FDG), integrert med computertomografi (CT)- (18F- FDG- PET / CT) blir i økende grad brukt til klassifisering og i oppfølgingsvurderingen av behandlingsrespons ... -
EXPLORING CHANGES IN LONG NON-CODING RNAS DURING NEONATAL HYPOXIA-ISCHEMIA USING A PIGLET MODEL
(Master thesis, 2021-05)Background: Despite major advances in research and clinical care during the last decade, hypoxic-ischemic encephalopathy (HIE) remains one of the leading causes worldwide of death and disability in children under five years ... -
A study of quantitative and qualitative performance of metabolomics compared with targeted analyses used in laboratory diagnostics
(Master thesis, 2021-05)Today, several specific and targeted analyses are used for detection of different chemical compounds and diagnostics of inborn errors of metabolism (IEMs). Metabolomics, an untargeted analytical approach, has been used as ... -
Klinisk betydning av automatisk varsling av blaster på hematologiinstrument
(Master thesis, 2021-05)Bakgrunn og formål Blaster er umodne blodceller som vanligvis finnes i beinmargen, men som ved ulike sykdommer og tilstander kan finnes i perifert blod, for eksempel leukemier. Ved differensialtelling av leukocytter på ... -
Undersøkelse av autofagi-nivåer i cellemodeller for dannelse og progresjon av prostatakreft
(Master thesis, 2021-05)Bakgrunn og formål Eksisterende forskning gir ingen klare svar på om autofagi opp- eller nedreguleres i cellens utvikling fra en normal celle til en aggressiv og metastaserende kreftcelle. I mangel på forskning med metoder ... -
Migration of prostate cancer cells along neurite outgrowths: optimalization of experimental conditions and characterization of nerve-cancer co-cultures
(Master thesis, 2021-05)As approximately 5000 males are diagnosed with prostate cancer every year in Norway, prostate cancer persists as a medical issue today. It is shown that tumor innervation is important for development and progression of the ... -
Establishment of a new quantitative method for in situ detection of DNA breaks in human spermatozoa
(Master thesis, 2021-05)Background: There is increasing evidence that infertile men have higher levels of DNA fragmentation compared to fertile men. It was also shown that spermatozoa with highly fragmented DNA are less motile. Several tests are ... -
Effects of the food processing contaminant acrylamide and its metabolite glycidamide in human neural stem cells undergoing differentiation
(Master thesis, 2021-05)Occupational exposure to the acrylamide (AA) monomer has been known since the 1960s to cause neurotoxicity of the central and peripheral nervous system. Concerns regarding exposure of the general populations arose upon ... -
Cytokinprofil i kolorektale tumorer - med og uten Fusobacterium nucleatum
(Master thesis, 2021)Bakgrunn og formål: Den vanlige oppfatningen er at inflammasjon i kolorektal kreft (CRC) er et resultat av den neoplastiske celleveksten. Det er vist at epitelbarrieren mot tarmlumen kan være svekket i kolorektale tumorer, ... -
Difference between volume Computed Tomography Dose Index (CTDIvol) and Size-Specific Dose Estimates (SSDE) in abdomen- and thorax protocols in patients of different sizes in different CT scanners
(Master thesis, 2021-05)Background: Volume Computed Tomography Dose Index (CTDIvol) only provides information about the radiation dose delivered by a CT scanner. The Size Specific Dose Estimate (SSDE) introduced by the American Association of ... -
Effekt av kortkjedede fettsyrer og forgreinede fettsyrer på energimetabolisme i skjelettmuskelceller
(Master thesis, 2021-05)Sammendrag Innledning: I det siste har det vært stor fokus på sammenheng mellom tarmflora og etiologien av metabolske sykdommer som fedme og type 2-diabetes. Tarmflora kan spille en viktig rolle i energimetabolisme ved ... -
Behandling av Nevroendokrine Tumorer med 177Lu-DOTATATE - Fra Pasientens Perspektiv
(Master thesis, 2021-05)I 2020 ble det på bakgrunn av en internasjonal beslutning innført peptidreseptor-nuklideterapi med 177Lu-DOTATATE ved fire norske sykehus, som et behandlingsalternativ for pasienter med nevroendokrine tumorer (NETs). For ... -
Effects of polycyclic aromatic hydrocarbons (PAHs) on cell viability and gene expression related to neurite outgrowth in human neural stem cells undergoing differentiation
(Master thesis, 2021)Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental pollutants formed under incomplete combustions of organic materials such as the burning of fossil fuels, domestic heating, automobile exhaust, cooking, ... -
Investigation of the expression profile of miRNAs regulating ADHD candidate genes.
(Master thesis, 2021)Attention-deficit/hyperactivity disorder (ADHD) is the most common child-hood onset neuropsychological disorder, characterized by symptoms such as inattention and hyperactivity/impulsivity in varying severity across ... -
Development of a liquid chromatography-tandem mass spectrometry analysis for cortisol as a stress biomarker to monitor fish welfare
(Master thesis, 2021)Background: Norway is the world’s biggest salmon producer and the salmon industry has grown to become Norway’s second largest export industry in value, after oil and gas. Despite the impressive growth, the industry is still ...
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