Browsing HV - Master i Biomedisin by Title
Now showing items 20-39 of 92
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Effect of HEMA on protein S-glutathionylation in BEAS-2B cells
(MABIOD;2017, Master thesis, 2017)Resin-based dental materials are a common first choice when restoring dental function. Both dental personnel and patients are exposed to methacrylate monomers, one main component in these materials. A concern regarding ... -
Effects of bromodomain or androgen-receptor inhibitors in combination with radiopharmaceuticals in castration-resistant prostate cancer cell monolayers and multicellular spheroids
(Master thesis, 2021)Background: Prostate cancer not responding to androgen deprivation therapy is known as castration-resistant prostate cancer (CRPC). Despite rapid increase of treatment options, the disease remains incurable, when metastases ... -
Effects of bromodomain or androgen-receptor inhibitors in combination with radiopharmaceuticals in castration-resistant prostate cancer cell monolayers and multicellular spheroids
(Master thesis, 2021-05)Background: Prostate cancer not responding to androgen deprivation therapy is known as castration-resistant prostate cancer (CRPC). Despite rapid increase of treatment options, the disease remains incurable, when metastases ... -
Effects of marine mixtures of persistent organic pollutants on steroidogenesis on LH-stimulated primary Leydig cells
(Master thesis, 2010)The ability of POPs (persistent organic pollutants) to act as endocrine disruptors and their potential role in negative trends in male reproductive health have caused increased concern over the last few decades. There ... -
Effects of polycyclic aromatic hydrocarbons (PAHs) on cell viability and gene expression related to neurite outgrowth in human neural stem cells undergoing differentiation
(Master thesis, 2021)Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental pollutants formed under incomplete combustions of organic materials such as the burning of fossil fuels, domestic heating, automobile exhaust, cooking, ... -
Effects of the food processing contaminant acrylamide and its metabolite glycidamide in human neural stem cells undergoing differentiation
(Master thesis, 2021-05)Occupational exposure to the acrylamide (AA) monomer has been known since the 1960s to cause neurotoxicity of the central and peripheral nervous system. Concerns regarding exposure of the general populations arose upon ... -
Effects of the food processing contaminant acrylamide and its metabolite glycidamide in human neural stem cells undergoing differentiation.
(Master thesis, 2021)Occupational exposure to the acrylamide (AA) monomer has been known since the 1960s to cause neurotoxicity of the central and peripheral nervous system. Concerns regarding exposure of the general populations arose upon ... -
Effekt av administrasjon av testosteron på veksthormonmarkørene insulinliknende vekstfaktor type 1 (IGF- 1) og N-terminal propeptid av type III prokollagen (PIIINP)
(MABIO;2019, Master thesis, 2019)Introduksjon: Veksthormon antas å være mye brukt av idrettsutøvere som et prestasjons-fremmende middel. Doping med veksthormon er utfordrende å detektere på grunn av 1) kort halveringstid, 2) den rekombinante formen er ... -
Effekt av kortkjedede fettsyrer og forgreinede fettsyrer på energimetabolisme i skjelettmuskelceller
(Master thesis, 2021)Innledning: I det siste har det vært stor fokus på sammenheng mellom tarmflora og etiologien av metabolske sykdommer som fedme og type 2-diabetes. Tarmflora kan spille en viktig rolle i energimetabolisme ved blant annet ... -
Effekt av kortkjedede fettsyrer og forgreinede fettsyrer på energimetabolisme i skjelettmuskelceller
(Master thesis, 2021-05)Sammendrag Innledning: I det siste har det vært stor fokus på sammenheng mellom tarmflora og etiologien av metabolske sykdommer som fedme og type 2-diabetes. Tarmflora kan spille en viktig rolle i energimetabolisme ved ... -
Effekt av β2-adrenerg reseptor på prostatakreftcellelinjer : med fokus på epitelial-mesenkymal transisjon, migrasjon & proliferasjon
(Master thesis, 2010)Prostatakreft er den vanligste kreftformen blant menn i Norge med over 4000 nye tilfeller hvert år. Økt levealder i befolkningen i tillegg til hyppigere diagnostisering i tidligere stadier av sykdommen enn tidligere, er ... -
Ekspresjon av DNA-reparasjonsprotein PARP1 i ulcerøs kolitt og kolorektalkreft: En immunhistokjemisk studie
(MABIO;2018, Master thesis, 2018)The cell's genomic integrity is essential for all life forms, and is constantly being exposed to both endogenous and exogenous threats. In order to preserve this integrity, through evolution, the cells have developed a ... -
Elucidation of the anti-tumor effect of the synthetic retinoid, CD437, in malignant melanoma
(Master thesis, 2010)The synthetic retinoid 6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthalene Carboxylic Acid (CD437/AHPN) has been shown to have an antiproliferative effect, as well as being a potent inducer of apoptosis, in many cancer ... -
Eluering av antistoff bundet til erytrocytter: Metodesammenligning og kostnads-nytte vurdering.
(MABIO;2019, Master thesis, 2019)Bakgrunn: IgG-antistoffer bundet til erytrocytter kan være involvert i ulike sykdomsprosesser som autoimmun hemolytisk anemi (AIHA), hemolytisk sykdom hos nyfødt (HSN) og serologiske transfusjonsreaksjoner. Identifisering ... -
Epigenetic and genetic influence on radiation responce.
(Master thesis, 2011)Clinical experience has demonstrated that some tumors are more resistant towards ionizing radiation than others. There is strong evidence that both genetic and epigenetic characteristics of the tumor and surrounding tissue ... -
Establishing in house workflow for detection and genotyping waterborne Escherichia coli by next generation whole genome sequencing using Ion Torrent PGM platform
(MABIOD;2017, Master thesis, 2017)Brusdalsvannet is a 7.52 km² drinking water reservoir located in Aalesund commune, surrounded by forest with high canopy cover on one side, dense habitation and the main highway into Aalesund on the other side. Consequently, ... -
Establishment and characterization of cell lines to study the proxymitome of the Centrosome and Spindle Pole-associated protein 1
(Master thesis, 2021)The predominantly expressed isoform of CSPP1, CSPP-L, is a centrosomal and Centriolar satellite protein with functions in microtubule organization in cell division and cilia formation. CSPP-L dose and microtubule organizing ... -
Establishment of a new quantitative method for in situ detection of DNA breaks in human spermatozoa
(Master thesis, 2021)Background: There is increasing evidence that infertile men have higher levels of DNA fragmentation compared to fertile men. It was also shown that spermatozoa with highly fragmented DNA are less motile. Several tests are ... -
Establishment of a new quantitative method for in situ detection of DNA breaks in human spermatozoa
(Master thesis, 2021-05)Background: There is increasing evidence that infertile men have higher levels of DNA fragmentation compared to fertile men. It was also shown that spermatozoa with highly fragmented DNA are less motile. Several tests are ... -
Establishment of PCR based methods for detection of ctDNA in blood
(Master thesis, 2013)Cell-free DNA appears in the circulation when cells undergo apoptosis and necrosis. This is a natural process and small amounts of cell-free DNA can be found in the blood of healthy individuals. When tumors are present, a ...