Slow ion concentration oscillations and multiple states in neuron–glia interaction—insights gained from reduced mathematical models
Peer reviewed, Journal article
Published version
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https://hdl.handle.net/11250/3106776Utgivelsesdato
2023Metadata
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Originalversjon
Frontiers in Network Physiology. 2023, 3 . https://doi.org/10.3389/fnetp.2023.1189118Sammendrag
When potassium in the extracellular space separating neurons and glia reaches
sufficient levels, neurons may fire spontaneous action potentials or even become
inactivated due to membrane depolarisation, which, in turn, may lead to increased
extracellular potassium levels. Under certain circumstances, this chain of events
may trigger periodic bursts of neuronal activity. In the present study, reduced
neuron–glia models are applied to explore the relationship between bursting
behaviour and ion concentration dynamics. These reduced models are built based
on a previously developed neuron–glia model, in which channel-mediated
neuronal sodium and potassium currents are replaced by a function of
neuronal sodium and extracellular potassium concentrations. Simulated
dynamics of the resulting two reduced models display features that are
qualitatively similar to those of the existing neuron–glia model. Bifurcation
analyses of the reduced models show rich and interesting dynamics that
include the existence of Hopf bifurcations between which the models exhibit
slow ion concentration oscillations for a wide range of parameter values. The
study demonstrates that even very simple models can provide insights of possible
relevance to complex phenomena.