Blar i HV - Master i Biomedisin på utgivelsesdato
Viser treff 61-80 av 92
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HPV chromosomal integration as a biomarker for cancer progression
(Master thesis, 2021)Background: Human papillomavirus (HPV) is associated with 4,5% of all human cancers worldwide including cervical cancer. Cytological and/or HPV primary screening is used to uncover cancer precursors. Still, better clinical ... -
Exploring changes in long non-coding RNAs during neonatal hypoxia-ischemia using a piglet model
(Master thesis, 2021)Background: Despite major advances in research and clinical care during the last decade, hypoxic-ischemic encephalopathy (HIE) remains one of the leading causes worldwide of death and disability in children under five years ... -
Effekt av kortkjedede fettsyrer og forgreinede fettsyrer på energimetabolisme i skjelettmuskelceller
(Master thesis, 2021)Innledning: I det siste har det vært stor fokus på sammenheng mellom tarmflora og etiologien av metabolske sykdommer som fedme og type 2-diabetes. Tarmflora kan spille en viktig rolle i energimetabolisme ved blant annet ... -
Establishment of a new quantitative method for in situ detection of DNA breaks in human spermatozoa
(Master thesis, 2021)Background: There is increasing evidence that infertile men have higher levels of DNA fragmentation compared to fertile men. It was also shown that spermatozoa with highly fragmented DNA are less motile. Several tests are ... -
Migration of prostate cancer cells along neurite outgrowths: optimalization of experimental conditions and characterization of nerve-cancer co-cultures
(Master thesis, 2021)As approximately 5000 males are diagnosed with prostate cancer every year in Norway, prostate cancer persists as a medical issue today. It is shown that tumor innervation is important for development and progression of the ... -
Synthesis and LC-MS Analysis of Cinchona Derivatives
(Master thesis, 2021)Cinchona alkaloids with their main component Quinine, are isolated from the barks of several species of cinchona trees and have been used in medicine for over 400 years mainly as anti-malarial medication. These natural ... -
Optimizing DNA Extraction from Dried Blood Spots for Biological Age Measurements
(Master thesis, 2021)While the chronological age is the time that has passed since birth, the biological age is determined by physiological signs of aging. Methylation at CpG sites has proven to be a promising biomarker of biological age, and ... -
Development of a liquid chromatography-tandem mass spectrometry analysis for cortisol as a stress biomarker to monitor fish welfare
(Master thesis, 2021)Background: Norway is the world’s biggest salmon producer and the salmon industry has grown to become Norway’s second largest export industry in value, after oil and gas. Despite the impressive growth, the industry is still ... -
Establishment and characterization of cell lines to study the proxymitome of the Centrosome and Spindle Pole-associated protein 1
(Master thesis, 2021)The predominantly expressed isoform of CSPP1, CSPP-L, is a centrosomal and Centriolar satellite protein with functions in microtubule organization in cell division and cilia formation. CSPP-L dose and microtubule organizing ... -
Investigation of the expression profile of miRNAs regulating ADHD candidate genes.
(Master thesis, 2021)Attention-deficit/hyperactivity disorder (ADHD) is the most common child-hood onset neuropsychological disorder, characterized by symptoms such as inattention and hyperactivity/impulsivity in varying severity across ... -
Effects of polycyclic aromatic hydrocarbons (PAHs) on cell viability and gene expression related to neurite outgrowth in human neural stem cells undergoing differentiation
(Master thesis, 2021)Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental pollutants formed under incomplete combustions of organic materials such as the burning of fossil fuels, domestic heating, automobile exhaust, cooking, ... -
Cytokinprofil i kolorektale tumorer - med og uten Fusobacterium nucleatum
(Master thesis, 2021)Bakgrunn og formål: Den vanlige oppfatningen er at inflammasjon i kolorektal kreft (CRC) er et resultat av den neoplastiske celleveksten. Det er vist at epitelbarrieren mot tarmlumen kan være svekket i kolorektale tumorer, ... -
Deep inspiration breath-hold in stereotactic and conventional fractionated radiotherapy of lesions in the lung
(Master thesis, 2021)The purpose of the clinical study was to evaluate lung cancer patients’ ability to perform deep inspiration breath-hold (DIBH) during CT simulation and throughout the treatment course of radiation therapy (RT). In addition, ... -
Identification and characterization of human branched-chain amino acid transaminase 1 inhibitors
(Master thesis, 2021)Branched-chain amino acid transaminase 1 (BCAT1) is a protein known to be upregulated in severe cancers such as brain-, pancreatic-, and breast cancer, as well as in the neurodegenerative Alzheimer’s disease. Via structural-, ... -
Synthesis and LC-MS Analysis of Cinchona Derivatives
(Master thesis, 2021)Cinchona alkaloids with their main component Quinine, are isolated from the barks of several species of cinchona trees and have been used in medicine for over 400 years mainly as anti-malarial medication. These natural ... -
Difference between volume Computed Tomography Dose Index (CTDIvol) and Size-Specific Dose Estimates (SSDE) in abdomen- and thorax protocols in patients of different sizes in different CT scanners
(Master thesis, 2021-05)Background: Volume Computed Tomography Dose Index (CTDIvol) only provides information about the radiation dose delivered by a CT scanner. The Size Specific Dose Estimate (SSDE) introduced by the American Association of ... -
Effects of bromodomain or androgen-receptor inhibitors in combination with radiopharmaceuticals in castration-resistant prostate cancer cell monolayers and multicellular spheroids
(Master thesis, 2021-05)Background: Prostate cancer not responding to androgen deprivation therapy is known as castration-resistant prostate cancer (CRPC). Despite rapid increase of treatment options, the disease remains incurable, when metastases ... -
Undersøkelse av autofagi-nivåer i cellemodeller for dannelse og progresjon av prostatakreft
(Master thesis, 2021-05)Bakgrunn og formål Eksisterende forskning gir ingen klare svar på om autofagi opp- eller nedreguleres i cellens utvikling fra en normal celle til en aggressiv og metastaserende kreftcelle. I mangel på forskning med metoder ... -
Migration of prostate cancer cells along neurite outgrowths: optimalization of experimental conditions and characterization of nerve-cancer co-cultures
(Master thesis, 2021-05)As approximately 5000 males are diagnosed with prostate cancer every year in Norway, prostate cancer persists as a medical issue today. It is shown that tumor innervation is important for development and progression of the ... -
Effekt av kortkjedede fettsyrer og forgreinede fettsyrer på energimetabolisme i skjelettmuskelceller
(Master thesis, 2021-05)Sammendrag Innledning: I det siste har det vært stor fokus på sammenheng mellom tarmflora og etiologien av metabolske sykdommer som fedme og type 2-diabetes. Tarmflora kan spille en viktig rolle i energimetabolisme ved ...