dc.contributor.author | Lysvik, Elisabeth Kirkeby | |
dc.contributor.author | Mikalsen, Lars Tore Gyland | |
dc.contributor.author | Rootwelt-Revheim, Mona Elisabeth | |
dc.contributor.author | Emblem, Kyrre Eeg | |
dc.contributor.author | Hjørnevik, Trine | |
dc.date.accessioned | 2024-02-21T12:42:14Z | |
dc.date.available | 2024-02-21T12:42:14Z | |
dc.date.created | 2023-11-02T11:22:41Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | EJNMMI Physics. 2023, 10 (1), 1-13. | en_US |
dc.identifier.issn | 2197-7364 | |
dc.identifier.uri | https://hdl.handle.net/11250/3119040 | |
dc.description.abstract | Background: Q.Clear, a Bayesian penalized likelihood reconstruction algorithm, has shown high potential in improving quantitation accuracy in PET systems. The Q.Clear algorithm controls noise during the iterative reconstruction through a β penalization factor. This study aimed to determine the optimal β-factor for accurate quantitation of dynamic PET scans. Methods: A Flangeless Esser PET Phantom with eight hollow spheres (4-25 mm) was scanned on a GE Discovery MI PET/CT system. Data were reconstructed into five sets of variable acquisition times using Q.Clear with 18 different β-factors ranging from 100 to 3500. The recovery coefficient (RC), coefficient of variation (CVRC) and root-mean-square error (RMSERC) were evaluated for the phantom data. Two male patients with recurrent glioblastoma were scanned on the same scanner using 18F-PSMA-1007. Using an irreversible two-tissue compartment model, the area under curve (AUC) and the net influx rate Ki were calculated to assess the impact of different β-factors on the pharmacokinetic analysis of clinical PET brain data. Results: In general, RC and CVRC decreased with increasing β-factor in the phantom data. For small spheres ( | en_US |
dc.language.iso | eng | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Optimization of Q.Clear reconstruction for dynamic 18F PET imaging | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.doi | 10.1186/s40658-023-00584-1 | |
dc.identifier.cristin | 2191404 | |
dc.source.journal | EJNMMI Physics | en_US |
dc.source.volume | 10 | en_US |
dc.source.issue | 1 | en_US |
dc.source.pagenumber | 1-13 | en_US |
dc.relation.project | Norges forskningsråd: 303249 | en_US |