Recent Submissions

  • Change in Ocular Surface Staining during Eyelid Warming Is Related to Tear Cytokine Levels 

    Landsend, Erlend Christoffer Sommer; Olafsson, Jonatan; Lai, Xiaoran; Aass, Hans Christian Dalsbotten; Utheim, Tor Paaske (Journal of ophthalmology;Volume 2022, Article ID 5103231, Peer reviewed; Journal article, 2022-08-03)
    Purpose. To investigate the changes in the tear cytokine profile of patients with meibomian gland dysfunction (MGD) treated with eyelid warming and to correlate these changes with clinical parameters for dry eye disease ...
  • The effect of toll-like receptor ligands on energy metabolism and myokine expression and secretion in cultured human skeletal muscle cells 

    Tingstad, Ragna Husby; Norheim, Frode Amador; Haugen, Fred; Feng, Yuan Zeng; Tunsjø, Hege; Thoresen, G. Hege; Rustan, Arild Christian; Charnock, Colin; Aas, Vigdis (Scientific Reports;11, Article number: 24219 (2021), Peer reviewed; Journal article, 2021-12-20)
    Skeletal muscle plays an important role in glycaemic control and metabolic homeostasis, making it a tissue of interest with respect to type 2 diabetes mellitus. The aim of the present study was to determine if ligands of ...
  • In-office thermal systems for the treatment of dry eye disease 

    Beining, Marie Wangen; Magnø, Morten Scherven; Moschowits, Emily; Olafsson, Jonatan; Vehof, Jelle; Dartt, Darlene Ann; Utheim, Tor Paaske (Survey of ophthalmology;Volume 67, Issue 5, September–October 2022, Peer reviewed; Journal article, 2022-08-12)
    Dry eye disease affects millions of people worldwide, causing pain, vision disturbance, and reduced productivity. Meibomian gland dysfunction, a major cause of dry eye, is characterized by chronic glandular inflammation, ...
  • Short- and long-term effects of body weight, calorie restriction and gastric bypass on CYP1A2, CYP2C19 and CYP2C9 activity 

    Kvitne, Kine Eide; Krogstad, Veronica; Wegler, Christine; Johnson, Line Kristin; Kringen, Marianne K.; Hovd, Markus Herberg; Hertel, Jens Kristoffer; Heijer, Maria; Sandbu, Rune; Skovlund, Eva; Artursson, Per; Karlsson, Cecilia; Andersson, Shalini; Andersson, Tommy B.; Hjelmesæth, Jøran Sture; Åsberg, Anders; Jansson-Löfmark, Rasmus; Christensen, Hege; Robertsen, Ida (British Journal of Clinical Pharmacology;Volume 88, Issue 9, Peer reviewed; Journal article, 2022-04-11)
    Aim: Roux-en-Y gastric bypass (RYGB) may influence drug disposition due to surgery-induced gastrointestinal alterations and/or subsequent weight loss. The objective was to compare short- and long-term effects of RYGB and ...
  • Definitions and measurement of health literacy in health and medicine research: A systematic review 

    Urstad, Kristin Hjorthaug; Andersen, Marit Helen; Larsen, Marie Hamilton; Borge, Christine Råheim; Helseth, Sølvi; Wahl, Astrid Klopstad (BMJ Open;Volume 12, Issue 2, Peer reviewed; Journal article, 2022)
    Objectives: The way health literacy is understood (conceptualised) should be closely linked to how it is measured (operationalised). This study aimed to gain insights into how health literacy is defined and measured in ...
  • Solid lipid nanoparticle-loaded mucoadhesive buccal films: Critical quality attributes and in vitro safety & efficacy 

    Tzanova, Martina; Hagesæther, Ellen; Tho, Ingunn (Peer reviewed; Journal article, 2020)
    The objective of this work was to develop and characterize solid lipid nanoparticle (SLN)-loaded mucoadhesive films to reveal their potential as successful drug formulations. SLNs based on lipid (Lipoid S100) and surfactant ...
  • The Evaluation of a Social Media Campaign to Increase COVID-19 Testing in Migrant Groups: Cluster Randomized Trial 

    Elgersma, Ingeborg Hess; Fretheim, Atle; Indseth, Thor; Munch, Anita Thorolvsen; Johannessen, Live Bøe; Hansen, Christine Engh (Journal of Medical Internet Research;Vol 24, No 3 (2022): March, Peer reviewed; Journal article, 2022-03-24)
    Background: A low test positivity rate is key to keeping the COVID-19 pandemic under control. Throughout the pandemic, several migrant groups in Norway have seen higher rates of confirmed COVID-19 and related hospitalizations, ...
  • The therapeutic benefits of nanoencapsulation in drug delivery to the anterior segment of the eye: A systematic review 

    Bandhari, Madhavi; Nguyen, Sanko; Yazdani, Mazyar; Utheim, Tor Paaske; Hagesæther, Ellen (Frontiers in Pharmacology;May 2022 | Volume 13 | Article 903519, Peer reviewed; Journal article, 2022-05-13)
    Background: Although numerous nanoparticle formulations have been developed for ocular administration, concerns are being raised about a possible mismatch between potential promises made by the field of nanoparticle research ...
  • Lessons from working across fields to develop a framework for informed choices 

    Stewart, Ruth; Aronson, Jeffrey K.; Barends, Eric; Boruch, Robert; Brennan, Marnie; Chislett, Joe; Cunliffe-Jones, Peter; Maynard, Brandy; Oxman, Matt; Pullin, Andrew; Randall, Nicola; Sharples, Jonathan; Stott, Janet; Vale, Luke (Research for All;Volume: 6, Issue: 1, Peer reviewed; Journal article, 2022-02-08)
    In late 2018, Iain Chalmers, Andy Oxman and others from the Informed Health Choices team convened a cross-field forum to develop a generic framework of key concepts for thinking critically about claims, research and choices ...
  • Expression Analysis in Atlantic Salmon Liver Reveals miRNAs Associated with Smoltification and Seawater Adaptation 

    Shwe, Alice; Krasnov, Aleksei; Visnovska, Martina; Ramberg, Sigmund; Tone-Kari, Østbye; Andreassen, Rune (Biology (Basel);Volume 11 / Issue 5, Peer reviewed; Journal article, 2022-04-30)
    Smoltification is a developmental process that preadapts Atlantic salmon for a life in seawater. Suboptimal smoltification and poor timing of transfer to seawater is associated with increased mortality. MicroRNAs (miRNAs) ...
  • Short-Term Functional and Morphological Changes in Primary Cultures of Trigeminal Ganglion Cells 

    Pires Veríssimo, Carla; Filha, Lionete Gall Acosta; da Silva, Fábio Jorge Moreira; Westgarth, Harrison; Aguia, Juliana De Mattos Coelho; Pontes, Bruno; Moura-Neto, Vivaldo; Gazerani, Parisa; DosSantos, Marcos Fabio (Current Issues in Molecular Biology;Volume 44 / Issue 3, Peer reviewed; Journal article, 2022-03-08)
    Several studies have proved that glial cells, as well as neurons, play a role in pain patho-physiology. Most of these studies have focused on the contribution of central glial cells (e.g., microglia and astrocytes) to ...
  • Detection and significance of small and low proliferation breast cancer 

    Hofvind, Solveig; Knutsvik, Gøril; Holen, Åsne Sørlien; Tsuruda, Kaitlyn; Akslen, Lars Andreas (Journal of Medical Screening;Volume: 29, issue: 1, Peer reviewed; Journal article, 2021-06-22)
    Objectives: To determine the frequency and discuss possible implications of early breast cancer with particularly good prognosis and defined by tumor diameter and cell proliferation. Setting: Detection of small and ...
  • Prognostic Value of Nucleated RBCs for Patients With Suspected Sepsis in the Emergency Department: A Single-Center Prospective Cohort Study 

    Amundsen, Erik Koldberg; Binde, Christina; Christensen, Erik Egeland; Klingenberg, Olav Inge; Kvale, Dag; Holten, Aleksander Rygh (Critical Care Explorations;, Peer reviewed; Journal article, 2021-07)
    Objectives: Increase of nucleated RBCs in peripheral blood has been shown to be predictive of mortality in ICU patients. The aim of this study was to explore the prognostic value of nucleated RBCs in the first blood sample ...
  • Frailty assessment of older adults, first-time applicants of public home care service in Norway 

    Laukli, Ingerid; Sandvik, Leiv; Ormstad, Heidi (Scandinavian Journal of Primary Health Care;Volume 39, 2021 - Issue 1, Peer reviewed; Journal article, 2021-02-08)
    Objective: Early detection of frailty is essential to prevent or delay disability. The most appropriate screening tool for frailty among home-dwelling older adults is under debate. The present study estimates the prevalence ...
  • Changes in the use of antiseizure medications in children and adolescents in Norway, 2009–2018 

    Heger, Katrine; Skipsfjord, Julia; Kiselev, Yury; Burns, Margrete Larsen; Aaberg, Kari Modalsli; Johannessen, Svein Ivar; Skurtveit, Svetlana Ondrasova; Landmark, Cecilie Johannessen (Epilepsy Research;Volume 181, March 2022, 106872, Peer reviewed; Journal article, 2022-02-15)
    Background: The use of antiseizure medications (ASMs) in the pediatric population is poorly studied. The purpose of this study was to investigate changes in the use of ASMs in children and adolescents compared to adults, ...
  • Hemoglobinopathy gone astray—three novel forms of α-thalassemia in Norwegian patients characterized by quantitative real-time PCR and DNA sequencing 

    Grimholt, Runa Marie; Fjeld, Bente; Klingenberg, Olav (Scandinavian Journal of Clinical and Laboratory Investigation;Volume 81, 2021 - Issue 8, Peer reviewed; Journal article, 2021-11-18)
    α-thalassemia is one of the most common monogenic diseases worldwide and is caused by reduced or absent synthesis of α-globin chains, most commonly due to deletions of one or more of the α-globin genes. α-thalassemia occurs ...
  • Prosigna Gene Signature to Assess Expected Benefit from Chemotherapy in Breast Cancer. Assessment of manufacturer’s submission 

    Kvist, Beate Charlotte Fagerlund; Chudasama, Kishan Kumar; Brurberg, Kjetil Gundro; Robberstad, Bjarne; Rose, Christopher James; Juvet, Lene Kristine; Fretheim, Atle (Book; Peer reviewed; Research report, 2019-08-16)
    Breast cancer can be treated with chemotherapy, hormone therapy and radiation, or a combination of these to prevent the spread of cancer cells, after surgical removal of the tumor. When assessing whether a patient should ...
  • Medication dose calculation errors and other numeracy mishaps in hospitals: Analysis of the nature and enablers of incident reports 

    Mulac, Alma; Hagesæther, Ellen; Granås, Anne Gerd (Journal of Advanced Nursing;Volume 78, Issue 1, Peer reviewed; Journal article, 2021-10-10)
    Aims: To investigate medication dose calculation errors and other numeracy mishaps in hospitals and examine mechanisms and enablers which lead to such errors. Design: A retrospective study using descriptive statistics ...
  • The Bridge Building Model: connecting evidence-based practice, evidence-based research, public involvement and needs led research 

    Ormstad, Heidi; Jamtvedt, Gro; Svege, Ida; Crowe, Sally (Research Involvement and Engagement;7, Article number: 77 (2021), Peer reviewed; Journal article, 2021-10-30)
    This paper describes a model that combines different concepts in healthcare research that the authors suggest belong together. The concepts are; Evidence Based Practice, where healthcare is based on the best research ...
  • Artificial intelligence in the fertility clinic: status, pitfalls and possibilities 

    Riegler, Michael Alexander; Stensen, Mette Haug; Witczak, Oliwia; Andersen, Jorunn Marie; Hicks, Steven; Hammer, Hugo Lewi; Delbarre, Erwan; Halvorsen, Pål; Yazidi, Anis; Holst, Nicolai; Haugen, Trine B. (Human Reproduction;Volume 36, Issue 9, Peer reviewed; Journal article, 2021-07-29)
    In recent years, the amount of data produced in the field of assisted reproduction technology [ART] has increased exponentially. The diversity of data is large, ranging from videos to tabular data. At the same time, ...

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