dc.contributor.author | Eide, Per Kristian | |
dc.contributor.author | Lashkarivand, Aslan | |
dc.contributor.author | Pripp, Are Hugo | |
dc.contributor.author | Valnes, Lars Magnus | |
dc.contributor.author | Hovd, Markus Herberg | |
dc.contributor.author | Ringstad, Geir | |
dc.contributor.author | Blennow, Kaj | |
dc.contributor.author | Zetterberg, Henrik | |
dc.date.accessioned | 2024-01-10T10:19:28Z | |
dc.date.available | 2024-01-10T10:19:28Z | |
dc.date.created | 2023-06-27T14:32:44Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Nature Communications. 2023, 14 1-14. | en_US |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | https://hdl.handle.net/11250/3110820 | |
dc.description.abstract | Clearance of neurotoxic brain proteins via cerebrospinal fluid (CSF) to blood
has recently emerged to be crucial, and plasma biomarkers of neurodegen-
eration were newly introduced to predict neurological disease. This study
examines in 106 individuals with neurological disorders associations between
plasma biomarkers [40 and 42 amino acid-long amyloid-β (Aβ40 and Aβ42),
total-tau, glial fibrillary acidic protein (GFAP), and neurofilament light (NfL)]
and magnetic resonance imaging measures of CSF-mediated clearance from
brain via extra-vascular pathways (proxy of glymphatic function) and CSF-to-
blood clearance variables from pharmacokinetic modeling (proxy of menin-
geal lymphatic egress). We also examine how biomarkers vary during daytime
and associate with subjective sleep quality. Plasma concentrations of neuro-
degeneration markers associate with indices of glymphatic and meningeal
lymphatic functions in individual- and disease-specific manners, vary during
daytime, but are unaffected by sleep quality. The results suggest that plasma
concentrations of neurodegeneration biomarkers associate with measures of
glymphatic and meningeal lymphatic function. | en_US |
dc.language.iso | eng | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Plasma neurodegeneration biomarker concentrations associate with glymphatic and meningeal lymphatic measures in neurological disorders | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.doi | 10.1038/s41467-023-37685-5 | |
dc.identifier.cristin | 2158758 | |
dc.source.journal | Nature Communications | en_US |
dc.source.volume | 14 | en_US |
dc.source.pagenumber | 1-14 | en_US |