Global, regional, and national incidence of six major immune-mediated inflammatory diseases: Findings from the global burden of disease study 2019
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Date
2023Metadata
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10.1016/j.eclinm.2023.102193Abstract
Background The causes for immune-mediated inflammatory diseases (IMIDs) are diverse and the incidence trends of
IMIDs from specific causes are rarely studied. The study aims to investigate the pattern and trend of IMIDs from
1990 to 2019.
Methods We collected detailed information on six major causes of IMIDs, including asthma, inflammatory bowel
disease, multiple sclerosis, rheumatoid arthritis, psoriasis, and atopic dermatitis, between 1990 and 2019, derived
from the Global Burden of Disease study in 2019. The average annual percent change (AAPC) in number of incidents
and age standardized incidence rate (ASR) on IMIDs, by sex, age, region, and causes, were calculated to quantify the
temporal trends.
Findings In 2019, rheumatoid arthritis, atopic dermatitis, asthma, multiple sclerosis, psoriasis, inflammatory bowel
disease accounted 1.59%, 36.17%, 54.71%, 0.09%, 6.84%, 0.60% of overall new IMIDs cases, respectively. The ASR of
IMIDs showed substantial regional and global variation with the highest in High SDI region, High-income North
America, and United States of America. Throughout human lifespan, the age distribution of incident cases from
six IMIDs was quite different. Globally, incident cases of IMIDs increased with an AAPC of 0.68 and the ASR
decreased with an AAPC of −0.34 from 1990 to 2019. The incident cases increased across six IMIDs, the ASR of
rheumatoid arthritis increased (0.21, 95% CI 0.18, 0.25), while the ASR of asthma (AAPC = −0.41), inflammatory
bowel disease (AAPC = −0.72), multiple sclerosis (AAPC = −0.26), psoriasis (AAPC = −0.77), and atopic dermatitis
(AAPC = −0.15) decreased. The ASR of overall and six individual IMID increased with SDI at regional and global
level. Countries with higher ASR in 1990 experienced a more rapid decrease in ASR.
Interpretation The incidence patterns of IMIDs varied considerably across the world. Innovative prevention and
integrative management strategy are urgently needed to mitigate the increasing ASR of rheumatoid arthritis and
upsurging new cases of other five IMIDs, respectively.