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dc.contributor.authorDosSantos, Marcos Fabio
dc.contributor.authorFilha, Lionete Gall Acosta
dc.contributor.authorVeríssimo, Carla P
dc.contributor.authorSanz, Carolina K
dc.contributor.authorGazerani, Parisa
dc.date.accessioned2023-05-10T07:18:43Z
dc.date.available2023-05-10T07:18:43Z
dc.date.created2023-05-09T12:32:02Z
dc.date.issued2023
dc.identifier.issn0219-6352
dc.identifier.issn1757-448X
dc.identifier.urihttps://hdl.handle.net/11250/3067399
dc.description.abstractPotassium (K+) channels establish and maintain the resting potential of most living cells. Their activity is predominantly regulated by the membrane voltage or the K+ gradient across the cell membrane. However, many cells also express small-conductance calcium-activated potassium (SK) channels, which have the unique ability to translate changes in the level of the intracellular second messenger, Ca2+ to changes in the membrane K+ conductance and, therefore, the resting membrane potential. This article reviews the structure, presence, distribution, and function of SK channels, their pharmacological modulation, and their role in health and disease, emphasizing nociception and pain.en_US
dc.language.isoengen_US
dc.publisherIMR Pressen_US
dc.relation.ispartofseriesJournal of Integrative Neuroscience (JIN);
dc.relation.urihttps://www.imrpress.com/journal/JIN/22/3/10.31083/j.jin2203069/htm
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titlePresence of Small-Conductance Calcium-Activated Potassium (SK) Channels in the Central and Peripheral Nervous Systems and Their Role in Health and Diseaseen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doihttps://doi.org/10.31083/j.jin2203069
dc.identifier.cristin2146404
dc.source.journalJournal of Integrative Neuroscience (JIN)en_US
dc.source.volume22en_US
dc.source.issue3en_US


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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal