• norsk
    • English
  • English 
    • norsk
    • English
  • Login
View Item 
  •   Home
  • Sentraladministrasjonen
  • Publikasjoner fra Cristin
  • View Item
  •   Home
  • Sentraladministrasjonen
  • Publikasjoner fra Cristin
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Patterns of aggressiveness: Risk of progression to invasive breast cancer by mammographic features of calcifications in screen-detected ductal carcinoma in situ

Lilleborge, Marie; Falk, Ragnhild Sørum; Hovda, Tone; Holmen, Marit Muri; Ursin, Giske; Hofvind, Solveig
Peer reviewed, Journal article
Accepted version
Thumbnail
View/Open
postprint-patterns of aggressiveness-acta radiologica-2021.pdf (318.2Kb)
URI
https://hdl.handle.net/11250/2981624
Date
2021
Metadata
Show full item record
Collections
  • HV - Institutt for naturvitenskapelige helsefag [449]
  • Publikasjoner fra Cristin [4160]
Original version
Acta Radiologica. 2021, 1-10.   10.1177/02841851211006319
Abstract
Background

Mammographic features of calcifications on mammograms showing invasive breast cancer are associated with survival. Less is known about mammographic features and progression to invasive breast cancer among women treated for ductal carcinoma in situ (DCIS).

Purpose

To investigate mammographic features of calcifications in screen-detected DCIS in women who later did and did not get diagnosed with invasive breast cancer.

Material and Methods

This registry-based nested case-control study analyzed data from women with screen-detected DCIS in BreastScreen Norway, 1995–2016. Within this cohort of women with DCIS, those who were later diagnosed with invasive breast cancer (cases) were matched (1:2) to women who were not diagnosed with invasive breast cancer (controls) after their DCIS and by the end of 2016. Information on mammographic features were collected by a national radiological review, where screening mammograms were reviewed locally at each of the 16 breast centers in Norway. We used conditional logistic regression analysis to estimate associations between mammographic features of calcifications in the DCIS mammogram and the risk of subsequent invasive breast cancer.

Results

We found a higher risk of invasive breast cancer associated with fine linear branching (casting) morphology (odds ratio 20.0; 95% confidence interval [CI] 2.5–158.9) compared to fine linear or fine pleomorphic morphology. Regional or diffuse distribution showed an odds ratio of 2.8 (95% CI 1.0–8.2) compared to segmental or linear distribution.

Conclusion

Mammographic features of calcifications in screen-detected DCIS were of influence on the risk of invasive breast cancer. Unfavorable characteristics of DCIS were fine linear branching morphology, and regional or diffuse distribution.
Publisher
SAGE Publications
Journal
Acta Radiologica

Contact Us | Send Feedback

Privacy policy
DSpace software copyright © 2002-2019  DuraSpace

Service from  Unit
 

 

Browse

ArchiveCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsDocument TypesJournalsThis CollectionBy Issue DateAuthorsTitlesSubjectsDocument TypesJournals

My Account

Login

Statistics

View Usage Statistics

Contact Us | Send Feedback

Privacy policy
DSpace software copyright © 2002-2019  DuraSpace

Service from  Unit