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dc.contributor.authorDunker, Øystein
dc.contributor.authorLie, Marie
dc.contributor.authorNilsen, Kristian Bernhard
dc.date.accessioned2022-01-20T15:52:45Z
dc.date.available2022-01-20T15:52:45Z
dc.date.created2021-06-02T14:12:26Z
dc.date.issued2021-02-04
dc.identifier.citationClinical Neurophysiology Practice. 2021, 6 63-71.en_US
dc.identifier.issn2467-981X
dc.identifier.urihttps://hdl.handle.net/11250/2838554
dc.description.abstractObjective: Quantitative thermal testing (QTT) is a psychophysical assessment method of small nerve fibers that relies on reference material to assess function. Normal limits for within-subject comparisons of thermal thresholds are scarce, and their association with age, height and sex is not fully elucidated. The aim of this study was to investigate the normal limits for distal-proximal– and contralateral homologous comparisons of thermal thresholds with QTT, and their association with age, sex or height. Methods: Fifty healthy volunteers ages 20–79 participated in the experiment. Cold detection thresholds (CDT), warm detection thresholds (WDT), heat pain thresholds (HPT), and cold pain thresholds (CPT) were measured bilaterally at the thenar eminence, anterior thigh, distal medial leg and foot dorsum. Sample normal limits were calculated as (mean) ± 2 SD. Results: Forty-eight subjects were included in the analysis. CPT was excluded from all analyses due to a large floor-effect. Sample normal limits for side-differences ranged from 1.8 to 7.2 °C for CDT, 2.4–6.8 °C for WDT and 3.2–4.0 °C for HPT, depending on anatomical site. For distal-proximal comparisons, sample normal limits ranged from 4.0 to 8.7 °C for CDT, 6.0–14.0 °C for WDT and 4.2–9.0 °C for HPT, depending on the pairs compared. Age was associated with side-differences for CDT in the thenar eminences (p < 0.001) and distal medial legs (p < 0.002), and with 11 of 18 distal-proximal comparisons (p < 0.01). Conclusions: The normal limits for distal-proximal- and contralateral homologous thermal thresholds were wide, and thus of limited use in a clinical setting, although the reported values may be somewhat inflated by low sample-size and consequent age-pooling. Age, but not sex or height, was associated with contralateral differences in CDT in the thenar eminences and distal medial legs, and with most distal-proximal differences. Significance: Due to wide normal limits, we advise caution when utilizing relative comparisons of thermal thresholds for diagnostic purposes.en_US
dc.description.sponsorshipFunding was received from Oslo University Hospital and Oslo Metropolitan University.en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.ispartofseriesClinical Neurophysiology Practice;Volume 6
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.subjectQuantitative thermal testingen_US
dc.subjectThermal thresholdsen_US
dc.subjectThermal testingen_US
dc.subjectThermal perceptionsen_US
dc.subjectNormative dataen_US
dc.subjectReference valuesen_US
dc.titleCan within-subject comparisons of thermal thresholds be used for diagnostic purposes?en_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.rights.holder© 2021 International Federation of Clinical Neurophysiology.en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doihttps://doi.org/10.1016/j.cnp.2021.01.002
dc.identifier.cristin1913305
dc.source.journalClinical Neurophysiology Practiceen_US
dc.source.volume6en_US
dc.source.pagenumber63-71en_US


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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal