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dc.contributor.authorRognli, Eline B.
dc.contributor.authorBramness, Jørgen Gustav
dc.contributor.authorvon Soest, Tilmann
dc.identifier.citationPsychological Medicine. 2021, 1-10.en_US
dc.description.abstractBackground. Whether smoking should be regarded as a risk factor for mental disorders remains unresolved. Prescribed psychotropic drugs can be used as indications for mental disorders. We investigated how smoking was prospectively related to prescription of antipsychotics, mood stabilizers, antidepressants, and anxiolytics. Methods. Information about smoking, including the Fagerström Test for Nicotine Dependence, and relevant confounders, were obtained from the population-based Young in Norway Study (N = 2602), with four data collection waves between 1992 and 2006. These survey data were linked with information on prescriptions for psychotropic drugs from the comprehensive, nationwide Norwegian Prescription Database from 2007 to 2015. Results. Daily smoking with high dependence in 2006 at age 28.5 (S.D. = 2.0) was associated with filling prescriptions of antipsychotics (OR, 6.57, 95% CI 2.19–19.70, p = 0.001), mood stabilizers (OR, 7.11, 95% CI 2.51–20.15, p < 0.001) and antidepressants (OR, 1.91, 95% CI 1.13–3.23, p = 0.016) 1–9 years later. Associations remained significant after adjustment for a variety of potential confounders measured before the assessment of smoking, including sociodemographic background, conduct problems, cannabis use, mental distress, and previous prescriptions for psychotropic medications. The association between smoking and prescription of anxiolytics was weaker and more unstable. Conclusions. In this study of young adults, daily smoking with high dependence was associated with later prescriptions of antipsychotics, mood stabilizers and antidepressants, indicating smoking as a risk factor for mental disorders treated with these drugs. Introductionen_US
dc.description.sponsorshipThis work was supported by two grants from the Research Council of Norway (TvS, grant numbers 288083 and 301010).en_US
dc.publisherCambridge University Pressen_US
dc.relation.ispartofseriesPsychological Medicine;
dc.rightsNavngivelse 4.0 Internasjonal*
dc.subjectBipolar disordersen_US
dc.subjectCigarette smokingen_US
dc.subjectDrug prescriptionsen_US
dc.subjectMental disordersen_US
dc.subjectNicotine dependenceen_US
dc.subjectPsychotic disordersen_US
dc.titleSmoking in early adulthood is prospectively associated with prescriptions of antipsychotics, mood stabilizers, antidepressantsand anxiolyticsen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.rights.holder© The Author(s) 2021.en_US
dc.source.journalPsychological Medicineen_US
dc.relation.projectNorges forskningsråd: 301010en_US
dc.relation.projectNorges forskningsråd: 288083en_US

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