Blar i HV - Institutt for naturvitenskapelige helsefag på tidsskrift "Scientific Reports"
Viser treff 1-9 av 9
-
The effect of toll-like receptor ligands on energy metabolism and myokine expression and secretion in cultured human skeletal muscle cells
(Scientific Reports;11, Article number: 24219 (2021), Peer reviewed; Journal article, 2021-12-20)Skeletal muscle plays an important role in glycaemic control and metabolic homeostasis, making it a tissue of interest with respect to type 2 diabetes mellitus. The aim of the present study was to determine if ligands of ... -
Knockdown of SPRY4 and SPRY4-IT1 inhibits cell growth and phosphorylation of Akt in human testicular germ cell tumours
(Scientific Reports;Volume 8, Article number: 2462 (2018), Journal article; Peer reviewed, 2018-02-06)Testicular germ cell tumour (TGCT) is the most common cancer in young men in large parts of the world, but the aetiology is mainly unknown. Genome-wide association studies have so far identified about 50 susceptibility ... -
Patients with non-Sjögren's sicca report poorer general and oral health-related quality of life than patients with Sjögren's syndrome: a cross-sectional study
(Scientific Reports;10, Article number: 2063 (2020), Journal article; Peer reviewed, 2020-02-07)Understanding the impact of the disease on quality of life is crucial in patient management. In this cross-sectional study, general and oral health-related quality of life questionnaires, and thorough examinations of oral ... -
A preliminary study of the use of MinION sequencing to specifcally detect Shiga toxin‑producing Escherichia coli in culture swipes containing multiple serovars of this species
(Peer reviewed; Journal article, 2023)An important challenge relating to clinical diagnostics of the foodborne pathogen Shiga toxin-producing E. coli (STEC), is that PCR-detection of the shiga-toxin gene (stx) in DNA from stool samples can be accompanied by a ... -
A preliminary study on the potential of Nanopore MinION and Illumina MiSeq 16S rRNA gene sequencing to characterize building-dust microbiomes
(Scientific Reports;10, Article number: 3209 (2020), Journal article; Peer reviewed, 2020-01-30)There is a growing awareness of the importance of indoor microbiomes for human health. Given their complexity, these microbiomes can only be adequately surveyed using high throughput sequencing techniques. Oxford Nanopore's ... -
TaME-seq: An efficient sequencing approach for characterisation of HPV genomic variability and chromosomal integration
(Scientific Reports;9, Article number: 524 (2019), Journal article; Peer reviewed, 2018-11-26)HPV genomic variability and chromosomal integration are important in the HPV-induced carcinogenic process. To uncover these genomic events in an HPV infection, we have developed an innovative and cost-effective sequencing ... -
Transcription factor PAX6 as a novel prognostic factor and putative tumour suppressor in non-small cell lung cancer
(Scientific Reports;Volume 8, Article number: 5059 (2018), Journal article; Peer reviewed, 2018-03-22)Lung cancer is the leading cause of cancer deaths. Novel predictive biomarkers are needed to improve treatment selection and more accurate prognostication. PAX6 is a transcription factor with a proposed tumour suppressor ... -
Utility of Tear Osmolarity Measurement in Diagnosis of Dry Eye Disease
(Scientific Reports;10, Article number: 5542 (2020), Journal article; Peer reviewed, 2020-03-26)The prevalence of dry eye disease is high worldwide and poses a great burden on patients’ daily lives. Accurate diagnosis of the disease is important, and it requires application of various methods. Hyperosmolarity is ... -
Utilization of lactic acid in human myotubes and interplay with glucose and fatty acid metabolism
(Scientific Reports;8, Article number: 9814 (2018), Journal article; Peer reviewed, 2018-06-29)Once assumed only to be a waste product of anaerobe glycolytic activity, lactate is now recognized as an energy source in skeletal muscles. While lactate metabolism has been extensively studied in vivo, underlying cellular ...