Browsing HV - Institutt for naturvitenskapelige helsefag by Title
Now showing items 164-183 of 428
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Hallmarks of primary headache: part 1 – migraine
(Peer reviewed; Journal article, 2024)Background and aim Migraine is a common disabling conditions which, globally, affects 15.2% of the population. It is the second cause of health loss in terms of years lived with disability, the first among women. Despite ... -
Halved contrast medium dose in lower limb dual-energy computed tomography angiography—a randomized controlled trial
(Peer reviewed; Journal article, 2023)Objectives To compare vascular attenuation (VA) of an experimental half iodine-load dual-layer spectral detector CT (SDCT) lower limb computed tomography angiography (CTA) with control (standard iodine-load conventional ... -
Hb Aalesund (HBA2: c.400_406delAGCACCG), an Unstable α-Globin Variant Found in a Norwegian Patient Causing Moderate Hemolytic Anemia and Falsely High Hb A1c Using Ion Exchange High Performance Liquid Chromatography.
(Hemoglobin;Volume 43, Issue 2, Journal article; Peer reviewed, 2019-04-03)A new unstable hemoglobin (Hb) variant, named Hb Aalesund, was detected during Hb A1c measurement in a patient with a nearly compensated hemolytic anemia. Sequencing of the α-globin genes revealed a 7 bp deletion in exon ... -
Health-related quality of life in adolescents with persistent pain and the mediating role of self-efficacy: a cross-sectional study
(Health and Quality of Life Outcomes;18, Article number: 19 (2020), Journal article; Peer reviewed, 2020-01-30)Background: Persistent pain has a high prevalence among adolescents. Pain has been shown to reduce all aspects of the adolescent’s health-related quality of life (HRQOL). In adult patients with pain, self-efficacy has ... -
Health‑related quality of life is strongly associated with self‑efficacy, self‑esteem, loneliness, and stress in 14–15‑year‑old adolescents: a cross‑sectional study
(Health and Quality of Life Outcomes;18, Article number: 352 (2020), Journal article; Peer reviewed, 2020-11-02)Background: To enhance and better understand health-related quality of life (HRQOL) in adolescents, it is important to study factors associated with HRQOL. The present study aimed to assess possible associations between ... -
Hemoglobinopathy gone astray—three novel forms of α-thalassemia in Norwegian patients characterized by quantitative real-time PCR and DNA sequencing
(Scandinavian Journal of Clinical and Laboratory Investigation;Volume 81, 2021 - Issue 8, Peer reviewed; Journal article, 2021-11-18)α-thalassemia is one of the most common monogenic diseases worldwide and is caused by reduced or absent synthesis of α-globin chains, most commonly due to deletions of one or more of the α-globin genes. α-thalassemia occurs ... -
How does botulinum toxin inhibit itch?
(Toxins;Volume 14 / Issue 10, Peer reviewed; Journal article, 2022)Two decades after reports of the anti-pruritic effects of botulinum neurotoxins (BoNTs), there is still no approved product for the anti-itch indication of BoNTs, and most clinical case reports still focus on the off-label ... -
HPV Genotyping of Modified General Primer-Amplicons Is More Analytically Sensitive and Specific by Sequencing than by Hybridization
(Journal article; Peer reviewed, 2017)Sensitive and specific genotyping of human papillomaviruses (HPVs) is important for population-based surveillance of carcinogenic HPV types and for monitoring vaccine effectiveness. Here we compare HPV genotyping by Next ... -
HPV16 and HPV18 type-specific APOBEC3 and integration profiles in different diagnostic categories of cervical samples
(Tumour Virus Research;Volume 12, December 2021, 200221, Peer reviewed; Journal article, 2021-07-14)Human papillomavirus (HPV) 16 and 18 are the most predominant types in cervical cancer. Only a small fraction of HPV infections progress to cancer, indicating that additional factors and genomic events contribute to the ... -
HPV16 whole genome minority variants in persistent infections from young Dutch women
(Journal of Clinical Virology;Volume 119, October 2019, Journal article; Peer reviewed, 2019-08-09)Background: Chronic infections by one of the oncogenic human papillomaviruses (HPVs) are responsible for near 5% of the global cancer burden and HPV16 is the type most often found in cancers. HPV genomes displayunexpected ... -
Human brain organoids in migraine research: Pathogenesis and drug development
(Peer reviewed; Journal article, 2023) -
Human Brain Organoids in the Preclinical Phase of Drug Development for Migraine
(Peer reviewed; Journal article, 2024)Developing drugs for brain disorders poses significant hurdles. These challenges stem from the scarcity of optimal models for preclinical drug testing and the often observed lack of translation from preclinical to human ... -
Hva finnes på innsiden av kranarmaturer?
(Vann;, Journal article; Peer reviewed, 2012)Innsiden av vannkraner kommer i kontakt med både mikrober som er til stede i drikkevann og de som finnes på hender, matrester og i luften. En hypotese er at kranbiofilmer kan være tilholdssted for sykdomsfremkallende ... -
Hvor robust er samsvaret mellom respondering på matching-to-sample tester og sorteringstester?
(Norsk tidsskrift for atferdsanalyse;Nummer 2 (VINTER 2018), Journal article; Peer reviewed, 2018)Formålet med dette eksperimentet var å undersøke om samsvaret mellom resultatene på en matching-to-sample (MTS) test og sorteringstester også er gjeldende ved bruk en Many-to-One (MTO) treningsstruktur. Vi ønsket å gjøre ... -
Hyperactivation of NF-κB via the MEK signaling is indispensable for the inhibitory effect of cAMP on DNA damage-induced cell death.
(Molecular Cancer;10 (45), Journal article; Peer reviewed, 2011-04-21)With cAMP signaling having a profound inhibitory effect on DNA damage-induced apoptosis in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cells, understanding how this signaling pathway affects the survival capacity ... -
'I try not to bother the residents too much' - the use of capillary blood glucose measurements in nursing homes
(Journal article; Peer reviewed, 2016)Background Capillary blood glucose measurements are regularly used for nursing home residents with diabetes. The usefulness of these measurements relies on clear indications for use, correct measurement techniques, ... -
Identification of 19 new risk loci and potential regulatory mechanisms influencing susceptibility to testicular germ cell tumor
(Nature Genetics;Volume 49, Issue 7, Journal article; Peer reviewed, 2017-06-12)Genome-wide association studies (GWAS) have transformed our understanding of testicular germ cell tumour (TGCT) susceptibility but much of the heritability remains unexplained. Here we report a new GWAS, a meta-analysis ... -
Identification of a novel polymorphism associated with reduced clozapine concentration in schizophrenia patients—a genome-wide association study adjusting for smoking habits
(Translational Psychiatry; 10, Article number: 198 (2020), Journal article; Peer reviewed, 2020-06-19)Clozapine (CLZ) is the superior antipsychotic drug for treatment of schizophrenia, but exhibits an extensive interpatient pharmacokinetic variability. Here, we conducted a genome-wide association study (GWAS) of CLZ serum ... -
Identification of differentially expressed Atlantic salmon miRNAs responding to salmonid alphavirus (SAV) infection
(Journal article; Peer reviewed, 2017)Background MicroRNAs (miRNAs) control multiple biological processes including the innate immune responses by negative post-transcriptional regulation of gene expression. As there were no studies on the role(s) of miRNAs ... -
Identification of required capabilities of digital health ecosystems when preventing and managing non-communicable diseases
(Digital Health;, Peer reviewed; Journal article, 2024)Objective: Non-communicable diseases cause annual mortality for 41 million people worldwide. These diseases include coronary heart disease, cancer, stroke, diabetes, and musculoskeletal as well as mental disorders. Innovation ...