Browsing HV - Institutt for naturvitenskapelige helsefag by Title
Now showing items 252-271 of 395
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Pharmacokinetic variability and clinical use of lacosamide in children and adolescents in Denmark and Norway
(Therapeutic Drug Monitoring;41 (3): 340–347, JUNE 2019, Journal article; Peer reviewed, 2019-01-01)Background: The indication for the antiepileptic drug (AED) lacosamide (LCM) was recently extended to include children from the age of four. Real-life data on the use and serum concentrations of LCM in children and ... -
Pharmacological aspects of antiseizure medications: From basic mechanisms to clinical considerations of drug interactions and use of therapeutic drug monitoring
(Journal article; Peer reviewed, 2023)Antiseizure medications (ASMs) are the cornerstone of treatment for patients with epilepsy. Several new ASMs have recently been introduced to the market, making it possible to better tailor the treatment of epilepsy, as ... -
Pharmacology and drug interactions of cannabinoids
(Epileptic Disorders;Vol. 22, Supplement 1, Journal article; Peer reviewed, 2020)Cannabinoids include a variety of substances, of which cannabidiol (CBD) is the main substance investigated for the treatment of epilepsy, and this will be the focus in the present review. CBD preparations exist in various ... -
Polymorphisms in hormone metabolism and growth factor genes and mammographic density in Norwegian postmenopausal hormone therapy users and non-users
(Breast Cancer Research;14 (R135), Journal article; Peer reviewed, 2012-10-27)Introduction Mammographic density (MD) is one of the strongest known breast cancer risk factors. Estrogen and progestin therapy (EPT) has been associated with increases in MD. Dense breast tissue is characterized by ... -
PopAffiliator: online calculator for individual affiliation to a major population group based on 17 autosomal short tandem repeat genotype profile.
(International journal of legal medicine;124, Journal article; Peer reviewed, 2010-06-16)Because of their sensitivity and high level of discrimination, short tandem repeat (STR) maker systems are currently the method of choice in routine forensic casework and data banking, usually in multiplexes up to 15–17 ... -
A population study of Norwegian psychiatric patients referred for clinical brain scanning
(BJPsych Open;Volume 4, Issue 3, Journal article; Peer reviewed, 2018-05-08)Background Patients with psychiatric conditions are often referred for a brain scan during the course of their diagnostic workup. Aims The aim of our study is to determine frequency and type of organic brain pathology, ... -
Positioning of community pharmacists in interactions with general practitioners and patients regarding prescribing and using antibiotics
(Journal of Interprofessional Care;, Peer reviewed; Journal article, 2023)Interprofessional collaboration between general practitioners (GPs) and community pharmacists (CPs) is important for ensuring antibiotics are used correctly and combating antibiotic resistance. The study’s main objective ... -
Praksisstudienes omfang og organisering i bioingeniørutdanningen
(Peer reviewed; Journal article, 2022)Siden 2005 har omfang og innhold i bioingeniørutdanningen vært definert av en nasjonal rammeplan for å sikre likeverdig sluttkompetanse for alle kandidater. Fra 2019 ble en ny forskrift om nasjonale retningslinjer ... -
Praksisstudienes omfang og organisering i bioingeniørutdanningen
(Peer reviewed; Journal article, 2022)Siden 2005 har omfang og innhold i bioingeniørutdanningen vært definert av en nasjonal rammeplan for å sikre likeverdig sluttkompetanse for alle kandidater. Fra 2019 ble en ny forskrift om nasjonale retningslinjer fastsatt. ... -
Pre-cementation procedures' effect on dental zirconias with different yttria content
(Dental Materials;Volume 37, Issue 9, Peer reviewed; Journal article, 2021-07-28)Objective: Several pre-cementation procedures have been advocated to enhance adhesion between zirconia and resin-based cement. There is, however, limited documentation on how these pre-treatments affect the strength of ... -
Pre-dosing with lilotomab prior to therapy with 177Lu-lilotomab satetraxetan significantly increases the ratio of tumor to red marrow absorbed dose in non-Hodgkin lymphoma patients
(European Journal of Nuclear Medicine and Molecular Imaging;July 2018, Volume 45, Issue 7, Journal article; Peer reviewed, 2018-02-22)Purpose: 177Lu-lilotomab satetraxetan is a novel anti-CD37 antibody radionuclide conjugate for the treatment of non-Hodgkin lymphoma (NHL). Four arms with different combinations of pre-dosing and pre-treatment have been ... -
Pre-stroke cognitive impairment is associated with vascular imaging pathology: a prospective observational study
(BMC Geriatrics;21, Article number: 362 (2021), Peer reviewed; Journal article, 2021-06-14)Background: Chronic brain pathology and pre-stroke cognitive impairment (PCI) is predictive of post-stroke dementia. The aim of the current study was to measure pre-stroke neurodegenerative and vascular disease burden found ... -
Prediction of Age Older than 18 Years in Sub-adults by MRI Segmentation of 1st and 2nd Molars
(Journal article; Peer reviewed, 2023)Purpose To investigate prediction of age older than 18 years in sub-adults using tooth tissue volumes from MRI segmenta- tion of the entire 1st and 2nd molars, and to establish a model for combining information from two ... -
Prediction of CYP2D6 poor metabolizers by measurements of solanidine and metabolites—a study in 839 patients with known CYP2D6 genotype
(Peer reviewed; Journal article, 2023)Purpose Poor metabolizers (PMs) of the highly polymorphic enzyme CYP2D6 are usually at high risk of adverse effects during standard recommended dosing of CYP2D6-metabolized drugs. We studied if the metabolism of solanidine, ... -
A preliminary study of the use of MinION sequencing to specifcally detect Shiga toxin‑producing Escherichia coli in culture swipes containing multiple serovars of this species
(Peer reviewed; Journal article, 2023)An important challenge relating to clinical diagnostics of the foodborne pathogen Shiga toxin-producing E. coli (STEC), is that PCR-detection of the shiga-toxin gene (stx) in DNA from stool samples can be accompanied by a ... -
A preliminary study on the potential of Nanopore MinION and Illumina MiSeq 16S rRNA gene sequencing to characterize building-dust microbiomes
(Scientific Reports;10, Article number: 3209 (2020), Journal article; Peer reviewed, 2020-01-30)There is a growing awareness of the importance of indoor microbiomes for human health. Given their complexity, these microbiomes can only be adequately surveyed using high throughput sequencing techniques. Oxford Nanopore's ... -
Presence of Small-Conductance Calcium-Activated Potassium (SK) Channels in the Central and Peripheral Nervous Systems and Their Role in Health and Disease
(Journal of Integrative Neuroscience (JIN);, Peer reviewed; Journal article, 2023)Potassium (K+) channels establish and maintain the resting potential of most living cells. Their activity is predominantly regulated by the membrane voltage or the K+ gradient across the cell membrane. However, many cells ... -
A Preservative-Free Approach – Effects on Dry Eye Signs and Symptoms After Cataract Surgery
(Peer reviewed; Journal article, 2024)Purpose: To compare the effect of treatment with preservative-free dexamethasone, NSAIDs and trehalose/hyaluronic acid eye drops with the preservative benzalkonium chloride containing dexamethasone and NSAIDs after cataract ... -
Prevalence of Dry Eye Disease Among Individuals Scheduled for Cataract Surgery in a Norwegian Cataract Clinic
(Clinical Ophthalmology;, Peer reviewed; Journal article, 2023)Purpose: To determine the prevalence of dry eye disease (DED) in patients scheduled for cataract surgery in a Norwegian eye clinic. Patients and Methods: 218 patients scheduled for cataract surgery were examined for DED ... -
Pro-arrhythmic effect of escitalopram and citalopram at serum concentrations commonly observed in older patients – a study based on a cohort of 19,742 patients
(Peer reviewed; Journal article, 2023)Background For a decade, patients have been advised against using high citalopram- and escitalopram-doses due to risk for ventricular arrhythmia and cardiac arrest. Still, these drugs are widely used to treat depression ...