• Global prevalence and genotype distribution of hepatitis C virus infection in 2015: a modelling study 

      Blach, Sarah; Zeuzem, Stefan; Manns, Michael; Altraif, Ibrahim; Duberg, Ann-Sofi; Muljono, David H; Waked, Imam; Alavian, Seyed M; Lee, Mei-Hsuan; Negro, Francesco; Abaalkhail, Faisal; Abdou, Ahmed; Abdulla, Maheeba; Rached, Antoine Abou; Aho, Inka; Akarca, Ulus; Ghazzawi, Imad Al; Kaabi, Saad Al; Lawati, Faryal Al; Namaani, Khalid Al; Serkal, Youssif Al; Al-Busafi, Said A; Al-Dabal, Layla; Aleman, Soo; Alghamdi, Abdullah S; Aljumah, Abdulrahman A; Al-Romaihi, Hamad E; Andersson, Monique I; Arendt, Vic; Arkkila, Perttu; Assiri, Abdullah M; Baatarkhuu, Oidov; Bane, Abate; Ben-Ari, Ziv; Bergin, Colm; Bessone, Fernando; Bihl, Florian; Bizri, Abdul R; Blachier, Martin; Blasco, Antonio J; Mello, Carlos E Brandao; Bruggmann, Philip; Brunton, Cheryl R; Calinas, Filipe; Chan, Henry L Y; Chaudhry, Asad; Cheinquer, Hugo; Chen, Chien-Jen; Chien, Rong-Nan; Choi, Moon Seok; Christensen, Peer B; Chuang, Wan-Long; Chulanov, Vladimir; Cisneros, Laura; Clausen, Mette R; Cramp, Matthew E; Craxi, Antonio; Croes, Esther A; Dalgard, Olav (The Lancet Gastroenterology and Hepatology;2(3), Journal article; Peer reviewed, 2017-03)
      Background The 69th World Health Assembly approved the Global Health Sector Strategy to eliminate hepatitis C virus (HCV) infection by 2030, which can become a reality with the recent launch of direct acting antiviral ...
    • Health status in subjects with suspected obstructive sleep apnea and comparison with a general population 

      Beiske, Kornelia Katalin; Stavem, Knut (Scientific reports;8(1), Journal article; Peer reviewed, 2018-04-03)
      The purpose of this study was to assess health status (HS) in patients with clinical suspicion of obstructive sleep apnea (OSA) in order to estimate the dose response relationship between HS and OSA severity, and to ...
    • Impaired synaptic function is linked to cognition in Parkinson's disease 

      Selnes, Per; Stav, Ane Løvli; Johansen, Krisztina Kunszt; Bjørnerud, Atle; Coello, Sebastien Christopher; Auning, Eirik; Kalheim, Lisa Flem; Almdahl, Ina Selseth; Hessen, Erik; Zetterberg, Henrik; Blennow, Kaj; Årsland, Dag; Fladby, Tormod (Annals of Clinical and Translational Neurology;4(10), Journal article; Peer reviewed, 2017-08-31)
      Objective Cognitive impairment is frequent in Parkinson's disease, but the underlying mechanisms are insufficiently understood. Because cortical metabolism is reduced in Parkinson's disease and closely associated with ...
    • Inflammation and Mechanical Stress Stimulate Osteogenic Differentiation of Human Aortic Valve Interstitial Cells 

      Bogdanova, Mariia; Kostina, Aleksandra; Zihlavnikova, Katarina; Zabirnyk, Arsenii; Malashicheva, Anna; Stensløkken, Kåre-Olav; Sullivan, Gareth; Kaljusto, Mari-Liis; Kvitting, John Peder Escobar; Kostareva, Anna; Vaage, Ingvar Jarle; Rutkovskiy, Arkady (Frontiers in physiology;9, Journal article; Peer reviewed, 2018-11-20)
      Background: Aortic valve calcification is an active proliferative process, where interstitial cells of the valve transform into either myofibroblasts or osteoblast-like cells causing valve deformation, thickening of cusps ...
    • Left ventricular biomechanics in professional football players 

      von Lueder, Thomas Gero; Hodt, Anders; Gjerdalen, Gard Filip; Steine, Kjetil (Scandinavian journal of medicine & science in sports;28(1), Journal article; Peer reviewed, 2017-04-04)
      Chronic exercise induces adaptive changes of left ventricular (LV) ejection and filling capacities which may be detected by novel speckle‐tracking echocardiography (STE) and tissue Doppler imaging (TDI)‐based techniques. ...
    • Morbidity outcomes after surgical aortic valve replacement 

      Auensen, Andreas; Hussain, Amjad Iqbal; Bendz, Bjørn; Aaberge, Lars; Falk, Ragnhild Sørum; Hansen, Marte; Bye, Eva; Andreassen, Johanna; Beitnes, Jan Otto; Rein, Kjell Arne; Pettersen, Kjell I; Gullestad, Lars (Open Heart;4(1), Journal article; Peer reviewed, 2017-04-13)
      Objective In patients with mild to moderate operative risk, surgical aortic valve replacement (SAVR) is still the preferred treatment for patients with severe symptomatic aortic stenosis (AS). Aiming to broaden the knowledge ...
    • NAD+ in aging: molecular mechanisms and translational implications 

      Fang, Evandro Fei; Lautrup, Sofie; Hou, Yujun; Demarest, Tyler G; Croteau, Deborah L; Mattson, Mark P; Bohr, Vilhelm A (Trends in Molecular Medicine;23/10, Journal article; Peer reviewed, 2017-10)
      AB The coenzyme NAD+ is critical in cellular bioenergetics and adaptive stress responses. Its depletion has emerged as a fundamental feature of aging that may predispose to a wide range of chronic diseases. Maintenance of ...
    • Novel biomarkers of cardiovascular disease: Applications in clinical practice 

      Lyngbakken, Magnus; Myhre, Peder Langeland; Røsjø, Helge; Omland, Torbjørn (Critical reviews in clinical laboratory sciences;56(1), Journal article; Peer reviewed, 2018-11-20)
      Measurement of biomarkers has revolutionized the work-up of patients with suspected cardiovascular disease. The most widely used contemporary cardiovascular biomarkers are the natriuretic peptides in the diagnosis and ...
    • Novel serum and bile protein markers predict primary sclerosing cholangitis disease severity and prognosis 

      Vesterhus, Mette; Holm, Anders; Hov, Johannes Espolin Roksund; Nygård, Ståle; Schrumpf, Erik; Melum, Espen; Thorbjørnsen, Liv Wenche; Paulsen, Vemund; Lundin, Knut Erik Aslaksen; Dale, Inge; Gilja, Odd Helge; Zweers, Serge J.; Vatn, Morten H.; Schaap, Frank G.; Jansen, Peter L. M.; Ueland, Thor; Røsjø, Helge; Moum, Bjørn; Ponsioen, Cyriel Y.; Boberg, Kirsten Muri; Färkkilä, Martti; Karlsen, Tom Hemming; Lund-Johansen, Fridtjof (Journal of hepatology;66(6), Journal article; Peer reviewed, 2017-02-02)
      Background & Aims Prognostic biomarkers are lacking in primary sclerosing cholangitis, hampering patient care and the development of therapy. We aimed to identify novel protein biomarkers of disease severity and prognosis ...
    • Overall Survival in Renal Cell Carcinoma after Introduction of Targeted Therapies: A Norwegian Population-Based Study 

      Beisland, Christian; Johannesen, Tom Bjørge; Klepp, Olbjørn; Axcrona, Ulrika; Torgersen, Knut Martin; Kowalski, Jan; Solli, Oddvar; Sandin, Rickard; Oldenburg, Jan (OncoTargets and therapy;10, Journal article; Peer reviewed, 2017-01-16)
      Background: This population-wide retrospective, non-interventional registry study assessed changes in overall survival (OS) and factors influencing OS in Norwegian patients with renal cell carcinoma (RCC). Methods: Two ...
    • Patient knowledge on stroke risk factors, symptoms and treatment options 

      Faiz, Kashif Waqar; Sundseth, Antje; Thommessen, Bente; Rønning, Ole M. (Vascular health and risk management;14, Journal article; Peer reviewed, 2018-02-07)
      Background: Public campaigns focus primarily on stroke symptom and risk factor knowledge, but patients who correctly recognize stroke symptoms do not necessarily know the reason for urgent hospitalization. The aim of this ...
    • Physical distress is associated with cardiovascular events in a high 

      Einvik, Gunnar; Ekeberg, Øivind; Klemsdal, Tor O; Sandvik, Leiv; Hjerkinn, Elsa M (BMC Cardiovascular Disorders;9(14), Journal article; Peer reviewed, 2009-03-30)
      Background: Self-reported health perceptions such as physical distress and quality of life are suggested independent predictors of mortality and morbidity in patients with established cardiovascular disease. This study ...
    • Plasma marine n-3 polyunsaturated fatty acids and cardiovascular risk factors: data from the ACE 1950 study 

      Chandra, Anupam; Røsjø, Helge; Eide, Ivar Anders; Vigen, Thea; Ihle-Hansen, Håkon; Orstad, Eivind Bjørkan; Rønning, Ole M; Lyngbakken, Magnus; Berge, Trygve; Schmidt, Erik Berg; Omland, Torbjørn; Tveit, Arnljot; Svensson, My Hanna Sofie (European journal of nutrition;, Journal article; Peer reviewed, 2019-05-23)
      Abstract Purpose A high intake of marine n-3 polyunsaturated fatty acids (PUFAs) might improve cardiovascular (CV) health. We conducted a cross-sectional study to investigate associations between plasma phospholipid ...
    • Policy responses to hepatitis C in the Nordic countries: Gaps and discrepant reporting in the Hep-Nordic study 

      Safreed-Harmon, Kelly; Hetherington, Kristina L.; Aleman, Soo; Alho, Hannu; Dalgard, Olav; Frisch, Tove; Gottfredsson, Magnus; Weis, Nina; Lazarus, Jeffrey V. (PloS ONE;13(1), Journal article; Peer reviewed, 2018-01-30)
      Background and aims In the Nordic countries (Denmark, Finland, Iceland, Norway, Sweden), the prevalence of chronic hepatitis C virus (HCV) infection is relatively low in the general population, but is much higher among ...
    • Predictive value of C-reactive protein in patients treated with sunitinib for metastatic clear cell renal cell carcinoma 

      Pilskog, Martin; Beisland, Christian; Akslen, Lars A; Bostad, Leif; Haug, Åse; Heinrich, Daniel; Hjelle, Karin Margrethe; Straume, Oddbjørn (BMC Urology;17(1), Journal article; Peer reviewed, 2017-08-31)
      Background Sunitinib has become mainstay first line treatment for patients with metastatic renal clear cell carcinoma (mRCC). Still, useful predictive markers of response are lacking and urgently needed for clinical ...
    • Prevalence of carotid plaque in a 63- to 65-Year-Old Norwegian cohort from the general population: The ACE (Akershus Cardiac Examination) 1950 study 

      Ihle-Hansen, Håkon; Vigen, Thea; Ihle-Hansen, Hege; Rønning, Ole M.; Berge, Trygve; Thommessen, Bente; Lyngbakken, Magnus; Orstad, Eivind Bjørkan; Enger, Steve; Nygård, Ståle; Røsjø, Helge; Tveit, Arnljot (Journal of the American Heart Association;7(10), Journal article; Peer reviewed, 2018-05-08)
      Background New data on extracranial carotid atherosclerosis are needed, as improved ultrasound techniques may detect more atherosclerosis, the definition of plaque has changed over the years, and better cardiovascular ...
    • Research priorities to achieve universal access to hepatitis C prevention, management and direct-acting antiviral treatment among people who inject drugs. 

      Grebely, Jason; Bruneau, Julie; Lazarus, Jeffrey; Dalgard, Olav; Bruggmann, Philip; Treloar, Carla; Hickman, Matthew; Hellard, Margaret; Roberts, Teri; Crooks, Levinia; Midgard, Håvard; Larney, Sarah; Degenhardt, Louisa; Alho, Hannu; Byrne, Jude; Dillon, John F; Feld, Jordan J; Foster, Graham; Goldberg, David E; Lloyd, Andrew R; Reimer, Jens; Robaeys, Geert; Torrens, Marta; Wright, Nat; Maremmani, Icro; Norton, Brianna L; Litwin, Alain H; Dore, Gregory J (International Journal of Drug Policy;47, Journal article; Peer reviewed, 2017-09)
      Globally, it is estimated that 71.1 million people have chronic hepatitis C virus (HCV) infection, including an estimated 7.5 million people who have recently injected drugs (PWID). There is an additional large, but ...
    • Sofosbuvir and velpatasvir for hepatitis C virus infection in people with recent injection drug use (SIMPLIFY): an open-label, single-arm, phase 4, multicentre trial 

      Grebely, Jason; Dalgard, Olav; Conway, Brian; Cunningham, Evan B.; Bruggmann, Philip; Hajarizadeh, Behzad; Amin, Janaki; Bruneau, Julie; Hellard, Margaret; Litwin, Alain H.; Marks, Phillippa; Quiene, Sophie; Siriragavan, Sharmila; Applegate, Tanya L.; Swan, Tracy; Byrne, Jude; Lacalamita, Melanie; Dunlop, Adrian; Matthews, Gail V.; Powis, Jeff; Shaw, David; Thurnheer, Maria Christine; Weltmann, Martin; Kronborg, Ian; Cooper, Curtis; Feld, Jordan J.; Fraser, Chris; Dillon, John F.; Read, Phillip; Gane, Edward; Dore, Gregory J. (The lancet Gastroenterology & hepatology;3(3), Journal article; Peer reviewed, 2018-03)
      Background Despite revised guidelines that no longer exclude people who inject drugs (PWID) from treatment for hepatitis C virus (HCV) infection, many clinicians are reluctant to treat recent PWID. This study aimed to ...
    • Sofosbuvir based treatment of chronic hepatitis C genotype 3 infections - a Scandinavian real-life study 

      Dalgard, Olav; Weiland, Ola; Noraberg, Geir; Karlsen, Lars Normann; Heggelund, Lars; Färkkilä, Martti; Balselv, Ulla; Berlard, Erika; Øvrehus, Anne; Kjær, Mette Skalshøi; Krarup, Henrik; Røge, Birgit Thorup; Hallager, Sofie; Madsen, Lone G; Laursen, Alex Lund; Lagging, Martin; Weis, Nina (PLoS ONE;12(7), Journal article; Peer reviewed, 2017-07-13)
      Background and aims Chronic hepatitis C virus (HCV) genotype 3 infection with advanced liver disease has emerged as the most challenging to treat. We retrospectively assessed the treatment outcome of sofosbuvir (SOF) based ...
    • Subjective cognitive impairment is a predominantly benign condition in memory clinic patients followed for 6 years: The Gothenburg-oslo MCI Study 

      Hessen, Erik; Eckerström, Marie; Nordlund, Arto; Almdahl, Ina; Stålhammar, Jacob; Bjerke, Maria; Eckerström, Carl; Göthlin, Mattias; Fladby, Tormod; Reinvang, Ivar; Wallin, Anders (Dementia and Geriatric Cognitive Disorders Extra;7(1), Journal article; Peer reviewed, 2017-02-02)
      Background/Aims: In the quest for prevention or treatment, there is a need to find early markers for preclinical dementia. This study observed memory clinic patients with subjective cognitive impairment (SCI) and normal ...