Recent Submissions

  • Plasma marine n-3 polyunsaturated fatty acids and cardiovascular risk factors: data from the ACE 1950 study 

    Chandra, Anupam; Røsjø, Helge; Eide, Ivar Anders; Vigen, Thea; Ihle-Hansen, Håkon; Orstad, Eivind Bjørkan; Rønning, Ole M; Lyngbakken, Magnus; Berge, Trygve; Schmidt, Erik Berg; Omland, Torbjørn; Tveit, Arnljot; Svensson, My Hanna Sofie (European journal of nutrition;, Journal article; Peer reviewed, 2019-05-23)
    Abstract Purpose A high intake of marine n-3 polyunsaturated fatty acids (PUFAs) might improve cardiovascular (CV) health. We conducted a cross-sectional study to investigate associations between plasma phospholipid ...
  • Circulating microRNAs as predictive biomarkers of myocardial infarction: Evidence from the HUNT study 

    Velle-Forbord, Torbjørn; Eidlaug, Maria; Debik, Julia Barbara; Sæther, Julia Caroline; Follestad, Turid; Nauman, Javaid; Gigante, Bruna; Røsjø, Helge; Omland, Torbjørn; Langaas, Mette; Bye, Anja (Atherosclerosis;289, Journal article; Peer reviewed, 2019-10)
    Abstract Background and aims Several risk prediction models for coronary heart disease (CHD) are available today, however, they only explain a modest proportion of the incidence. Circulating microRNAs (miRs) have ...
  • NAD+ in aging: molecular mechanisms and translational implications 

    Fang, Evandro Fei; Lautrup, Sofie; Hou, Yujun; Demarest, Tyler G; Croteau, Deborah L; Mattson, Mark P; Bohr, Vilhelm A (Trends in Molecular Medicine;23/10, Journal article; Peer reviewed, 2017-10)
    AB The coenzyme NAD+ is critical in cellular bioenergetics and adaptive stress responses. Its depletion has emerged as a fundamental feature of aging that may predispose to a wide range of chronic diseases. Maintenance of ...
  • Novel serum and bile protein markers predict primary sclerosing cholangitis disease severity and prognosis 

    Vesterhus, Mette; Holm, Anders; Hov, Johannes Espolin Roksund; Nygård, Ståle; Schrumpf, Erik; Melum, Espen; Thorbjørnsen, Liv Wenche; Paulsen, Vemund; Lundin, Knut Erik Aslaksen; Dale, Inge; Gilja, Odd Helge; Zweers, Serge J.; Vatn, Morten H.; Schaap, Frank G.; Jansen, Peter L. M.; Ueland, Thor; Røsjø, Helge; Moum, Bjørn; Ponsioen, Cyriel Y.; Boberg, Kirsten Muri; Färkkilä, Martti; Karlsen, Tom Hemming; Lund-Johansen, Fridtjof (Journal of hepatology;66(6), Journal article; Peer reviewed, 2017-02-02)
    Background & Aims Prognostic biomarkers are lacking in primary sclerosing cholangitis, hampering patient care and the development of therapy. We aimed to identify novel protein biomarkers of disease severity and prognosis ...
  • Left ventricular biomechanics in professional football players 

    von Lueder, Thomas Gero; Hodt, Anders; Gjerdalen, Gard Filip; Steine, Kjetil (Scandinavian journal of medicine & science in sports;28(1), Journal article; Peer reviewed, 2017-04-04)
    Chronic exercise induces adaptive changes of left ventricular (LV) ejection and filling capacities which may be detected by novel speckle‐tracking echocardiography (STE) and tissue Doppler imaging (TDI)‐based techniques. ...
  • B-cell composition in the blood and cerebrospinal fluid of multiple sclerosis patients treated with dimethyl fumarate 

    Høglund, Rune Alexander; Polak, Justyna; Vartdal, Frode; Holmøy, Trygve; Lossius, Andreas Lunde (Multiple sclerosis and related disorders;26, Journal article; Peer reviewed, 2018-08-30)
    Background:B cells may contribute to the immunopathogenesis of multiple sclerosis (MS). Dimethyl fumarate(DMF) has recently been shown to reduce the frequency of memory B cells in blood, but it is not known whetherthe drug ...
  • Cardiac troponin and natriuretic peptide analytical interferences from hemolysis and biotin: Educational aids from the IFCC Committee on Cardiac Biomarkers (IFCC C-CB) 

    Saenger, Amy K; Jaffe, Allan S.; Body, Richard; Collinson, Paul O.; Kavsak, Peter A.; Lam, Carolyn S. P.; Lefèvre, Guillaume; Omland, Torbjørn; Ordóñez-Llanos, Jordi; Pulkki, Kari; Apple, Fred S. (Clinical Chemistry and Laboratory Medicine (CCLM);57(5), Journal article; Peer reviewed, 2018-06-10)
    Two interferences recently brought to the forefront as patient safety issues include hemolysis (hemoglobin) and biotin (vitamin B7). The International Federation for Clinical Chemistry Committee on Cardiac Biomarkers ...
  • Novel biomarkers of cardiovascular disease: Applications in clinical practice 

    Lyngbakken, Magnus; Myhre, Peder Langeland; Røsjø, Helge; Omland, Torbjørn (Critical reviews in clinical laboratory sciences;56(1), Journal article; Peer reviewed, 2018-11-20)
    Measurement of biomarkers has revolutionized the work-up of patients with suspected cardiovascular disease. The most widely used contemporary cardiovascular biomarkers are the natriuretic peptides in the diagnosis and ...
  • Sofosbuvir and velpatasvir for hepatitis C virus infection in people with recent injection drug use (SIMPLIFY): an open-label, single-arm, phase 4, multicentre trial 

    Grebely, Jason; Dalgard, Olav; Conway, Brian; Cunningham, Evan B.; Bruggmann, Philip; Hajarizadeh, Behzad; Amin, Janaki; Bruneau, Julie; Hellard, Margaret; Litwin, Alain H.; Marks, Phillippa; Quiene, Sophie; Siriragavan, Sharmila; Applegate, Tanya L.; Swan, Tracy; Byrne, Jude; Lacalamita, Melanie; Dunlop, Adrian; Matthews, Gail V.; Powis, Jeff; Shaw, David; Thurnheer, Maria Christine; Weltmann, Martin; Kronborg, Ian; Cooper, Curtis; Feld, Jordan J.; Fraser, Chris; Dillon, John F.; Read, Phillip; Gane, Edward; Dore, Gregory J. (The lancet Gastroenterology & hepatology;3(3), Journal article; Peer reviewed, 2018-03)
    Background Despite revised guidelines that no longer exclude people who inject drugs (PWID) from treatment for hepatitis C virus (HCV) infection, many clinicians are reluctant to treat recent PWID. This study aimed to ...
  • Tested and reported executive problems in children and youth epilepsy 

    Hessen, Erik; Alfstad, Kristin Åshild; Torgersen, Halvor S.; Lossius, Morten (Brain and Behavior;8(5), Journal article; Peer reviewed, 2018-04-16)
    Objectives Executive problems in children and youth with epilepsy influence their ability to handle important aspects of daily life activities. The present study sought to explore factors associated with executive problems ...
  • Health status in subjects with suspected obstructive sleep apnea and comparison with a general population 

    Beiske, Kornelia Katalin; Stavem, Knut (Scientific reports;8(1), Journal article; Peer reviewed, 2018-04-03)
    The purpose of this study was to assess health status (HS) in patients with clinical suspicion of obstructive sleep apnea (OSA) in order to estimate the dose response relationship between HS and OSA severity, and to ...
  • Patient knowledge on stroke risk factors, symptoms and treatment options 

    Faiz, Kashif Waqar; Sundseth, Antje; Thommessen, Bente; Rønning, Ole M. (Vascular health and risk management;14, Journal article; Peer reviewed, 2018-02-07)
    Background: Public campaigns focus primarily on stroke symptom and risk factor knowledge, but patients who correctly recognize stroke symptoms do not necessarily know the reason for urgent hospitalization. The aim of this ...
  • Prevalence of carotid plaque in a 63- to 65-Year-Old Norwegian cohort from the general population: The ACE (Akershus Cardiac Examination) 1950 study 

    Ihle-Hansen, Håkon; Vigen, Thea; Ihle-Hansen, Hege; Rønning, Ole M.; Berge, Trygve; Thommessen, Bente; Lyngbakken, Magnus; Orstad, Eivind Bjørkan; Enger, Steve; Nygård, Ståle; Røsjø, Helge; Tveit, Arnljot (Journal of the American Heart Association;7(10), Journal article; Peer reviewed, 2018-05-08)
    Background New data on extracranial carotid atherosclerosis are needed, as improved ultrasound techniques may detect more atherosclerosis, the definition of plaque has changed over the years, and better cardiovascular ...
  • Fatigue is not associated with vitamin D deficiency in inflammatory bowel disease patients 

    Frigstad, Svein Oskar; Høivik, Marte Lie; Jahnsen, Jørgen; Småstuen, Milada Cvancarova; Grimstad, Tore; Berset, Ingrid Prytz; Huppertz-Hauss, Gert; Hovde, Øistein; Bernklev, Tomm; Moum, Bjørn; Jelsness-Jørgensen, Lars-Petter (World journal of gastroenterology;24(29), Journal article; Peer reviewed, 2018-08-07)
    AIM To investigate if vitamin D deficiency is associated with fatigue in patients with inflammatory bowel disease (IBD). METHODS IBD patients were recruited from nine hospitals in the southeastern and western regions ...
  • Bioavailable Testosterone Is Positively Associated With Bone Mineral Density in Male Kidney Transplantation Candidates 

    Jørgensen, Hanne Skou; Winther, Simon; Bøttcher, Morten; Hauge, Ellen-Margrethe; Rejnmark, Lars; Svensson, My Hanna Sofie; Ivarsen, Per (Kidney international reports;3(3), Journal article; Peer reviewed, 2018-05)
    Introduction Low levels of sex hormones are common in patients with chronic kidney disease (CKD) and may be a contributing factor to bone fragility. We investigated associations between levels of sex hormones and bone ...
  • Adherence to subcutaneous interferon beta-1a treatment using an electronic injection device: a prospective open-label scandinavian noninterventional study (The scansmart study) 

    Pedersen, Elena Didenko; Stenager, Egon; Vadgaard, J. L.; Jensen, Michael Broksgaard; Schmid, Roman; Meland, Nils; Magnussen, Gry Irene; Frederiksen, Jette Lautrup (Patient preference and adherence;12, Journal article; Peer reviewed, 2018-04-19)
    Background: Disease modifying drugs help control the course of relapsing remitting multiple sclerosis (RRMS); however, good adherence is needed for long-term outcomes. Objective: To evaluate patient adherence to treatment ...
  • Inflammation and Mechanical Stress Stimulate Osteogenic Differentiation of Human Aortic Valve Interstitial Cells 

    Bogdanova, Mariia; Kostina, Aleksandra; Zihlavnikova, Katarina; Zabirnyk, Arsenii; Malashicheva, Anna; Stensløkken, Kåre-Olav; Sullivan, Gareth; Kaljusto, Mari-Liis; Kvitting, John Peder Escobar; Kostareva, Anna; Vaage, Ingvar Jarle; Rutkovskiy, Arkady (Frontiers in physiology;9, Journal article; Peer reviewed, 2018-11-20)
    Background: Aortic valve calcification is an active proliferative process, where interstitial cells of the valve transform into either myofibroblasts or osteoblast-like cells causing valve deformation, thickening of cusps ...
  • Vertebral Bone Mineral Density Measured by Quantitative Computed Tomography With and Without a Calibration Phantom: A Comparison Between 2 Different Software Solutions 

    Therkildsen, Josephine; Thygesen, Jesper; Winther, Simon; Svensson, My Hanna Sofie; Hauge, Ellen-Margrethe; Bøttcher, Morten; Ivarsen, Per; Jørgensen, Hanne Skou (Journal of Clinical Densitometry;21(3), Journal article; Peer reviewed, 2018-03-27)
    Quantitative computed tomography (CT) can be used to quantify bone mineral density (BMD) in the spine from clinical CT scans. We aimed to determine agreement and precision of BMD measurements by 2 different methods: ...
  • Assay of steroids by liquid chromatography-tandem mass spectrometry in monitoring 21-hydroxylase deficiency 

    Dahl, Sandra Rine; Nermoen, Ingrid; Brønstad, Ingeborg; Husebye, Eystein Sverre; Løvås, Kristian; Thorsby, Per Medbøe (Endocrine connections;7(12), Journal article; Peer reviewed, 2018-12)
    Immunoassays of steroid hormones are still used in the diagnosis and monitoring of patients with congenital adrenal hyperplasia. However, cross-reactivity between steroids can give rise to falsely elevated steroid levels. ...
  • Activated prothrombin complex concentrate to reverse the factor Xa inhibitor (apixaban) effect before emergency surgery: A case series 

    Schultz, Nina Haagenrud; Lundblad, Runar; Holme, Pål Andre (Journal of Medical Case Reports;12(1), Journal article; Peer reviewed, 2018-05-16)
    Background The lack of an antidote against factor Xa inhibitors in case of major bleeding or need for urgent surgery is a concern to clinicians. Guidelines on managing major bleeding in patients under anticoagulation with ...

View more