dc.contributor.author | Skogvold, Hanne Bendiksen | |
dc.contributor.author | Rootwelt, Helge | |
dc.contributor.author | Reubsaet, Leon | |
dc.contributor.author | Elgstøen, Katja B. Prestø | |
dc.contributor.author | Wilson, Steven Ray Haakon | |
dc.date.accessioned | 2023-10-31T06:45:28Z | |
dc.date.available | 2023-10-31T06:45:28Z | |
dc.date.created | 2023-06-23T11:39:15Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Journal of Separation Science. 2023, 46 (15), . | en_US |
dc.identifier.issn | 1615-9306 | |
dc.identifier.uri | https://hdl.handle.net/11250/3099548 | |
dc.description.abstract | Dried blood spot samples are simple to prepare and transport, enabling safe andaccessible diagnostics, both locally and globally. We review dried blood spot sam-ples for clinical analysis, focusing on liquid chromatography-mass spectrometryas a versatile measurement tool for these samples. Dried blood spot samplescan provide information for, for example, metabolomics, xenobiotic analysis,and proteomics. Targeted analyses of small molecules are the main applica-tion of dried blood spot samples and liquid chromatography-mass spectrometry,but emerging applications include untargeted metabolomics and proteomics.Applications are highly varied, including analyses related to newborn screen-ing, diagnostics and monitoring of disease progression and treatment effects ofvirtually any disease, as well as studies into the physiology and effects of diet,exercise, xenobiotics, and doping. A range of dried blood spot products andmethods are available, and applied liquid chromatography-mass spectrometryinstrumentation is varied with regard to liquid chromatography column formatsand selectivity. In addition, novel approaches such as on-paper sample prepara-tion (e.g., selective trapping of analytes with paper-immobilized antibodies) aredescribed. We focus on research papers published in the last 5 years. | en_US |
dc.language.iso | eng | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Dried blood spot analysis with liquid chromatography and mass spectrometry: Trends in clinical chemistry | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.doi | 10.1002/jssc.202300210 | |
dc.identifier.cristin | 2157415 | |
dc.source.journal | Journal of Separation Science | en_US |
dc.source.volume | 46 | en_US |
dc.source.issue | 15 | en_US |
dc.source.pagenumber | 15 | en_US |