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dc.contributor.authorMathew, Anna
dc.contributor.authorHassan, Hafiz Wajahat
dc.contributor.authorKorostynska, Olga
dc.contributor.authorWestad, Frank
dc.contributor.authorMota-Silva, Eduarda
dc.contributor.authorMenichetti, Luca
dc.contributor.authorMirtaheri, Peyman
dc.date.accessioned2023-09-12T10:33:32Z
dc.date.available2023-09-12T10:33:32Z
dc.date.created2023-04-12T10:51:00Z
dc.date.issued2023
dc.identifier.citationSensors. 2023, 23 (6), .en_US
dc.identifier.issn1424-8220
dc.identifier.urihttps://hdl.handle.net/11250/3088844
dc.description.abstractBiodegradable magnesium-based implants offer mechanical properties similar to natural bone, making them advantageous over nonbiodegradable metallic implants. However, monitoring the interaction between magnesium and tissue over time without interference is difficult. A noninvasive method, optical near-infrared spectroscopy, can be used to monitor tissue’s functional and structural properties. In this paper, we collected optical data from an in vitro cell culture medium and in vivo studies using a specialized optical probe. Spectroscopic data were acquired over two weeks to study the combined effect of biodegradable Mg-based implant disks on the cell culture medium in vivo. Principal component analysis (PCA) was used for data analysis. In the in vivo study, we evaluated the feasibility of using the near-infrared (NIR) spectra to understand physiological events in response to magnesium alloy implantation at specific time points (Day 0, 3, 7, and 14) after surgery. Our results show that the optical probe can detect variations in vivo from biological tissues of rats with biodegradable magnesium alloy “WE43” implants, and the analysis identified a trend in the optical data over two weeks. The primary challenge of in vivo data analysis is the complexity of the implant interaction near the interface with the biological medium.en_US
dc.language.isoengen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleIn Vivo Analysis of a Biodegradable Magnesium Alloy Implant in an Animal Model Using Near-Infrared Spectroscopyen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doi10.3390/s23063063
dc.identifier.cristin2140215
dc.source.journalSensorsen_US
dc.source.volume23en_US
dc.source.issue6en_US
dc.source.pagenumber0en_US


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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal