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dc.contributor.authorHassan, Hafiz Wajahat
dc.contributor.authorMota-Silva, Eduardo
dc.contributor.authorGrasso, Valeria
dc.contributor.authorRiehakainen, Leon
dc.contributor.authorJose, Jithin
dc.contributor.authorMenichetti, Luca
dc.contributor.authorMirtaheri, Peyman
dc.date.accessioned2023-05-09T13:47:09Z
dc.date.available2023-05-09T13:47:09Z
dc.date.created2023-02-28T12:25:45Z
dc.date.issued2023
dc.identifier.citationSensors. 2023, 23 2297-?.en_US
dc.identifier.issn1424-8220
dc.identifier.urihttps://hdl.handle.net/11250/3067350
dc.description.abstractMagnesium (Mg) alloys possess unique properties that make them ideal for use as biodegradable implants in clinical applications. However, reports on the in vivo assessment of these alloys are insufficient. Thus, monitoring the degradation of Mg and its alloys in vivo is challenging due to the dynamic process of implant degradation and tissue regeneration. Most current works focus on structural remodeling, but functional assessment is crucial in providing information about physiological changes in tissues, which can be used as an early indicator of healing. Here, we report continuous wave near-infrared spectroscopy (CW NIRS), a non-invasive technique that is potentially helpful in assessing the implant–tissue dynamic interface in a rodent model. The purpose of this study was to investigate the effects on hemoglobin changes and tissue oxygen saturation (StO2) after the implantation of Mg-alloy (WE43) and titanium (Ti) implants in rats’ femurs using a multiwavelength optical probe. Additionally, the effect of changes in the skin on these parameters was evaluated. Lastly, combining NIRS with photoacoustic (PA) imaging provides a more reliable assessment of tissue parameters, which is further correlated with principal component analysis.en_US
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.ispartofseriesSensors;
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleNear-Infrared Spectroscopy for the In Vivo Monitoring of Biodegradable Implants in Ratsen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.source.articlenumber2297en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doihttps://doi.org/10.3390/s23042297
dc.identifier.cristin2130054
dc.source.journalSensorsen_US
dc.source.volume23en_US


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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal