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dc.contributor.authorEvensen, Helge
dc.contributor.authorSmåstuen, Milada Cvancarova
dc.contributor.authorSchulz, Anselm
dc.contributor.authorKristensen, Vendel Ailin
dc.contributor.authorLarssen, Lene
dc.contributor.authorSkattum, Jorunn Pettersen
dc.contributor.authorSandstad, Olav
dc.contributor.authorHauge, Truls
dc.contributor.authorMedhus, Asle Wilhelm
dc.date.accessioned2022-04-05T09:16:36Z
dc.date.available2022-04-05T09:16:36Z
dc.date.created2021-12-02T14:47:44Z
dc.date.issued2021
dc.identifier.citationAnnals of Medicine. 2021, 53 (1), 2227-2235.en_US
dc.identifier.issn0785-3890
dc.identifier.urihttps://hdl.handle.net/11250/2989859
dc.description.abstractPeroral endoscopic myotomy (POEM) is an established therapy for achalasia, but outcome evaluation has often been limited to Eckardt score (ES). The present study was aimed to improve knowledge about outcome evaluation and predictive outcome factors by performing a comprehensive objective evaluation of achalasia patients treated by POEM. Methods: This single centre prospective study reports outcome data 12 months after POEM in treatment-naive achalasia patients. A predefined follow-up protocol included ES, high resolution manometry, 24-h pH measurement, upper endoscopy and timed barium esophagogram (TBE). Univariate and multivariate regression analyses were performed to analyze association between post-POEM variables and identify predictive factors for objective outcome. Results: Fifty patients were included with a drop-out rate of < .001), and 28% (13/47) of the patients had a positive 24-h pH registration. An oesophageal diameter >3 cm after POEM was associated with treatment failure assessed by ES (p ¼ .04) and TBE (p ¼ .03). Advanced achalasia stage (p ¼ .02) and long symptom duration (p ¼ .04) were identified as independent predictive factors for poor outcome assessed by TBE. Conclusions: The present study confirms that POEM is an efficient therapy for achalasia. The comprehensive objective evaluation after POEM demonstrates that long symptom duration and major changes in oesophageal anatomy at diagnosis imply poor treatment outcome, and a post-POEM dilated oesophagus is associated with treatment failure.en_US
dc.language.isoengen_US
dc.publisherTaylor & Francis Open Accessen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.subjectAchalasiaen_US
dc.subjectGastroesophageal reflux diseaseen_US
dc.subjectPeroral endoscopic myotomyen_US
dc.subjectEvaluationen_US
dc.titleOne year comprehensive prospective follow-up of achalasia patients after peroral endoscopic myotomyen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doi10.1080/07853890.2021.2005253
dc.identifier.cristin1963547
dc.source.journalAnnals of Medicineen_US
dc.source.volume53en_US
dc.source.issue1en_US
dc.source.pagenumber2227-2235en_US


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