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dc.contributor.authorLarsen, Sunniva Veen
dc.contributor.authorHolven, Kirsten B.
dc.contributor.authorChristensen, Jacob J.
dc.contributor.authorFlatberg, Arnar
dc.contributor.authorRundblad, Amanda
dc.contributor.authorLeder, Lena
dc.contributor.authorBlomhoff, Rune
dc.contributor.authorTelle-Hansen, Vibeke
dc.contributor.authorKolehmainen, Marjukka
dc.contributor.authorCarlberg, Carsten
dc.contributor.authorMyhrstad, Mari C.
dc.contributor.authorThoresen, Magne
dc.contributor.authorUlven, Stine M.
dc.identifier.citationMolecular Nutrition & Food Research. 2021, 65 (24), .en_US
dc.description.abstractScope The aim of this study is to explore the molecular mechanisms underlying the effect of replacing dietary saturated fat (SFA) with polyunsaturated fat (PUFA) on cardiovascular disease (CVD) risk using a whole transcriptome approach. Methods and Results Healthy subjects with moderate hypercholesterolemia (n = 115) are randomly assigned to a control diet (C-diet) group or an experimental diet (Ex-diet) group receiving comparable food items with different fatty acid composition for 8 weeks. RNA isolated from peripheral blood mononuclear cells (PBMCs) at baseline and after 8 weeks of intervention is analyzed by microarray technology (n = 95). By use of a linear regression model (n = 92), 14 gene transcripts are differentially altered in the Ex-diet group compared to the C-diet group. These include transcripts related to vascular smooth muscle cell proliferation, low-density lipoprotein receptor folding, and regulation of blood pressure. Furthermore, pathways mainly related to immune response and inflammation, signal transduction, development, and cytoskeleton remodeling, gene expression and protein function, are differentially enriched between the groups. Conclusion Replacing dietary SFA with PUFA for 8 weeks modulates PBMC gene expression and pathways related to CVD risk in healthy subjects with moderate hypercholesterolemia.en_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleReplacing saturated fat with polyunsaturated fat modulates peripheral blood mononuclear cell gene expression and pathways related to cardiovascular disease risk using a whole transcriptome approachen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.source.journalMolecular Nutrition & Food Researchen_US
dc.relation.projectUniversity of Osloen_US
dc.relation.projectThrone Holst Nutrition Research Foundationen_US
dc.subject.nsiVDP::Medisinske Fag: 700::Helsefag: 800::Ernæring: 811en_US

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