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dc.contributor.authorFragoso-Bargas, Nicolas
dc.contributor.authorOpsahl, Julia Onsrud
dc.contributor.authorKiryushchenko, Nadezhda
dc.contributor.authorBöttcher, Yvonne
dc.contributor.authorLee-Ødegård, Sindre
dc.contributor.authorQvigstad, Elisabeth
dc.contributor.authorRichardsen, Kåre Rønn
dc.contributor.authorWaage, Christin
dc.contributor.authorSletner, Line
dc.contributor.authorJenum, Anne Karen
dc.contributor.authorPrasad, Rashmi B.
dc.contributor.authorGroop, Leif C.
dc.contributor.authorMoen, Gunn-Helen Øiseth
dc.contributor.authorBirkeland, Kåre Inge
dc.contributor.authorSommer, Christine
dc.identifier.citationPLOS ONE. 2021, 16 (8), .en_US
dc.description.abstractPregnancy is a valuable model to study the association between DNA methylation and several cardiometabolic traits, due to its direct potential to influence mother’s and child’s health. Epigenetics in Pregnancy (EPIPREG) is a population-based sample with the aim to study associations between DNA-methylation in pregnancy and cardiometabolic traits in South Asian and European pregnant women and their offspring. This cohort profile paper aims to present our sample with genetic and epigenetic data and invite researchers with similar cohorts to collaborative projects, such as replication of ours or their results and meta-analysis. In EPIPREG we have quantified epigenome-wide DNA methylation in maternal peripheral blood leukocytes in gestational week 28±1 in Europeans (n = 312) and South Asians (n = 168) that participated in the population-based cohort STORK Groruddalen, in Norway. DNA methylation was measured with Infinium MethylationEPIC BeadChip (850k sites), with technical validation of four CpG sites using bisulphite pyrosequencing in a subset (n = 30). The sample is well characterized with few missing data on e.g. genotype, universal screening for gestational diabetes, objectively measured physical activity, bioelectrical impedance, anthropometrics, biochemical measurements, and a biobank with maternal serum and plasma, urine, placenta tissue. In the offspring, we have repeated ultrasounds during pregnancy, cord blood, and anthropometrics up to 4 years of age. We have quantified DNA methylation in peripheral blood leukocytes in nearly all eligible women from the STORK Groruddalen study, to minimize the risk of selection bias. Genetic principal components distinctly separated Europeans and South Asian women, which fully corresponded with the self-reported ethnicity. Technical validation of 4 CpG sites from the methylation bead chip showed good agreement with bisulfite pyrosequencing. We plan to study associations between DNA methylation and cardiometabolic traits and outcomes.en_US
dc.publisherPublic Library of Scienceen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleCohort profile: Epigenetics in pregnancy (EPIPREG) – population-based sample of European and South Asian pregnant women with epigenome-wide DNA methylation (850k) in peripheral blood leukocytesen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.source.journalPLOS ONEen_US
dc.relation.projectNorges forskningsråd: 287198en_US
dc.relation.projectHelse Sør-Øst HF: 2019092en_US
dc.subject.nsiVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Gynekologi og obstetrikk: 756en_US

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Navngivelse 4.0 Internasjonal
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