dc.contributor.author | Kosanovic, Maja | |
dc.contributor.author | Llorente, Alicia | |
dc.contributor.author | Glamočlija, Sofija | |
dc.contributor.author | Valdivielso, Jose M. | |
dc.contributor.author | Bozic, Milica | |
dc.date.accessioned | 2021-12-21T16:51:46Z | |
dc.date.available | 2021-12-21T16:51:46Z | |
dc.date.created | 2021-05-06T12:41:41Z | |
dc.date.issued | 2021-04-09 | |
dc.identifier.citation | International Journal of Molecular Sciences. 2021, 22:3887 (8), 1-19. | en_US |
dc.identifier.issn | 1422-0067 | |
dc.identifier.issn | 1661-6596 | |
dc.identifier.uri | https://hdl.handle.net/11250/2835290 | |
dc.description.abstract | Renal fibrosis is a complex disorder characterized by the destruction of kidney parenchyma. There is currently no cure for this devastating condition. Extracellular vesicles (EVs) are membranous vesicles released from cells in both physiological and diseased states. Given their fundamental role in transferring biomolecules to recipient cells and their ability to cross biological barriers, EVs have been widely investigated as potential cell-free therapeutic agents. In this review, we provide an overview of EVs, focusing on their functional role in renal fibrosis and signaling messengers responsible for EV-mediated crosstalk between various renal compartments. We explore recent findings regarding the renoprotective effect of EVs and their use as therapeutic agents in renal fibrosis. We also highlight advantages and future perspectives of the therapeutic applications of EVs in renal diseases. | en_US |
dc.description.sponsorship | This research was supported by Miguel Servet research grant CP19/00027 from the Instituto de Salud Carlos III (ISCIII) and FEDER funds “Una manera de hacer Europa”. M.B. was supported by the Miguel Servet contract from the ISCIII (CP19/00027) financed by Fondo Social Europeo ‘’El FSE invierte en tu futuro”. M.K. and S.G. were supported by the research grant from the Ministry of Education, Science, and Technological Development of the Republic of Serbia (Contract No. 451-03-9/2021-14/200019). A.L. was funded by The Southeastern Norwegian Regional Health Authority. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | MDPI | en_US |
dc.relation.ispartofseries | International Journal of Molecular Sciences;Volume 22, Issue 8 | |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.subject | Extracellular vesicles | en_US |
dc.subject | Exosomes | en_US |
dc.subject | Cellular communication | en_US |
dc.subject | Renal fibrosis | en_US |
dc.subject | Chronic kidney disease | en_US |
dc.subject | Therapeutic agents | en_US |
dc.subject | Regeneration | en_US |
dc.title | Extracellular vesicles and renal fibrosis: An odyssey toward a new therapeutic approach | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | © 2021 by the authors. | en_US |
dc.source.articlenumber | 3887 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.doi | https://doi.org/10.3390/ijms22083887 | |
dc.identifier.cristin | 1908462 | |
dc.source.journal | International Journal of Molecular Sciences | en_US |
dc.source.volume | 22 | en_US |
dc.source.issue | 8 | en_US |
dc.source.pagenumber | 1-19 | en_US |