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dc.contributor.authorKosanovic, Maja
dc.contributor.authorLlorente, Alicia
dc.contributor.authorGlamočlija, Sofija
dc.contributor.authorValdivielso, Jose M.
dc.contributor.authorBozic, Milica
dc.date.accessioned2021-12-21T16:51:46Z
dc.date.available2021-12-21T16:51:46Z
dc.date.created2021-05-06T12:41:41Z
dc.date.issued2021-04-09
dc.identifier.citationInternational Journal of Molecular Sciences. 2021, 22:3887 (8), 1-19.en_US
dc.identifier.issn1422-0067
dc.identifier.issn1661-6596
dc.identifier.urihttps://hdl.handle.net/11250/2835290
dc.description.abstractRenal fibrosis is a complex disorder characterized by the destruction of kidney parenchyma. There is currently no cure for this devastating condition. Extracellular vesicles (EVs) are membranous vesicles released from cells in both physiological and diseased states. Given their fundamental role in transferring biomolecules to recipient cells and their ability to cross biological barriers, EVs have been widely investigated as potential cell-free therapeutic agents. In this review, we provide an overview of EVs, focusing on their functional role in renal fibrosis and signaling messengers responsible for EV-mediated crosstalk between various renal compartments. We explore recent findings regarding the renoprotective effect of EVs and their use as therapeutic agents in renal fibrosis. We also highlight advantages and future perspectives of the therapeutic applications of EVs in renal diseases.en_US
dc.description.sponsorshipThis research was supported by Miguel Servet research grant CP19/00027 from the Instituto de Salud Carlos III (ISCIII) and FEDER funds “Una manera de hacer Europa”. M.B. was supported by the Miguel Servet contract from the ISCIII (CP19/00027) financed by Fondo Social Europeo ‘’El FSE invierte en tu futuro”. M.K. and S.G. were supported by the research grant from the Ministry of Education, Science, and Technological Development of the Republic of Serbia (Contract No. 451-03-9/2021-14/200019). A.L. was funded by The Southeastern Norwegian Regional Health Authority.en_US
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.ispartofseriesInternational Journal of Molecular Sciences;Volume 22, Issue 8
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.subjectExtracellular vesiclesen_US
dc.subjectExosomesen_US
dc.subjectCellular communicationen_US
dc.subjectRenal fibrosisen_US
dc.subjectChronic kidney diseaseen_US
dc.subjectTherapeutic agentsen_US
dc.subjectRegenerationen_US
dc.titleExtracellular vesicles and renal fibrosis: An odyssey toward a new therapeutic approachen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.rights.holder© 2021 by the authors.en_US
dc.source.articlenumber3887en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doihttps://doi.org/10.3390/ijms22083887
dc.identifier.cristin1908462
dc.source.journalInternational Journal of Molecular Sciencesen_US
dc.source.volume22en_US
dc.source.issue8en_US
dc.source.pagenumber1-19en_US


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