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dc.contributor.authorBø, Ragnhild
dc.contributor.authorKraft, Brage
dc.contributor.authorJonassen, Rune
dc.contributor.authorHarmer, Catherine
dc.contributor.authorHilland, Eva
dc.contributor.authorStiles, Tore C
dc.contributor.authorHaaland, Vegard Øksendal
dc.contributor.authorAspesletten, Maria E.B.
dc.contributor.authorSletvold, Hanna
dc.contributor.authorLandrø, Nils Inge
dc.date.accessioned2021-06-23T14:09:32Z
dc.date.available2021-06-23T14:09:32Z
dc.date.created2021-06-21T21:37:37Z
dc.date.issued2021-05-05
dc.identifier.citationJournal of Psychiatric Research. 2021, 138, (528-534).en_US
dc.identifier.issn0022-3956
dc.identifier.urihttps://hdl.handle.net/11250/2760939
dc.description.abstractA recent meta-analysis has questioned the relevance of attention bias modification (ABM) for depression out- comes. However, there might be patient characteristics not yet accounted for, that are relevant to the outcome. In the context of personalized treatment, the lack of moderator studies have limited the potential for matching ABM-treatment to individual patient characteristics. Subjects (N = 301) were randomly assigned 1:1 to receive either active or placebo Attention Bias Modification (ABM) twice daily for 14 days in a double-blind design (placebo n = 148; ABM n = 153). The outcome was change in symptoms based on the Hamilton Depression Rating Scale (HDRS). Moderator variables were self-reported depression (Beck Depression Inventory-II; BDI-II), anxiety (Beck Anxiety Inventory; BAI) and attentional bias (AB) assessed at baseline. This trial was registered with ClinicalTrials.gov, number NCT02658682. Only BAI (p for interaction = .01, Bootstrap 95% CI [0.046, 0.337]) moderated the effects of ABM on change in clinician rated depressive symptoms. Interactions were significant for BAI scores ≥8. The relative effect of the intervention increased with the highest symptom load. ABM was not effective in patients with the lowest symptom load. Future research should validate this finding and continue investigating moderators of the ABM-intervention to further enhance personalization of treatment to individual symptom characteristics.en_US
dc.description.sponsorshipThe Department of Psychology, University of Oslo has also supported the project.en_US
dc.language.isoengen_US
dc.publisherElseveiren_US
dc.relation.ispartofseriesJournal of Psychiatric Research;volume 138
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.subjectAttention bias modificationsen_US
dc.subjectModeratorsen_US
dc.subjectDepressionsen_US
dc.subjectAnxietyen_US
dc.subjectAttentional biasen_US
dc.titleSymptom Severity Moderates the Outcome of Attention Bias Modification for Depression: an Exploratory Study.en_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.rights.holder© 2021 The Author(s).en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doihttps://doi.org/10.1016/j.jpsychires.2021.04.027
dc.identifier.cristin1917531
dc.source.journalJournal of Psychiatric Researchen_US
dc.source.volume138en_US
dc.source.pagenumber7en_US
dc.relation.projectResearch Council of Norway: 229135.en_US
dc.relation.projectThe South East Norway Health Authority Research Funding: 2015052en_US


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