dc.contributor.author | Bråten, Lars Christian Haugli | |
dc.contributor.author | Schistad, Ellina Iordanova | |
dc.contributor.author | Espeland, Ansgar | |
dc.contributor.author | Kristoffersen, Per M | |
dc.contributor.author | Haugen, Anne Julsrud | |
dc.contributor.author | Marchand, Gunn Hege | |
dc.contributor.author | Vetti, Nils | |
dc.contributor.author | Pripp, Are Hugo | |
dc.contributor.author | Kadar, Thomas | |
dc.contributor.author | Skouen, Jan Sture | |
dc.contributor.author | Grotle, Margreth | |
dc.contributor.author | Grøvle, Lars | |
dc.contributor.author | Zwart, John-Anker | |
dc.contributor.author | Brox, Jens Ivar | |
dc.contributor.author | Storheim, Kjersti | |
dc.coverage.spatial | Norway | en_US |
dc.date.accessioned | 2021-05-10T07:41:01Z | |
dc.date.available | 2021-05-10T07:41:01Z | |
dc.date.created | 2021-01-12T13:13:19Z | |
dc.date.issued | 2020-06-10 | |
dc.identifier.citation | BMC Musculoskeletal Disorders. 2020, 21 . | en_US |
dc.identifier.issn | 1471-2474 | |
dc.identifier.uri | https://hdl.handle.net/11250/2754493 | |
dc.description.abstract | Background: Modic Changes (MCs, magnetic resonance imaging (MRI) signal changes in the vertebral bone marrow extending from the vertebral endplate) may represent a subgroup of nonspecific chronic low back pain that could benefit from a specific management. The primary aim was to compare clinical characteristics between patients with type 1 versus type 2 MCs. The secondary aim was to explore associations between clinical characteristics and MC related short tau inversion recovery (STIR) signals. Methods: This cross-sectional study used baseline data prospectively collected between 2015 and 2017 on the 180 patients included in the AIM-study (Antibiotics In Modic changes), a randomized controlled trial in a Norwegian hospital out-patient setting of patients with chronic low back pain, a lumbar disc herniation within the last 2 years, low back pain intensity score ≥ 5 (on a 0–10 scale) and current type 1 or type 2 MCs at the previously herniated lumbar disc level. We used prespecified clinical characteristics including self-report measures, physiologic measures and functional measures from clinical history and examination. The diagnostic accuracy of various clinical characteristics to discriminate between patients with type 1 MCs (with or without additional type 2 MCs) and patents with type 2 MCs only (not type 1) were assessed by calculating the area under the receiver-operating curve. We assessed the correlations of clinical characteristics with details of MC related STIR signal increase. Results: No clinical characteristic differed between patients with type 1 (n = 118) versus type 2 (but not type 1) (n = 62) MCs. The clinical characteristics showed no/minor differences or no/weak correlations with MC related STIR signal increase. Patients with a positive Springing test (at any lumbar level) had slightly less volume of STIR signal increase than those with a negative test (mean difference 1.3 on a 0–48 scale, 95% CI 0.3 to 2.3). Conclusion: Clinical characteristics were similar for patients with type 1 MCs and patients with type 2 MCs, and showed no clinically relevant correlations with MC related STIR signal increase. | en_US |
dc.description.sponsorship | The trial was funded by governmental organisations; Helse Sør-Øst (grant no: 2015090) and Helse Vest (grant no: 911938 and 911891). | en_US |
dc.language.iso | eng | en_US |
dc.publisher | BMC | en_US |
dc.relation.ispartofseries | BMC Musculoskeletal Disorders;21, Article number: 368 (2020) | |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.subject | Modic changes | en_US |
dc.subject | Low back pain | en_US |
dc.subject | Clinical characteristics | en_US |
dc.subject | Diagnostic accuracy | en_US |
dc.subject | Short tau inversion recoveries | en_US |
dc.subject | Bone marrow edema | en_US |
dc.subject | Magnetic resonance images | en_US |
dc.title | Association of Modic change types and their short tau inversion recovery signals with clinical characteristics : a cross sectional study of chronic low back pain patients in the AIM-study | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | © The Author(s). | en_US |
dc.source.articlenumber | 368 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.doi | https://doi.org/10.1186/s12891-020-03381-4 | |
dc.identifier.cristin | 1869821 | |
dc.source.journal | BMC Musculoskeletal Disorders | en_US |
dc.source.volume | 21 | en_US |
dc.source.pagenumber | 10 | en_US |