Browsing TKD - Institutt for informasjonsteknologi by Author "van de Wijdeven, Rosanne Francisca"

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Micro-and mesoscale aspects of neurodegeneration in engineered human neural networks carrying the LRRK2 G2019S mutation

Valderhaug, Vibeke Devold; Ramstad, Ola Huse; van de Wijdeven, Rosanne Francisca; Heiney, Kristine; Nichele, Stefano; Sandvig, Axel; Sandvig, Ioanna (Peer reviewed; Journal article, 2024)

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been widely linked to Parkinson’s disease, where the G2019S variant has been shown to contribute uniquely to both familial and sporadic forms of the disease. ...
Structural and functional alterations associated with the LRRK2 G2019S mutation revealed in structured human neural networks

Valderhaug, Vibeke Devold; Huse Ramstad, Ola; van de Wijdeven, Rosanne Francisca; Heiney, Kristine; Nichele, Stefano; Sandvig, Axel; Sandvig, Ioanna (bioRxiv;, Journal article, 2020-05-02)

Mutations in the LRRK2 gene have been widely linked to Parkinson ́s disease. The G2019S variant has been shown to contribute uniquely to both familial and sporadic forms of the disease. LRRK2-related mutations have been ...