• Correlation of body weight and composition with hepatic activities of cytochrome P450 enzymes 

      Krogstad, Veronica; Peric, Alexandra; Robertsen, Ida; Kringen, Marianne K.; Vistnes, Maria; Hjelmesæth, Jøran; Sandbu, Rune; Johnson, Line Kristin; Angeles, Philip Carlo Soriano; Jansson-Löfmark, Rasmus; Karlsson, Cecilia; Andersson, Shalini; Åsberg, Anders; Andersson, Tommy B.; Christensen, Hege Staaland (Journal of Pharmaceutical Sciences;Volume 110, Issue 1, Journal article; Peer reviewed, 2020-10-18)
      Obesity is associated with comorbidities of which pharmacological treatment is needed. Physiological changes associated with obesity may influence the pharmacokinetics of drugs, but the effect of body weight on drug ...
    • Correlations between 4β-hydroxycholesterol and hepatic and intestinal CYP3A4: protein expression, microsomal ex vivo activity, and in vivo activity in patients with a wide body weight range 

      Kvitne, Kine Eide; Hole, Kristine; Krogstad, Veronica; Wollmann, Birgit Malene Tovik; Wegler, Christine; Johnson, Line Kristin; Hertel, Jens Kristoffer; Artursson, Per; Karlsson, Cecilia; Andersson, Shalini; Andersson, Tommy B.; Sandbu, Rune; Hjelmesæth, Jøran Sture; Skovlund, Eva; Christensen, Hege; Jansson-Löfmark, Rasmus; Åsberg, Anders; Molden, Espen; Robertsen, Ida (European Journal of Clinical Pharmacology;Volume 78, issue 8, Peer reviewed; Journal article, 2022-06-01)
      Purpose Variability in cytochrome P450 3A4 (CYP3A4) metabolism is mainly caused by non-genetic factors, hence providing a need for accurate phenotype biomarkers. Although 4β-hydroxycholesterol (4βOHC) is a promising ...
    • Myotubes from Severely Obese Type 2 Diabetic Subjects Accumulate Less Lipids and Show Higher Lipolytic Rate than Myotubes from Severely Obese Non-Diabetic Subjects 

      Bakke, Siril Skaret; Feng, Yuan Zeng; Nikolic, Natasa; Kase, Eili Tranheim; Moro, Cedric; Stensrud, Camilla; Damlien, Lisbeth; Ludahl, Marianne Odnakk; Sandbu, Rune; Solheim, Brita Marie; Rustan, Arild; Hjelmesæth, Jøran; Thoresen, G. Hege; Aas, Vigdis (Journal article; Peer reviewed, 2015-03-19)
      About 80% of patients with type 2 diabetes are classified as overweight. However, only about 1/3 of severely obese subjects have type 2 diabetes. This indicates that several se- verely obese individuals may possess certain ...
    • Short- and long-term effects of body weight, calorie restriction and gastric bypass on CYP1A2, CYP2C19 and CYP2C9 activity 

      Kvitne, Kine Eide; Krogstad, Veronica; Wegler, Christine; Johnson, Line Kristin; Kringen, Marianne K.; Hovd, Markus Herberg; Hertel, Jens Kristoffer; Heijer, Maria; Sandbu, Rune; Skovlund, Eva; Artursson, Per; Karlsson, Cecilia; Andersson, Shalini; Andersson, Tommy B.; Hjelmesæth, Jøran Sture; Åsberg, Anders; Jansson-Löfmark, Rasmus; Christensen, Hege; Robertsen, Ida (British Journal of Clinical Pharmacology;Volume 88, Issue 9, Peer reviewed; Journal article, 2022-04-11)
      Aim: Roux-en-Y gastric bypass (RYGB) may influence drug disposition due to surgery-induced gastrointestinal alterations and/or subsequent weight loss. The objective was to compare short- and long-term effects of RYGB and ...