Mammographic breast density over time among women who have participated in BreastScreen Norway
Journal article, Peer reviewed
Accepted version
Date
2018-07-06Metadata
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Original version
Moshina N, Waade GG, Roman M, Sebuødegård S, Hofvind S. Mammographic breast density over time among women who have participated in BreastScreen Norway. Progress in Biomedical Optics and Imaging. 2018;10718 http://dx.doi.org/10.1117/12.2317927Abstract
Background:
We analyzed the consistency in absolute and percent density using an automated method for estimating volumetric breast
density among women who attended BreastScreen Norway 2007-2015.
Material and Methods:
We used information from 33,711 women aged 50-69 who underwent two to five full field digital screening
examinations biennially, 2007-2015. BMI and HT-use was obtained from a self-administered questionnaire, sent together
with the invitation to screening. BMI was categorized into <21.0; 21.0-24.9; ≥25.0 kg/m2, while use of HT was defined
as ever versus never used. An automated method estimated fibroglandular volume (cm3), breast volume (cm3) and
volumetric breast density (%) for each screening examination. We applied mixed-effects linear models to estimate
associations between age, fibroglandular volume, breast volume and volumetric breast density over time including data
on BMI and HT.
Results:
The results models indicated age to be associated with decreased fibroglandular volume and volumetric breast density,
and increased breast volume. BMI <21 kg/m2 was associated with higher volumetric breast density, but lower
fibroglandular and breast volume. Contrary, BMI ≥25 kg/m2 was associated with lower volumetric breast density and
higher fibroglandular and breast volumes. Variation in volumetric breast density and fibroglandular volume within
women was rather subtle: this variance did not exceed 10% for either volumetric breast density, fibroglandular volume or
breast volume.
Conclusion:
Automated measures of volumetric breast density and fibroglandular volume software decreased with age among women
screened in BreastScreen Norway. Absolute and percent density varied with a maximum of 10% over time, from first to
last screening examination.