• Antiepileptic and antidepressive polypharmacy in patients with multiple sclerosis. 

      Beiske, Georg; Holmøy, Trygve; Beiske, Antonie Giæver; Johannessen, Svein Ivar; Landmark, Cecilie Johannessen (Multiple sclerosis international;2015, Journal article; Peer reviewed, 2015)
      Objective. Patients with multiple sclerosis (MS) are often suffering from neuropathic pain. Antiepileptic drugs (AEDs) and tricyclic antidepressants (TCAs) are commonly used and are susceptible to be involved in drug ...
    • Best mulig behandling med antiepileptika for den enkelte pasient! 

      Landmark, Cecilie Johannessen; Baftiu, Arton; Burns, Margrete Larsen; Mevåg, Morten A; Feet, Silje Andrea; Reiter, Lillian; Johannessen, Svein Ivar (Norsk Farmaceutisk Tidsskrift;(2), Journal article; Peer reviewed, 2015)
      Hensikt «Best mulig behandling med antiepileptika for den enkelte pasient!» er et avgjørende mål for behandling av pasienter med epilepsi, men også for stadig nye pasientgrupper som bruker antiepileptika. Hensikten med ...
    • Challenges in epilepsy – the perspective of Norwegian epilepsy patients 

      Henning, Oliver Johannes; Landmark, Cecilie Johannessen; henning, david; Nakken, Karl Otto; Lossius, Morten (Acta Neurologica Scandinavica;Volume 140, Issue 1, July 2019, Journal article; Peer reviewed, 2019-04-08)
      Objectives: For most people with epilepsy (PWE), problems that are not directly related to seizures may constitute major challenges in everyday life. The purpose of this study was to determine the extent of these challenges ...
    • Clinical experience combined with therapeutic drug monitoringof lacosamide 

      Svendsen, Torleiv; Brodtkorb, Eylert; Baftiu, Arton; Lossius, Morten; Nakken, Karl Otto; Johannessen, Svein Ivar; Landmark, Cecilie Johannessen (Acta Neurologica Scandinavica;Volume 141, Issue 4, Journal article; Peer reviewed, 2019-12-14)
      Objective: Lacosamide (LCM) is an antiepileptic drug (AED) with insufficient clinical experience in patients with intellectual disability (ID). They often have more severe epilepsy with comorbidities. The objective was to ...
    • Drug interactions involving the new second- and third-generation antiepileptic drugs 

      Landmark, Cecilie Johannessen; Patsalos, Philip N. (Expert Review of Neurotherapeutics;10 (1), Journal article; Peer reviewed, 2010-01)
      During the period 1989-2009, 14 new antiepileptic drugs (AEDs) were licensed for clinical use and these can be subdivided into new second- and third-generation AEDs. The second-generation AEDs comprise felbamate, gabapentin, ...
    • Epilepsy and cannabidiol: a guide to treatment 

      Arizmanoglou, Alexis; Brandl, Ulrich; Cross, Helen; Gil-nagel, Antonio; Lagae, Lieven; Landmark, Cecilie Johannessen; Specchio, Nicola; Nabbout, Rima; Thiele, Elisabeth; Gubbay, Oliver (Epileptic Disorders;Volume 22, Issue 1, February 2020, Journal article; Peer reviewed, 2020-12-19)
      The growing interest in cannabidiol (CBD), specifically a pure form of CBD, as a treatment for epilepsy, among other conditions, is reflected in recent changes in legislation in some countries. Although there has been much ...
    • Legemidler og pasientsikkerhet - fokus på eldre 

      Hagesæter, Ellen; Landmark, Cecilie Johannessen; Neslein, Inger-Lise; Granås, Anne Gerd (Journal article; Peer reviewed, 2015)
    • Long-term follow-up with therapeutic drug monitoring of antiepileptic drugs in patients with juvenile myoclonic epilepsy 

      Landmark, Cecilie Johannessen; Fløgstad, Ida; Baftiu, Arton; Syvertsen, Marte Roa; Enger, Ulla Helene; Johannessen, Svein Ivar (Epilepsy Research;Volume 155, September 2019, Journal article; Peer reviewed, 2019-05-30)
      Background and purpose: Patients with juvenile myoclonus epilepsy (JME) may experience uncontrolled seizures and challenges regarding adherence. Implementation of therapeutic drug monitoring (TDM) may contribute to ...
    • Nonadherence to treatment regimens in epilepsy from the patient's perspective and predisposing factors: Differences between intentional and unintentional lack of adherence 

      Henning, Oliver Johannes; Landmark, Cecilie Johannessen; Nakken, Karl Otto; Lossius, Morten (Epilepsia;Volume 61, Issue 2 February 2020, Journal article; Peer reviewed, 2019)
      Nonadherence to recommended antiepileptic drug (AED) treatment regimens can result in seizure relapse with increased health risks. Nonadherence can be unintentional (eg, patients forget to take a dose), or intentional, ...
    • Pharmacokinetic variability and clinical use of lacosamide in children and adolescents in Denmark and Norway 

      Burns, Margrete Larsen; Nikanorova, Marina; Baftiu, Arton; Rasmussen, Jan Borg; Johannessen, Svein Ivar; Landmark, Cecilie Johannessen (Therapeutic Drug Monitoring;41 (3): 340–347, JUNE 2019, Journal article; Peer reviewed, 2019-01-01)
      Background: The indication for the antiepileptic drug (AED) lacosamide (LCM) was recently extended to include children from the age of four. Real-life data on the use and serum concentrations of LCM in children and ...
    • Pharmacology and drug interactions of cannabinoids 

      Landmark, Cecilie Johannessen; Ulrich, Brandl (Epileptic Disorders;Vol. 22, Supplement 1, Journal article; Peer reviewed, 2020)
      Cannabinoids include a variety of substances, of which cannabidiol (CBD) is the main substance investigated for the treatment of epilepsy, and this will be the focus in the present review. CBD preparations exist in various ...
    • Reference ranges for antiepileptic drugs revisited: a practical approach to establish national guidelines 

      Reimers, Arne; Berg, Jon Andsnes; Burns, Margrete Larsen; Brodtkorb, Eylert; Johannessen, Svein Ivar; Landmark, Cecilie Johannessen (Journal article; Peer reviewed, 2018)
      Background and objective: Laboratories sometimes use different reference ranges for the same antiepileptic drug (AED), particularly for new and poorly investigated drugs. This may contribute to misunderstandings, concerns ...
    • Refractory epilepsy and nonadherence to drug treatment 

      Henning, Oliver Johannes; Lossius, Morten; Lima, Maren Haugen; Mevåg, Morten Andreas; Villagran, Antonia; Nakken, Karl Otto; Landmark, Cecilie Johannessen (Epilepsia Open;Volume 4, Issue 4,December 2019, Journal article; Peer reviewed, 2019-10-28)
      In patients with epilepsy, nonadherence to agreed antiepileptic drug (AED) treatment may result in seizure relapse, and at worst sudden unexpected death. The aim of this study was to examine the extent of both unintentional ...
    • Relationship between saliva and plasma rufinamideconcentrations in patients with epilepsy 

      Franco, Valentina; Gatti, Giuliana; Mazzuchelli, Iolanda; Landmark, Cecilie Johannessen; Perucca, Emilio (Epilepsia;Volume 61, Issue 7, July 2020, Journal article; Peer reviewed, 2020-06-20)
      The assay of saliva samples provides a valuable alternative to the use of blood samples for therapeutic drug monitoring (TDM), at least for certain categories of patients. To determine the feasibility of using saliva ...
    • A retrospective review of changes and challenges in the use ofantiseizure medicines in Dravet syndrome in Norway 

      Lund, Caroline; Burns, Margrete Larsen; Bjørnvold, Marit; Sætre, Erik; Johannessen, Svein Ivar; Landmark, Cecilie Johannessen; Heger, Katrine (Epilepsia Open;Volume 5, Issue 3, September 2020, Journal article; Peer reviewed, 2020-06-26)
      Objective: Dravet syndrome is a developmental and epileptic encephalopathy characterized by severe and drug-resistant seizures in early childhood, followed by developmental delay. The purpose of this study was to investigate ...
    • The role of new medical treatments for the management of developmental and epileptic encephalopathies: Novel concepts and results 

      Landmark, Cecilie Johannessen; Potschka, Heidrun; Auvin, Stephane; Wilmhurst, Jo M.; Johannessen, Svein; Trenite, Dorothee K. N.; Wirrell, Elaine (Epilepsia;volume 62, issue 4, Peer reviewed; Journal article, 2021-02-27)
      Developmental and epileptic encephalopathies (DEEs) are among the most chal- lenging of all epilepsies to manage, given the exceedingly frequent and often severe seizure types, pharmacoresistance to conventional antiseizure ...
    • Sexual function in people with epilepsy: Similarities and differences with the general population 

      Henning, Oliver Johannes; Landmark, Cecilie Johannessen; Træen, Bente; Svendsen, Torleiv; Farmen, Anette Huuse; Nakken, Karl Otto; Lossius, Morten (Epilepsia;Volume 60, Issue 9, September 2019, Journal article; Peer reviewed, 2019-07-17)
      Objective The potential impact of epilepsy on sexual function is important for patient welfare, but often neglected. This study explored the occurrences of different sexual problems in patients with both well‐controlled ...
    • Treatment and challenges with antiepileptic drugs in patients with juvenile myoclonic epilepsy 

      Landmark, Cecilie Johannessen; Fløgstad, Ida; Syvertsen, Marte Roa; Baftiu, Arton; Enger, Ulla Helene; Koht, Jeanette; Johannessen, Svein Ivar (Epilepsy & Behavior;Volume 98, Part A, September 2019, Journal article; Peer reviewed, 2019-07-19)
      Background: Patients with juvenile myoclonic epilepsy (JME) may have uncontrolled seizures. The purpose of this study was to investigate the use and challenges with antiepileptic drugs (AEDs) and the patients' view of ...
    • Valproat fortsatt viktig for kvinner med generalisert epilepsi 

      Alvestad, Silje; Bjørnvold, Marit; Molteberg, Ellen; Lossius, Morten; Landmark, Cecilie Johannessen (Tidsskrift for Den norske legeforening;Nr 7, Journal article; Peer reviewed, 2019-04-08)