• Antiepileptic and antidepressive polypharmacy in patients with multiple sclerosis. 

      Beiske, Georg; Holmøy, Trygve; Beiske, Antonie Giæver; Johannessen, Svein Ivar; Landmark, Cecilie Johannessen (Multiple sclerosis international;2015, Journal article; Peer reviewed, 2015)
      Objective. Patients with multiple sclerosis (MS) are often suffering from neuropathic pain. Antiepileptic drugs (AEDs) and tricyclic antidepressants (TCAs) are commonly used and are susceptible to be involved in drug ...
    • Best mulig behandling med antiepileptika for den enkelte pasient! 

      Landmark, Cecilie Johannessen; Baftiu, Arton; Burns, Margrete Larsen; Mevåg, Morten A; Feet, Silje Andrea; Reiter, Lillian; Johannessen, Svein Ivar (Norsk Farmaceutisk Tidsskrift;(2), Journal article; Peer reviewed, 2015)
      Hensikt «Best mulig behandling med antiepileptika for den enkelte pasient!» er et avgjørende mål for behandling av pasienter med epilepsi, men også for stadig nye pasientgrupper som bruker antiepileptika. Hensikten med ...
    • Bidirectionality of antiseizure and antipsychotic treatment: A population-based study 

      Revdal, Eline; Morken, Gunnar; Bakken, Inger Johanne; Bråthen, Geir; Landmark, Cecilie Johannessen; Brodtkorb, Eylert (Epilepsy & Behavior;Volume 136, November 2022, 108911, Peer reviewed; Journal article, 2022-09-17)
      Purpose: To study the prevalence and directionality of comorbid epilepsy and psychosis in Norway. Methods: The Norwegian Prescription Database (NorPD) provided individual-based information on all antiseizure medications ...
    • Challenges in epilepsy – the perspective of Norwegian epilepsy patients 

      Henning, Oliver Johannes; Landmark, Cecilie Johannessen; henning, david; Nakken, Karl Otto; Lossius, Morten (Acta Neurologica Scandinavica;Volume 140, Issue 1, July 2019, Journal article; Peer reviewed, 2019-04-08)
      Objectives: For most people with epilepsy (PWE), problems that are not directly related to seizures may constitute major challenges in everyday life. The purpose of this study was to determine the extent of these challenges ...
    • Changes in the use of antiseizure medications in children and adolescents in Norway, 2009–2018 

      Heger, Katrine; Skipsfjord, Julia; Kiselev, Yury; Burns, Margrete Larsen; Aaberg, Kari Modalsli; Johannessen, Svein Ivar; Skurtveit, Svetlana Ondrasova; Landmark, Cecilie Johannessen (Epilepsy Research;Volume 181, March 2022, 106872, Peer reviewed; Journal article, 2022-02-15)
      Background: The use of antiseizure medications (ASMs) in the pediatric population is poorly studied. The purpose of this study was to investigate changes in the use of ASMs in children and adolescents compared to adults, ...
    • Clinical experience combined with therapeutic drug monitoringof lacosamide 

      Svendsen, Torleiv; Brodtkorb, Eylert; Baftiu, Arton; Lossius, Morten; Nakken, Karl Otto; Johannessen, Svein Ivar; Landmark, Cecilie Johannessen (Acta Neurologica Scandinavica;Volume 141, Issue 4, Journal article; Peer reviewed, 2019-12-14)
      Objective: Lacosamide (LCM) is an antiepileptic drug (AED) with insufficient clinical experience in patients with intellectual disability (ID). They often have more severe epilepsy with comorbidities. The objective was to ...
    • Development and validation of a new non-disease-specific survey tool to assess self-reported adherence to medication 

      Larsen, Rønnaug; Pripp, Are Hugo; Krogstad, Tonje; Landmark, Cecilie Johannessen; Holm, Lene Berge (Frontiers in Pharmacology;Volume 13 - 2022, Peer reviewed; Journal article, 2022)
      Background: Patients’ non-adherence to medication affects both patients themselves and healthcare systems. Consequences include higher mortality, worsening of disease, patient injuries, and increased healthcare costs. Many ...
    • Drug interactions involving the new second- and third-generation antiepileptic drugs 

      Landmark, Cecilie Johannessen; Patsalos, Philip N. (Expert Review of Neurotherapeutics;10 (1), Academic article, 2010-01)
      During the period 1989-2009, 14 new antiepileptic drugs (AEDs) were licensed for clinical use and these can be subdivided into new second- and third-generation AEDs. The second-generation AEDs comprise felbamate, gabapentin, ...
    • Effect and tolerability of perampanel in patients with drug-resistant epilepsy 

      Lossius, Ida Marie Bakke; Svendsen, Torleiv; Sødal, Hild Flatmark; Kjeldstadli, Kari Grandaunet; Lossius, Morten Ingvar; Nakken, Karl Otto; Landmark, Cecilie Johannessen (Epilepsy & Behavior;Volume 119, June 2021, 107965, Peer reviewed; Journal article, 2021-04-30)
      Objective: Perampanel is one of the most recently approved antiseizure medications. The aim of the present study was to assess clinical efficacy and tolerability, in combination with pharmacokinetic variability, of perampanel ...
    • Effectiveness and safety of everolimus treatment in patients with tuberous sclerosis complex in real-world clinical practice 

      Cockerell, Ine Tracey; Christensen, Jakob; Hoei-Hansen, Christina; Holst, Lotte; Frediksen, Mikkel G; Issa-Epe, Aart I.; Nedregaard, Bård; Solhoff, Ragnar Håkon; Heimdal, Ketil Riddervold; Landmark, Cecilie Johannessen; Lund, Beate Caroline Pernille; Nærland, Terje (Peer reviewed; Journal article, 2023)
      Background The randomised double‑blinded placebo‑controlled EXIST‑1–3 studies have showed everolimus effective with adverse effects reported as acceptable in treatment of symptoms in patients with tuberous sclerosis complex ...
    • Epilepsy and cannabidiol: a guide to treatment 

      Arizmanoglou, Alexis; Brandl, Ulrich; Cross, Helen; Gil-nagel, Antonio; Lagae, Lieven; Landmark, Cecilie Johannessen; Specchio, Nicola; Nabbout, Rima; Thiele, Elisabeth; Gubbay, Oliver (Epileptic Disorders;Volume 22, Issue 1, February 2020, Journal article; Peer reviewed, 2020-12-19)
      The growing interest in cannabidiol (CBD), specifically a pure form of CBD, as a treatment for epilepsy, among other conditions, is reflected in recent changes in legislation in some countries. Although there has been much ...
    • Interactions between antiseizure medications and foods and drinks: A systematic review 

      Asadi-Pooya, Ali A.; Landmark, Cecilie Johannessen; Nafiseh Mirzaei, Damabi; Khatereh, Fazelian (Peer reviewed; Journal article, 2024)
      Antiseizure medications (ASMs) constitute the principal of treatment for patients with epilepsy, where long-term treatment is usually necessary. The purpose of this systematic review is to provide practical and useful ...
    • Lamotrigine effects on immune gene expression in larval zebrafish 

      Mochol, Monika; Whatmore, Paul; Taubøll, Erik; Landmark, Cecilie Johannessen; Ropstad, Erik; Svalheim, Sigrid; Fraser, Thomas (Epilepsy Research;Volume 178, December 2021, 106823, Peer reviewed; Journal article, 2021-11-26)
      Purpose: Despite growing evidence that neuroinflammation and pro-inflammatory cytokines are involved in the pathogenesis of seizures and epilepsy, this knowledge has not been incorporated in the proposed mechanism of action ...
    • Legemidler og pasientsikkerhet - fokus på eldre 

      Hagesæter, Ellen; Landmark, Cecilie Johannessen; Neslein, Inger-Lise; Granås, Anne Gerd (Journal article; Peer reviewed, 2015)
    • Long-term follow-up with therapeutic drug monitoring of antiepileptic drugs in patients with juvenile myoclonic epilepsy 

      Landmark, Cecilie Johannessen; Fløgstad, Ida; Baftiu, Arton; Syvertsen, Marte Roa; Enger, Ulla Helene; Johannessen, Svein Ivar (Epilepsy Research;Volume 155, September 2019, Journal article; Peer reviewed, 2019-05-30)
      Background and purpose: Patients with juvenile myoclonus epilepsy (JME) may experience uncontrolled seizures and challenges regarding adherence. Implementation of therapeutic drug monitoring (TDM) may contribute to ...
    • Nonadherence to treatment regimens in epilepsy from the patient's perspective and predisposing factors: Differences between intentional and unintentional lack of adherence 

      Henning, Oliver Johannes; Landmark, Cecilie Johannessen; Nakken, Karl Otto; Lossius, Morten (Epilepsia;Volume 61, Issue 2 February 2020, Journal article; Peer reviewed, 2019)
      Nonadherence to recommended antiepileptic drug (AED) treatment regimens can result in seizure relapse with increased health risks. Nonadherence can be unintentional (eg, patients forget to take a dose), or intentional, ...
    • Pharmacokinetic variability and clinical use of lacosamide in children and adolescents in Denmark and Norway 

      Burns, Margrete Larsen; Nikanorova, Marina; Baftiu, Arton; Rasmussen, Jan Borg; Johannessen, Svein Ivar; Landmark, Cecilie Johannessen (Therapeutic Drug Monitoring;41 (3): 340–347, JUNE 2019, Journal article; Peer reviewed, 2019-01-01)
      Background: The indication for the antiepileptic drug (AED) lacosamide (LCM) was recently extended to include children from the age of four. Real-life data on the use and serum concentrations of LCM in children and ...
    • Pharmacological aspects of antiseizure medications: From basic mechanisms to clinical considerations of drug interactions and use of therapeutic drug monitoring 

      Landmark, Cecilie Johannessen; Eyal, Sara; Burns, Margrete Larsen; Franco, Valentina; Johannessen, Svein Ivar (Journal article; Peer reviewed, 2023)
      Antiseizure medications (ASMs) are the cornerstone of treatment for patients with epilepsy. Several new ASMs have recently been introduced to the market, making it possible to better tailor the treatment of epilepsy, as ...
    • Pharmacology and drug interactions of cannabinoids 

      Landmark, Cecilie Johannessen; Ulrich, Brandl (Epileptic Disorders;Vol. 22, Supplement 1, Journal article; Peer reviewed, 2020)
      Cannabinoids include a variety of substances, of which cannabidiol (CBD) is the main substance investigated for the treatment of epilepsy, and this will be the focus in the present review. CBD preparations exist in various ...
    • Reference ranges for antiepileptic drugs revisited: a practical approach to establish national guidelines 

      Reimers, Arne; Berg, Jon Andsnes; Burns, Margrete Larsen; Brodtkorb, Eylert; Johannessen, Svein Ivar; Landmark, Cecilie Johannessen (Journal article; Peer reviewed, 2018)
      Background and objective: Laboratories sometimes use different reference ranges for the same antiepileptic drug (AED), particularly for new and poorly investigated drugs. This may contribute to misunderstandings, concerns ...