Browsing ODA Open Digital Archive by Author "Charnock, Colin"
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2-Substituted agelasine analogs : synthesis and biological activity, and structure and reactivity of synthetic intermediates
Roggen, Heidi; Bohlin, Lars; Burman, Robert; Charnock, Colin; Felth, Jenny; Gorbitz, Carl Henrik; Larsson, Rolf; Tamm, Toomas; Gundersen, Lise-Lotte (Pure and Applied Chemistry;83 (3), Journal article; Peer reviewed, 2011-01-25)2-Substituted N-methoxy-9-methyl-9H-purin-6-amines were synthesized either from their corresponding 6-chloro-9-methyl-9H-purines or 2-chloro-N-methoxy-9-methyl- 9H-purin-6-amine. Great diversity in the amino/imino tautomeric ... -
Activity of 6-aryl-pyrrolo[2,3-d]pyrimidine-4-amines to Tetrahymena
Kaspersen, Svein Jacob; Sundby, Eirik; Charnock, Colin; Hoff, Bård Helge (Bioorganic chemistry;, Journal article; Peer reviewed, 2012-06-05)A series 6-aryl-pyrrolo[2,3-d]pyrimidine-4-amines (43 compounds), some of which are epidermal growth 22 factor tyrosine kinase inhibitors, were tested for their protozoal toxicity using an environmental Tetrahy- 23 mena ... -
Agar og fosfat – ikke så skjønn forening
Charnock, Colin (Peer reviewed; Journal article, 2023)Bakgrunn: Varmesterilisering av agar og andre geleringsmidler vil i nærvær av fosfat resultere i produksjon av hydrogenperoksid (H2O2) og sannsynligvis andre reaktive oksygenforbindelser (ROS). Disse stoffene begrenser ... -
Can the use of assistive technology and interactive therapeutic robots in nursing homes contribute to the spread of infectious disease?
Klein, Jörn; Hjeltnes, Bjarne; Tunsjø, Hege; Charnock, Colin (Canadian Journal of Infection Control;Volume 32, Number 4, Journal article; Peer reviewed, 2017)Background: There is an increasing use of assistive technology and interactive therapeutic robots in nursing homes. However, little is known about the possible risks for transmitting infectious diseases through the use ... -
Chiral N-benzyl-N-methyl-1-(naphthalen-1-yl)ethanamines and their in vitro antifungal activity against Cryptococcus neoformans, Trichophyton mentagrophytes and Trichophyton rubrum
Tvedt, Thor Håkon Krane; Kaasa, Kristin; Sundby, Erik; Charnock, Colin; Hoff, Bård Helge (European Journal of Medicinal Chemistry;68, Journal article; Peer reviewed, 2013-10)In the search for new antifungal compounds and to explore structure activity relationships, a series of 24 chiral benzyl amine type antifungals was synthesised and characterised. In vitro testing against the human pathogen ... -
Detection of Aminoglycoside Resistant Bacteria in Sludge Samples From Norwegian Drinking Water Treatment Plants
Ullman, Ingvild F.; Tunsjø, Hege; Andreassen, Monica; Nielsen, Kaare Magne; Lund, Vidar; Charnock, Colin (Frontiers in Microbiology; March 2019 | Volume 10 | Article 487, Journal article; Peer reviewed, 2019-03-13)Through a culture-based approach using sludge from drinking water treatment plants, this study reports on the presence of aminoglycoside resistant bacteria at 23 different geographical locations in Norway. Sludge samples ... -
Diversion and phylogenetic relatedness of filterable bacteria from Norwegian tap and bottled waters
Charnock, Colin; Hagen, Ralf Xue; Nguyen, Theresa Ngoc-Thu; Vo, Linh Thuy (Journal of Water & Health;Volume 17 Issue 2, Journal article; Peer reviewed, 2019-02-22)Numerous articles have documented the existence of filterable bacteria. Where filtration is the chosen method of sterilization for medicinal or media components, these bacteria will by definition render products non-sterile. ... -
The effect of toll-like receptor ligands on energy metabolism and myokine expression and secretion in cultured human skeletal muscle cells
Tingstad, Ragna Husby; Norheim, Frode Amador; Haugen, Fred; Feng, Yuan Zeng; Tunsjø, Hege; Thoresen, G. Hege; Rustan, Arild Christian; Charnock, Colin; Aas, Vigdis (Scientific Reports;11, Article number: 24219 (2021), Peer reviewed; Journal article, 2021-12-20)Skeletal muscle plays an important role in glycaemic control and metabolic homeostasis, making it a tissue of interest with respect to type 2 diabetes mellitus. The aim of the present study was to determine if ligands of ... -
Hva finnes på innsiden av kranarmaturer?
Charnock, Colin; Otterholt, Eli; Nordlie, Anne-Lise (Vann;, Journal article; Peer reviewed, 2012)Innsiden av vannkraner kommer i kontakt med både mikrober som er til stede i drikkevann og de som finnes på hender, matrester og i luften. En hypotese er at kranbiofilmer kan være tilholdssted for sykdomsfremkallende ... -
Implications of stx loss for clinical diagnostics of Shiga toxin-producing Escherichia coli
Senthakumaran, Thulasika; Brandal, Lin Cathrine T.; Lindstedt, Bjørn-Arne; Jørgensen, Silje Bakken; Charnock, Colin; Tunsjø, Hege (European Journal of Clinical Microbiology and Infectious Diseases;Volume 37, Issue 12, Journal article; Journal article; Peer reviewed, 2018-09-28)The dynamics related to the loss of stx genes from Shiga toxin-producing Escherichia coli remain unclear. Current diagnostic procedures have shortcomings in the detection and identification of STEC. This is partly owing ... -
Longitudinal development of the dust microbiome in a newly opened Norwegian kindergarten
Nygaard, Anders Benteson; Charnock, Colin (Microbiome;(2018) 6:159, Journal article; Peer reviewed, 2018-09-15)Background In Norway, 91% of children aged 1–5 attend kindergarten where they are exposed to indoor microbiomes which can have relevance for development and health. In order to gain a better understanding of the composition ... -
Microbial Quality and Nutritional Aspects of Norwegian Brand Waters
Otterholt, Eli; Charnock, Colin (International Journal of Food Microbiology;144 (3), Journal article; Peer reviewed, 2010-11-04)The microbiological quality of the five leading brands of Norwegian bottled still waters was investigated. All brands were free for the enteric indicator organisms and named pathogens whose absence is demanded in current ... -
Norwegian Soils and Waters Contain Mesophilic, Plastic-Degrading Bacteria
Charnock, Colin (Microorganisms;Volume 9, Issue 1, Journal article; Peer reviewed, 2021-01-03)Plastic pollution has become one of the most critical environmental issues, as rapidly increasing production, compounded by persistence of plastic wastes in the environment, are outpacing efforts to keep ecosystems ... -
Positioning of community pharmacists in interactions with general practitioners and patients regarding prescribing and using antibiotics
Rochette, Yngvild Bergsholm; Feiring, Marte; Charnock, Colin; Krogstad, Tonje; Holm, Lene Berge (Journal of Interprofessional Care;, Peer reviewed; Journal article, 2023)Interprofessional collaboration between general practitioners (GPs) and community pharmacists (CPs) is important for ensuring antibiotics are used correctly and combating antibiotic resistance. The study’s main objective ... -
A preliminary study of the use of MinION sequencing to specifcally detect Shiga toxin‑producing Escherichia coli in culture swipes containing multiple serovars of this species
Tunsjø, Hege; Ullmann, Ingvild Falkum; Charnock, Colin (Peer reviewed; Journal article, 2023)An important challenge relating to clinical diagnostics of the foodborne pathogen Shiga toxin-producing E. coli (STEC), is that PCR-detection of the shiga-toxin gene (stx) in DNA from stool samples can be accompanied by a ... -
A preliminary study on the potential of Nanopore MinION and Illumina MiSeq 16S rRNA gene sequencing to characterize building-dust microbiomes
Nygaard, Anders Benteson; Tunsjø, Hege; Meisal, Roger; Charnock, Colin (Scientific Reports;10, Article number: 3209 (2020), Journal article; Peer reviewed, 2020-01-30)There is a growing awareness of the importance of indoor microbiomes for human health. Given their complexity, these microbiomes can only be adequately surveyed using high throughput sequencing techniques. Oxford Nanopore's ... -
Proteobacteria, extremophiles and unassigned species dominate in a tape-like showerhead biofilm.
Charnock, Colin; Nordlie, Anne-Lise (Journal article; Peer reviewed, 2016)The development of showerhead biofilms exposes the user to repeated contact with potentially pathogenic microbes, yet we know relatively little about the content of these aggregates. The aim o ... -
A simple and novel method for the production of polyethylene terephthalate containing agar plates for the growth and detection of bacteria able to hydrolyze this plastic
Charnock, Colin (Journal of Microbiological Methods;volume 85, Peer reviewed; Journal article, 2021-04-16)Polyethylene terephthalate is used in the manufacture of many products. Microbes able to hydrolyze the plastic are known, and offer promise for practical waste management. Screening for hydrolysis usually involves unwieldy ... -
Synthesis and antimycobacterial activities of non-purine analogs of 6-aryl-9-benzylpurines; imidazopyridines, pyrrolopyridines, benzimidazoles and indoles
Khoje, Abhijit Datta; Charnock, Colin; Wan, Baojie; Franzblau, Scott; Gundersen, Lise-Lotte (Bioorganic & Medicinal Chemistry;19, Journal article; Peer reviewed, 2011-04-20)6,9-Disubstituted purines and 7-deazapurines are known to be powerful inhibitors of Mycobacterium tuberculosis (Mtb) in vitro. Analogs modified in the six-membered ring (imidazopyridines, pyrrolopyridines, benzimidazoles, ...