dc.contributor.author | Aziz, Sura Mohammed | |
dc.contributor.author | Wik, Elisabeth | |
dc.contributor.author | Knutsvik, Gøril | |
dc.contributor.author | Klingen, Tor Audun | |
dc.contributor.author | Chen, Ying | |
dc.contributor.author | Davidsen, Benedicte | |
dc.contributor.author | Aas, Hans | |
dc.contributor.author | Aas, Turid | |
dc.contributor.author | Akslen, Lars A | |
dc.date.accessioned | 2019-07-16T08:41:31Z | |
dc.date.available | 2019-07-16T08:41:31Z | |
dc.date.issued | 2017-02-15 | |
dc.identifier.citation | Aziz, S., Wik, E., Knutsvik, G., Klingen, T. A., Chen, Y., Davidsen, B., ... & Akslen, L. A. (2017). Extra-nodal extension is a significant prognostic factor in lymph node positive breast cancer. PloS one, 12(2), e0171853. | en |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | https://hdl.handle.net/10642/7317 | |
dc.description.abstract | Presence of lymph node (LN) metastasis is a strong prognostic factor in breast cancer, whereas the importance of extra-nodal extension and other nodal tumor features have not yet been fully recognized. Here, we examined microscopic features of lymph node metastases and their prognostic value in a population-based cohort of node positive breast cancer (n = 218), as part of the prospective Norwegian Breast Cancer Screening Program NBCSP (1996–2009). Sections were reviewed for the largest metastatic tumor diameter (TD-MET), nodal afferent and efferent vascular invasion (AVI and EVI), extra-nodal extension (ENE), number of ENE foci, as well as circumferential (CD-ENE) and perpendicular (PD-ENE) diameter of extra-nodal growth. Number of positive lymph nodes, EVI, and PD-ENE were significantly increased with larger primary tumor (PT) diameter. Univariate survival analysis showed that several features of nodal metastases were associated with disease-free (DFS) or breast cancer specific survival (BCSS). Multivariate analysis demonstrated an independent prognostic value of PD-ENE (with 3 mm as cut-off value) in predicting DFS and BCSS, along with number of positive nodes and histologic grade of the primary tumor (for DFS: P = 0.01, P = 0.02, P = 0.01, respectively; for BCSS: P = 0.02, P = 0.008, P = 0.02, respectively). To conclude, the extent of ENE by its perpendicular diameter was independently prognostic and should be considered in line with nodal tumor burden in treatment decisions of node positive breast cancer. | en |
dc.language.iso | en | en |
dc.publisher | PLOS | en |
dc.relation.ispartofseries | PloS one;12(2) | |
dc.rights | Attribution 3.0 United States
This is an open access article, originally published at http://dx.doi.org/10.1371/journal.pone.0171853 | en |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
dc.subject | Artikkel | en |
dc.subject | VDP::Medisinske Fag: 700 | en |
dc.title | Extra-nodal extension is a significant prognostic factor in lymph node positive breast cancer | en |
dc.type | Journal article | en |
dc.type | Peer reviewed | en |
dc.description.version | publishedVersion | en |
dc.identifier.doi | http://dx.doi.org/10.1371/journal.pone.0171853 | |
dc.identifier.cristin | 1451716 | |