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dc.contributor.authorTashbayev, Behzod
dc.contributor.authorUtheim, Tor Paaske
dc.contributor.authorUtheim, Øygunn Aass
dc.contributor.authorRæder, Sten
dc.contributor.authorJensen, Janicke Cecilie Liaaen
dc.contributor.authorYazdani, Mazyar
dc.contributor.authorLagali, Neil Satish
dc.contributor.authorVitelli, Valeria
dc.contributor.authorDartt, Darlene Ann
dc.contributor.authorChen, Xiangjun
dc.identifier.citationTashbayev B, Utheim, Utheim, Ræder, Jensen, Yazdani, Lagali, Vitelli, Dartt, Chen. Utility of Tear Osmolarity Measurement in Diagnosis of Dry Eye Disease. Scientific Reports. 2020en
dc.description.abstractThe prevalence of dry eye disease is high worldwide and poses a great burden on patients’ daily lives. Accurate diagnosis of the disease is important, and it requires application of various methods. Hyperosmolarity is believed to be the disease marker and thus measuring it provides useful information. In this study we investigated utility of tear osmolarity measured with TearLab osmometer, along with other diagnostic tests (Ocular Surface Disease Index questionnaire, Tear flm break-up time, Ocular Protection Index, Ocular Surface Staining, Schirmer I test, Meibomian gland functionality in 757 patients (1514 eyes) with dry eye disease and 29 healthy controls (58 eyes). Statistical diferences between the patient group and the control group were observed for all the tests apart from tear osmolarity, regardless of cut-of value (>308mOsm/L, >316mOsm/L, and inter-eye diference >8mOsm/L). Moreover, in the receiver operating characteristics curve analyses tear osmolarity measurement could not discriminate dry eye disease pathological scores. Therefore, our study suggests that tear osmolarity measured with TearLab osmometer cannot be used as a key indicator of DED.en
dc.publisherNature Researchen
dc.relation.ispartofseriesScientific Reports;10, Article number: 5542 (2020)
dc.rightsCreative Commons Attribution 4.0 International (CC BY 4.0) Licenseen
dc.subjectConjunctival diseasesen
dc.subjectDiagnostic markersen
dc.subjectDry eyes
dc.subjectDry eye diseases
dc.subjectEye diseases
dc.titleUtility of Tear Osmolarity Measurement in Diagnosis of Dry Eye Diseaseen
dc.typeJournal articleen
dc.typePeer revieweden
dc.source.journalScientific Reports

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Except where otherwise noted, this item's license is described as Creative Commons Attribution 4.0 International (CC BY 4.0) License