The association of birthweight with age at natural menopause: a population study of women in Norway
dc.contributor.author | Bjelland, Elisabeth Krefting | |
dc.contributor.author | Gran, Jon Michael | |
dc.contributor.author | Hofvind, Solveig | |
dc.contributor.author | Eskild, Anne | |
dc.date.accessioned | 2020-02-17T09:21:54Z | |
dc.date.accessioned | 2020-02-18T11:53:50Z | |
dc.date.available | 2020-02-17T09:21:54Z | |
dc.date.available | 2020-02-18T11:53:50Z | |
dc.date.issued | 2019-09-10 | |
dc.identifier.citation | Bjelland EK, Gran JM, Hofvind S, Eskild A. The association of birthweight with age at natural menopause: a population study of women in Norway. International Journal of Epidemiology. 2019:1-9 | en |
dc.identifier.issn | 0300-5771 | |
dc.identifier.issn | 0300-5771 | |
dc.identifier.issn | 1464-3685 | |
dc.identifier.uri | https://hdl.handle.net/10642/8133 | |
dc.description.abstract | Background: Previous studies suggest that birthweight may influence age at natural menopause, but the evidence remains inconclusive. Thus, we aimed to estimate the association of birthweight with age at natural menopause. Methods: A retrospective population study of 164 608 women in Norway, aged 48–71years. Data were obtained by two self-administered questionnaires among participants in BreastScreen Norway during 2006–2014. We used Cox proportional hazard models to estimate hazard ratios and logistic regression models to estimate odds ratios of menopause according to birthweight. Restricted cubic splines were applied to allow for possible non-linear associations, and adjustments were made for year and country of birth. Results: Women with birthweight <2500g were median 51years at menopause (interquartile range 49–54years), whereas women with birthweight 3500–3999g were median 52years at menopause (interquartile range 49–54years). The hazard ratio of menopause decreased with increasing birthweight up until 3500g. At birthweights >3500g, we estimated no further decrease (P for non-linearity ¼ 0.007). Birthweight at 2500g increased the odds ratios of menopause before the age of 45 [1.20; 95% confidence interval (CI): 1.14–1.25] and the age of 40 (1.26; 95% CI: 1.15–1.38) compared with birthweight at 3500g. At birthweights 4000g and 4500g, the odds ratio estimates were very similar to the reference group and the CIs overlapped 1.00. Conclusions: We found a non-linear dose-relationship of birthweight with age at natural menopause, and low birthweight was associated with early natural menopause. | en |
dc.description.sponsorship | This work was supported by the Norwegian Cancer Society [grant number 6863294-2015 to E.K.B.]. | en |
dc.language.iso | en | en |
dc.publisher | Oxford University Press (OUP) | en |
dc.relation.ispartofseries | International Journal of Epidemiology;Published 21 October 2019 | |
dc.relation.uri | https://academic.oup.com/ije/advance-article/doi/10.1093/ije/dyz207/5601469 | |
dc.rights | © The Author(s) 2019. Published by Oxford University Press on behalf of the International Epidemiological Association. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/ by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contactjournals.permissions@oup.com | en |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject | Menopause ages | en |
dc.subject | Birthweights | en |
dc.subject | Early menopause | en |
dc.subject | Growth restrictions | en |
dc.subject | Population studies | en |
dc.subject | Primary ovarian insufficiencies | en |
dc.title | The association of birthweight with age at natural menopause: a population study of women in Norway | en |
dc.type | Journal article | en |
dc.type | Peer reviewed | en |
dc.date.updated | 2020-02-17T09:21:54Z | |
dc.description.version | publishedVersion | en |
dc.identifier.doi | https://dx.doi.org/10.1093/ije/dyz207 | |
dc.identifier.cristin | 1775205 | |
dc.source.journal | International Journal of Epidemiology | |
dc.relation.projectID | Kreftforeningen: 6863294-2015 |
Files in this item
This item appears in the following Collection(s)
-
HV - Institutt for naturvitenskapelige helsefag [407]
HV - Department of Life Sciences and Health
Except where otherwise noted, this item's license is described as © The Author(s) 2019. Published by Oxford University Press on behalf of the International Epidemiological Association. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/ by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contactjournals.permissions@oup.com