Show simple item record

dc.contributor.authorMyhrstad, Mari
dc.contributor.authorDe Mello, Vanessa D.
dc.contributor.authorDahlman, Ingrid
dc.contributor.authorKolehmainen, Marjukka
dc.contributor.authorPaananen, Jussi
dc.contributor.authorRundblad, Amanda
dc.contributor.authorCarlberg, Carsten
dc.contributor.authorOlstad, Ole Kristoffer
dc.contributor.authorPihlajamaki, Jussi
dc.contributor.authorHolven, Kirsten Bjørklund
dc.contributor.authorHermansen, Kjeld
dc.contributor.authorDragsted, Lars O.
dc.contributor.authorGunnarsdottir, Ingibjörg
dc.contributor.authorCloetens, Lieselotte
dc.contributor.authorStorm, Matilda Ulmius
dc.contributor.authorÅkesson, Björn
dc.contributor.authorRosqvist, Fredrik
dc.contributor.authorHukkanen, Janne
dc.contributor.authorHerzig, Karl-Heinz
dc.contributor.authorRisérus, Ulf
dc.contributor.authorThorsdottir, Inga
dc.contributor.authorPoutanen, Kaisa S.
dc.contributor.authorSavolainen, Markku J.
dc.contributor.authorSchwab, Ursula
dc.contributor.authorArner, Peter
dc.contributor.authorUusitupa, Matti
dc.contributor.authorUlven, Stine Marie
dc.date.accessioned2020-01-31T20:27:51Z
dc.date.accessioned2020-02-04T13:44:00Z
dc.date.available2020-01-31T20:27:51Z
dc.date.available2020-02-04T13:44:00Z
dc.date.issued2019-04-18
dc.identifier.citationMyhrstad MC, De Mello VD, Dahlman I, Kolehmainen M, Paananen J, Rundblad A, Carlberg C, Olstad OK, Pihlajamaki J, Holven KB, Hermansen K, Dragsted LO, Gunnarsdottir I, Cloetens L, Storm MU, Åkesson B, Rosqvist F, Hukkanen J, Herzig K, Risérus U, Thorsdottir I, Poutanen KS, Savolainen MJ, Schwab U, Arner P, Uusitupa M, Ulven S. Healthy Nordic Diet Modulates the Expression of Genes Related to Mitochondrial Function and Immune Response in Peripheral Blood Mononuclear Cells from Subjects with Metabolic Syndrome - A SYSDIET Sub-Study. Molecular Nutrition & Food Research. 2019;63(13)en
dc.identifier.issn1613-4125
dc.identifier.issn1613-4125
dc.identifier.issn1613-4133
dc.identifier.urihttps://hdl.handle.net/10642/8056
dc.description.abstractScope. To explore the effect of a healthy Nordic diet on the global transcriptome profile in peripheral blood mononuclear cells (PBMCs) of subjects with metabolic syndrome. Methods and results. Subjects with metabolic syndrome undergo a 18/24 week randomized intervention study comparing an isocaloric healthy Nordic diet with an average habitual Nordic diet served as control (SYSDIET study). Altogether, 68 participants are included. PBMCs are obtained before and after intervention and total RNA is subjected to global transcriptome analysis. 1302 probe sets are differentially expressed between the diet groups (p‐value < 0.05). Twenty‐five of these are significantly regulated (FDR q‐value < 0.25) and are mainly involved in mitochondrial function, cell growth, and cell adhesion. The list of 1302 regulated probe sets is subjected to functional analyses. Pathways and processes involved in the mitochondrial electron transport chain, immune response, and cell cycle are downregulated in the healthy Nordic diet group. In addition, gene transcripts with common motifs for 42 transcription factors, including NFR1, NFR2, and NF‐κB, are downregulated in the healthy Nordic diet group. Conclusion. These results suggest that benefits of a healthy diet may be mediated by improved mitochondrial function and reduced inflammation.en
dc.description.sponsorshipThe project was funded by NordForsk Nordic Centre of Excellencein Food, Nutrition and Health project 070014 (SYSDIET [Systems Biologyin Controlled Dietary Interventions and Cohort Studies]) and further, OsloMetropolitan University-OsloMet (Norway), University of Oslo (Norway),Throne Holst Foundation (Norway), Academy of Finland, SwedishResearch Council, Svenska Diabetesf ̈orbundet, SRP Diabetes, FinnishDiabetes Research Foundation, Finnish Foundation for CardiovascularResearch, the Sigrid Juselius Foundation, EVO funding from KuopioUniversity Hospital (Finland), the Druvan Foundation, Sk ̊ane UniversityHospital, the Heart-Lung Foundation, Diabetesfonden and FoundationCerealia (Sweden), the Danish Obesity Research Centre (DanORC,www.danorc.dk), the Danish Council for Strategic Research (DairyHealth,BioFunCarb) (Denmark), the Agricultural Productivity Fund, and theResearch Fund of the University of Iceland (Iceland).en
dc.language.isoenen
dc.publisherWileyen
dc.relation.ispartofseriesMolecular Nutrition and Food Research;Volume 63, Issue 13, July 2019
dc.rightsThis article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1002/mnfr.201801405. This article is protected by copyright. All rights reserved.en
dc.subjectGene expressionsen
dc.subjectHealthy nordic dietsen
dc.subjectMetabolic syndromesen
dc.subjectPeripheralblood mononuclear cellsen
dc.subjectTranscriptomesen
dc.titleHealthy Nordic Diet Modulates the Expression of Genes Related to Mitochondrial Function and Immune Response in Peripheral Blood Mononuclear Cells from Subjects with Metabolic Syndrome - A SYSDIET Sub-Studyen
dc.typeJournal articleen
dc.typePeer revieweden
dc.date.updated2020-01-31T20:27:51Z
dc.description.versionacceptedVersionen
dc.identifier.doihttps://dx.doi.org/10.1002/mnfr.201801405
dc.identifier.cristin1713989
dc.source.journalMolecular Nutrition & Food Research


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record