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dc.contributor.authorSmeland, Tor Eirik
dc.contributor.authorMüller, Fredrik
dc.contributor.authorBlomfeldt, Anita
dc.contributor.authorStavem, Knut
dc.contributor.authorAamot, Hege Vangstein
dc.date.accessioned2019-08-05T09:20:32Z
dc.date.available2019-08-05T09:20:32Z
dc.date.issued2017-07-24
dc.identifier.citationSmeland, T. E., Müller, F., Blomfeldt, A., Stavem, K., & Aamot, H. V. (2017). No associations established between single nucleotide polymorphisms in human Toll‐like receptor 2 and Toll‐interacting protein and Staphylococcus aureus bloodstream infections. Apmis, 125(10), 927-932.en
dc.identifier.issn0903-4641
dc.identifier.urihttps://hdl.handle.net/10642/7399
dc.description.abstractStaphylococcus aureus bloodstream infections (SABSI) are associated with high morbidity and mortality. The Toll‐like receptor 2 (TLR2) and Toll‐interacting protein (TOLLIP) are important in recognition and regulation of human innate immunity response to S. aureus. Single nucleotide polymorphisms (SNPs) in the TLR2 and TOLLIP encoding genes have been associated with disease, including BSI. The aim of this study was to examine potential associations between a selection of SNPs in the genes encoding TLR2 and TOLLIP, and predisposition, severity, and outcome of SABSI. All patients ≥18 years of age with at least one S. aureus positive blood culture collected from March 2011 through February 2014 at Akershus University Hospital, Lørenskog, Norway, were considered for inclusion. Patients attending elective orthopaedic surgery (total hip and knee replacements, lumbar surgery) served as a control group. The TLR2 Arg753Gln, TLR2 Pro631His, TOLLIP rs5743942, and rs5743867 polymorphisms were analysed using TaqMan SNP Genotyping Assays. A total of 209 SABSI patients and 295 controls were included. The TLR2 Arg753Gln and TLR2 Pro631His polymorphisms were infrequent with no homozygotes and <10% heterozygotes. The included TLR2 and TOLLIP polymorphisms were not associated with susceptibility to SABSI, severity, 30‐day all‐cause mortality, or SABSI caused by the clonal complex 30 (CC30) genotype.en
dc.description.sponsorshipNORGES FORSKNINGSRÅD Prosjektkode: 261669en
dc.language.isoenen
dc.publisherWileyen
dc.relation.ispartofseriesActa Pathologica, Microbiologica et Immunologica Scandinavica (APMIS);125(10)
dc.rightsThis is the peer reviewed version of the following article: Smeland, T. E., Müller, F., Blomfeldt, A., Stavem, K., & Aamot, H. V. (2017). No associations established between single nucleotide polymorphisms in human Toll‐like receptor 2 and Toll‐interacting protein and Staphylococcus aureus bloodstream infections. Apmis, 125(10), 927-932., which has been published in final form at https://doi.org/10.1111/apm.12734. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.en
dc.subjectArtikkelen
dc.subjectVDP::Medisinske Fag: 700en
dc.titleNo associations established between single nucleotide polymorphisms in human Toll-like receptor 2 and Toll-interacting protein and Staphylococcus aureus bloodstream infectionsen
dc.typeJournal articleen
dc.typePeer revieweden
dc.description.versionacceptedVersionen
dc.identifier.doihttps://doi.org/10.1111/apm.12734
dc.identifier.cristin1508305


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