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dc.contributor.authorLandmark, Cecilie Johannessen
dc.contributor.authorFløgstad, Ida
dc.contributor.authorSyvertsen, Marte Roa
dc.contributor.authorBaftiu, Arton
dc.contributor.authorEnger, Ulla Helene
dc.contributor.authorKoht, Jeanette
dc.contributor.authorJohannessen, Svein Ivar
dc.date.accessioned2019-08-04T19:36:25Z
dc.date.accessioned2019-08-05T07:18:30Z
dc.date.available2019-08-04T19:36:25Z
dc.date.available2019-08-05T07:18:30Z
dc.date.issued2019-07-19
dc.identifier.citationLandmark CJL, Fløgstad I, Syvertsen M, Baftiu A, Enger UH, Koht J, Johannessen Si. Treatment and challenges with antiepileptic drugs in patients with juvenile myoclonic epilepsy. Epilepsy & Behavior. 2019;98:110-116en
dc.identifier.issn1525-5050
dc.identifier.issn1525-5050
dc.identifier.issn1525-5069
dc.identifier.urihttps://hdl.handle.net/10642/7391
dc.description.abstractBackground: Patients with juvenile myoclonic epilepsy (JME) may have uncontrolled seizures. The purpose of this study was to investigate the use and challenges with antiepileptic drugs (AEDs) and the patients' view of these challenges. Method: A questionnaire about the use of AEDs, adherence to therapy, and quality of life was given to patients with JME recruited from Drammen Hospital. Data regarding AEDs were confirmed from medical records at Drammen Hospital, Norway (2007–2018). Additional clinical interviews were performed, and a mixed method approach was applied. Results: Ninety patients with defined JME diagnosis, 54/36 women/men aged 14–39 (mean: 25) years, were included. Only 29 (33%) were seizure-free.Within the last year, 21% experienced generalized tonic–clonic seizures (GTCS), and 68% hadmyoclonic jerks. Seventy-six (84%) used AEDs, 78% inmonotherapy. A total of 10 AEDswere used;: most commonly valproate (n = 33), lamotrigine (n = 27), and levetiracetam (n = 21). Two-thirds of valproate users were men while all other AEDs were used more in females than in men. Valproate and levetiracetam displayed better efficacy against GTCS than lamotrigine. One-third often/sometimes forgot their medication nonintentionally while 14% had intentional poor adherence. The majority reported good quality of life (76%). No significant correlations between the use of AEDs, use of valproate, poor adherence, quality of life score, and seizure freedom were demonstrated. Half of the patients had serum concentrations measured every year, and two thirds thought this was important. Qualitative interviews elucidated treatment challenges in JME;, adverse effect burden, adherence, and activities of daily life. Conclusion: Despite the use of AEDs in the majority of patients, only one-thirdwere seizure-free. Other challenges included polypharmacy, the use of valproate in women, and variable adherence. This points to a need for closer follow-up in patients with JME.en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.ispartofseriesEpilepsy & Behavior;Volume 98, Part A, September 2019
dc.rights© 2019 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAdherencesen
dc.subjectAntiepileptic drugs
dc.subjectJuvenile myoclonic epilepsy
dc.subjectTreatment challenges
dc.titleTreatment and challenges with antiepileptic drugs in patients with juvenile myoclonic epilepsyen
dc.typeJournal articleen
dc.typePeer revieweden
dc.date.updated2019-08-04T19:36:25Z
dc.description.versionpublishedVersionen
dc.identifier.doihttps://dx.doi.org/10.1016/j.yebeh.2019.05.021
dc.identifier.cristin1713916
dc.source.journalEpilepsy & Behavior


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© 2019 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Except where otherwise noted, this item's license is described as © 2019 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).