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dc.contributor.authorRutkovskiy, Arkady
dc.contributor.authorMalashicheva, Anna
dc.contributor.authorSullivan, Gareth
dc.contributor.authorBogdanova, Mariia
dc.contributor.authorKostareva, Anna
dc.contributor.authorStensløkken, Kåre-Olav
dc.contributor.authorFiane, Arnt E
dc.contributor.authorVaage, Ingvar Jarle
dc.date.accessioned2019-07-15T11:44:14Z
dc.date.available2019-07-15T11:44:14Z
dc.date.issued2017-09-22
dc.identifier.citationRutkovskiy, A., Malashicheva, A., Sullivan, G., Bogdanova, M., Kostareva, A., Stensløkken, K. O., ... & Vaage, J. (2017). Valve interstitial cells: the key to understanding the pathophysiology of heart valve calcification. Journal of the american heart association, 6(9), e006339.en
dc.identifier.issn2047-9980
dc.identifier.urihttps://hdl.handle.net/10642/7307
dc.description.abstractAortic valve stenosis due to calcification of the valve leaflets is the most common valve disease in the developed world. It is the third leading cause of cardiovascular disease.1 Risk factors include male gender, smoking, diabetes mellitus, hypertension, high levels of circulating lipids, and metabolic syndrome.2 Calcification was earlier believed to be a passive degenerative process, but it is now recognized as an active disease process driven by the cells native to the aortic valve.3, 4 The only option for treatment is heart surgery with implantation of a valve prosthesis. The heart valve prostheses are either mechanical, requiring life‐long anticoagulation treatment, or based on biological material, which will degenerate and calcify after 10 to 15 years. Implantation of heart valve prostheses has been characterized as “replacing one disease with another.” Understanding the cellular and molecular processes behind valve calcification may possibly lead to nonsurgical treatment.en
dc.description.sponsorshipThis work was supported by South‐Eastern Norway Regional Health Authority (grant 2013109), the National Association (Norway), the University of Oslo, The Norwegian Research Council, the Government of Russian Federation (grant 074‐U01), and the Russian Foundation of Basic Research (grant 17‐04‐01318).en
dc.language.isoenen
dc.publisherWileyen
dc.relation.ispartofseriesJournal of The American Heart Association;6(9)
dc.rightsAttribution-NonCommercial 3.0 United States This is an open access article, originally published at https://doi.org/10.1161/JAHA.117.006339en
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/*
dc.subjectArtikkelen
dc.subjectVDP::Medisinske Fag: 700en
dc.titleValve Interstitial Cells: The Key to Understanding the Pathophysiology of Heart Valve Calcificationen
dc.typeJournal articleen
dc.typePeer revieweden
dc.description.versionpublishedVersionen
dc.identifier.doihttps://doi.org/10.1161/JAHA.117.006339
dc.identifier.cristin1519032


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Attribution-NonCommercial 3.0 United States
This is an open access article, originally published at https://doi.org/10.1161/JAHA.117.006339
Med mindre annet er angitt, så er denne innførselen lisensiert som Attribution-NonCommercial 3.0 United States This is an open access article, originally published at https://doi.org/10.1161/JAHA.117.006339