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dc.contributor.authorBeisland, Christian
dc.contributor.authorJohannesen, Tom Bjørge
dc.contributor.authorKlepp, Olbjørn
dc.contributor.authorAxcrona, Ulrika
dc.contributor.authorTorgersen, Knut Martin
dc.contributor.authorKowalski, Jan
dc.contributor.authorSolli, Oddvar
dc.contributor.authorSandin, Rickard
dc.contributor.authorOldenburg, Jan
dc.identifier.citationBeisland, C., Johannesen, T. B., Klepp, O., Axcrona, U., Torgersen, K. M., Kowalski, J., ... & Oldenburg, J. (2017). Overall survival in renal cell carcinoma after introduction of targeted therapies: a Norwegian population-based study. OncoTargets and therapy, 10, 371.en
dc.description.abstractBackground: This population-wide retrospective, non-interventional registry study assessed changes in overall survival (OS) and factors influencing OS in Norwegian patients with renal cell carcinoma (RCC). Methods: Two population-wide health registries were used to identify all RCC patients with (mRCC) or without metastases diagnosed before (2002–2005) and after (2006–2008 and 2009–2011) introduction of targeted therapies. Median OS was estimated using Kaplan–Meier method. Cox proportional hazards regression modeling was used to identify prognostic factors. Results: Overall, 5,463 patients were diagnosed with RCC during 2002–2005 (n=1,898), 2006–2008 (n=1,631), and 2009–2011 (n=1,934); of these, 1,678 (31%) had mRCC. Patients diagnosed in 2009–2011 and 2006–2008 had significant (P<0.001) improvements in OS versus those diagnosed in 2002–2005: median OS, not reached and not reached versus 82.0 months in RCC; 14.0 and 12.0 months versus 9.0 months in mRCC. Similarly, OS improvements were seen in the primary and elderly (≥75 years) mRCC populations. Median OS was comparable (12 months) between clear cell and papillary mRCC, but it was longer (24.0 months) for chromophobe mRCC. Multivariate regression analyses showed that younger age, previous nephrectomy, and 1 or more prescriptions of targeted therapy were significantly associated with longer OS in mRCC patients. Conclusion: OS increased in RCC and mRCC patients in Norway between 2002 and 2011 following introduction of targeted therapies.en
dc.publisherDove Medical Pressen
dc.relation.ispartofseriesOncoTargets and therapy;10
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States This is an open acces article, originally published at
dc.subjectVDP::Medisinske Fag: 700en
dc.titleOverall Survival in Renal Cell Carcinoma after Introduction of Targeted Therapies: A Norwegian Population-Based Studyen
dc.typeJournal articleen
dc.typePeer revieweden

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Attribution-NonCommercial-NoDerivs 3.0 United States
This is an open acces article, originally published at
Med mindre annet er angitt, så er denne innførselen lisensiert som Attribution-NonCommercial-NoDerivs 3.0 United States This is an open acces article, originally published at