dc.contributor.author | Ofstad, Anne Pernille | |
dc.contributor.author | Ulimoen, Geir Reinvik | |
dc.contributor.author | Orvik, Elsa | |
dc.contributor.author | Birkeland, Kåre I | |
dc.contributor.author | Gullestad, Lars | |
dc.contributor.author | Fagerland, Morten | |
dc.contributor.author | Johansen, Odd Erik | |
dc.date.accessioned | 2019-07-12T11:43:57Z | |
dc.date.available | 2019-07-12T11:43:57Z | |
dc.date.issued | 2017-06-19 | |
dc.identifier.citation | Ofstad, A. P., Ulimoen, G. R., Orvik, E., Birkeland, K. I., Gullestad, L. L., Fagerland, M. W., & Johansen, O. E. (2017). Long-term follow-up of a hospital-based, multi-intervention programme in type 2 diabetes mellitus: impact on cardiovascular events and death. Journal of International Medical Research, 45(5), 1535-1552. | en |
dc.identifier.issn | 0300-0605 | |
dc.identifier.uri | https://hdl.handle.net/10642/7290 | |
dc.description.abstract | Objective
To report the long-term impact on cardiovascular (CV) outcomes and mortality of a 2-year hospital-based multi-interventional care programme as compared with general practitioner (GP)-provided standard care.
Methods
Patients with type 2 diabetes with ≥ 1 additional CV risk factor were randomized to 2 years of specialist-based, multi-intervention comprising lifestyle modification and specific pharmacological treatment, or GP-based standard care. After the 2-year intervention period, all participants returned to pre-study care, but were followed up for CV outcomes and mortality. The primary outcome was time to any first severe CV event or death.
Results
A total of 120 patients (31 women) were enrolled in the study. During the mean ± SD observational period of 8.7 ± 2.0 years, 27 patients (16 and 11 in the multi-intervention and standard care groups, respectively) experienced at least one primary outcome event, with a hazard ratio (HR) if allocated to the multi-intervention group of 1.73 (95% confidence interval (CI) 0.80, 3.75). The HR for total mortality was 1.82 (95% CI 0.66, 5.01).
Conclusions
Hospital-based multi-intervention in patients with type 2 diabetes mellitus improved long-term glycaemic control, but failed to reduce CV outcomes and deaths. | en |
dc.language.iso | en | en |
dc.publisher | SAGE | en |
dc.relation.ispartofseries | Journal of International Medical Research;45(5) | |
dc.rights | Attribution-NonCommercial 3.0 United States
This is an open access article, originally published at https://doi.org/10.1177/0300060517707674 | en |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/us/ | * |
dc.subject | Artikkel | en |
dc.subject | VDP::Medisinske Fag: 700 | en |
dc.title | Long-term follow-up of a hospital-based, multi-intervention programme in type 2 diabetes mellitus: impact on cardiovascular events and death | en |
dc.type | Journal article | en |
dc.type | Peer reviewed | en |
dc.description.version | publishedVersion | en |
dc.identifier.doi | https://doi.org/10.1177/0300060517707674 | |
dc.identifier.cristin | 1521547 | |