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dc.contributor.authorPinto, M
dc.contributor.authorSolevåg, Anne Lee
dc.contributor.authorO´Reilly, Megan
dc.contributor.authorAziz, Khalid
dc.contributor.authorCheung, Po-Yin
dc.contributor.authorSchmölzer, Georg M
dc.date.accessioned2019-07-11T12:20:20Z
dc.date.available2019-07-11T12:20:20Z
dc.date.issued2016-12
dc.identifier.citationPinto, M., Solevag, A. L., O'Reilly, M., Aziz, K., Cheung, P. Y., & Schmolzer, G. M. (2017). Evidence on Adrenaline Use in Resuscitation and Its Relevance to Newborn Infants: A Non-Systematic Review. Neonatology, 111(1), 37-44. doi:10.1159/000447960en
dc.identifier.issn1661-7800
dc.identifier.urihttps://hdl.handle.net/10642/7269
dc.description.abstractAIM: Guidelines for newborn resuscitation state that if the heart rate does not increase despite adequate ventilation and chest compressions, adrenaline administration should be considered. However, controversy exists around the safety and effectiveness of adrenaline in newborn resuscitation. The aim of this review was to summarise a selection of the current knowledge about adrenaline during resuscitation and evaluate its relevance to newborn infants. METHODS: A search in PubMed, Embase, and Google Scholar until September 1, 2015, using search terms including adrenaline/epinephrine, cardiopulmonary resuscitation, death, severe brain injury, necrotizing enterocolitis, bronchopulmonary dysplasia, and adrenaline versus vasopressin/placebo. RESULTS: Adult data indicate that adrenaline improves the return of spontaneous circulation (ROSC) but not survival to hospital discharge. Newborn animal studies reported that adrenaline might be needed to achieve ROSC. Intravenous administration (10-30 mug/kg) is recommended; however, if there is no intravenous access, a higher endotracheal dose (50-100 mug/kg) is needed. The safety and effectiveness of intraosseous adrenaline remain undetermined. Early and frequent dosing does not seem to be beneficial. In fact, negative hemodynamic effects have been observed, especially with doses >/=30 mug/kg intravenously. Little is known about adrenaline in birth asphyxia and in preterm infants, but observations indicate that hemodynamics and neurological outcomes may be impaired by adrenaline administration in these conditions. However, a causal relationship between adrenaline administration and outcomes cannot be established from the few available retrospective studies. Alternative vasoconstrictors have been investigated, but the evidence is scarce. CONCLUSION: More research is needed on the benefits and risks of adrenaline in asphyxia-induced bradycardia or cardiac arrest during perinatal transition.en
dc.language.isoenen
dc.publisherKargeren
dc.relation.ispartofseriesNeonatology;111(1)
dc.rightsThis is a postprint of a published article. The final, published version of this article is available at http://www.karger.com/?doi=10.1159/000447960en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectVDP::Medisinske Fag: 700en
dc.subjectArtikkelen
dc.titleEvidence on Adrenaline Use in Resuscitation and Its Relevance to Newborn Infants: A Non-Systematic Reviewen
dc.typeJournal articleen
dc.typePeer revieweden
dc.description.versionacceptedVersionen
dc.identifier.doihttp://dx.doi.org/10.1159/000447960
dc.identifier.cristin1485239


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This is a postprint of a published article. The final, published version of this article is available at http://www.karger.com/?doi=10.1159/000447960
Med mindre annet er angitt, så er denne innførselen lisensiert som This is a postprint of a published article. The final, published version of this article is available at http://www.karger.com/?doi=10.1159/000447960