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dc.contributor.authorOttestad, Inger
dc.contributor.authorUlven, Stine Marie
dc.contributor.authorØyri, Linn Kristin Lie
dc.contributor.authorSandvei, Kristin Søfteland
dc.contributor.authorGjevestad, Gyrd Omholt
dc.contributor.authorBye, Asta
dc.contributor.authorSheikh, Navida Akhter
dc.contributor.authorBiong, Anne Sofie
dc.contributor.authorAndersen, Lene Frost
dc.contributor.authorHolven, Kirsten Bjørklund
dc.date.accessioned2019-02-14T07:11:21Z
dc.date.accessioned2019-05-22T10:48:02Z
dc.date.available2019-02-14T07:11:21Z
dc.date.available2019-05-22T10:48:02Z
dc.date.issued2018-06-18
dc.identifier.citationOttestad I, Ulven S, Øyri LKØ, Sandvei KS, Gjevestad GOG, Bye A, Sheikh NA, Biong AS, Andersen LF, Holven KB. Reduced plasma concentration of branched-chain amino acids in sarcopenic older subjects: a cross-sectional study. British Journal of Nutrition. 2018;120(4):445-453en
dc.identifier.issn0007-1145
dc.identifier.issn0007-1145
dc.identifier.issn1475-2662
dc.identifier.urihttps://hdl.handle.net/10642/7145
dc.description.abstractBranched chain amino acids (BCAAs) are essential amino acids necessary for muscle mass maintenance. Little is known about the plasma concentrations of BCAAs and the protein intake in relation to sarcopenia. We aimed to compare the non-fasting plasma concentrations of the BCAAs and the dietary protein intake between sarcopenic and nonsarcopenic older adults. Norwegian older home-dwelling adults (≥ 70 years) were invited to a cross-sectional study with no other exclusion criteria than age. Sarcopenic subjects were defined by the diagnostic criteria by the European Working Group on Sarcopenia in Older People. Non- fasting plasma concentrations of eight amino acids were quantified using nuclear magnetic resonance (NMR) spectroscopy. Protein intake was assessed using 2 x 24-h dietary recalls. In this study, 90 out of 417 subjects (22 %) were sarcopenic, and more women (32 %) than men (11 %) were sarcopenic (P < 0.0001). Gender-adjusted non-fasting plasma concentrations of leucine and isoleucine, and the absolute intake of protein (g/d) were significantly lower among the sarcopenic subjects, when compared to nonsarcopenic subjects (P = 0.003, P = 0.026 and P = 0.003, respectively). A similar protein intake was observed in the two groups when adjusted for body weight and gender (1.1 g protein/kg BW/d; P = 0.50). We show that sarcopenia is associated with reduced non-fasting plasma concentration of the BCAAs leucine and isoleucine, and lower absolute intake of protein. More studies are needed to clarify the clinical relevance of these findings, related to maintenance of muscle mass and prevention of sarcopenia.en
dc.language.isoenen
dc.publisherCambridge University Pressen
dc.relation.ispartofseriesBritish Journal of Nutrition;Volume 120, Issue 4
dc.subjectSarcopeniaen
dc.subjectBranched chain amino acidsen
dc.subjectLeucineen
dc.subjectProtein intakeen
dc.subjectElderly peopleen
dc.titleReduced plasma concentration of branched-chain amino acids in sarcopenic older subjects: a cross-sectional studyen
dc.typeJournal articleen
dc.typePeer revieweden
dc.date.updated2019-02-14T07:11:20Z
dc.description.versionpublishedVersionen
dc.identifier.doihttps://dx.doi.org/10.1017/S0007114518001307
dc.identifier.cristin1617945
dc.source.journalBritish Journal of Nutrition


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