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Reduced plasma concentration of branched-chain amino acids in sarcopenic older subjects: a cross-sectional study

Ottestad, Inger; Ulven, Stine Marie; Øyri, Linn Kristin Lie; Sandvei, Kristin Søfteland; Gjevestad, Gyrd Omholt; Bye, Asta; Sheikh, Navida Akhter; Biong, Anne Sofie; Andersen, Lene Frost; Holven, Kirsten Bjørklund
Journal article, Peer reviewed
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URI
https://hdl.handle.net/10642/7145
Date
2018-06-18
Metadata
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  • HV - Institutt for sykepleie og helsefremmende arbeid [1301]
Original version
Ottestad I, Ulven S, Øyri LKØ, Sandvei KS, Gjevestad GOG, Bye A, Sheikh NA, Biong AS, Andersen LF, Holven KB. Reduced plasma concentration of branched-chain amino acids in sarcopenic older subjects: a cross-sectional study. British Journal of Nutrition. 2018;120(4):445-453   https://dx.doi.org/10.1017/S0007114518001307
Abstract
Branched chain amino acids (BCAAs) are essential amino acids necessary for muscle mass

maintenance. Little is known about the plasma concentrations of BCAAs and the protein

intake in relation to sarcopenia. We aimed to compare the non-fasting plasma concentrations

of the BCAAs and the dietary protein intake between sarcopenic and nonsarcopenic older

adults. Norwegian older home-dwelling adults (≥ 70 years) were invited to a cross-sectional

study with no other exclusion criteria than age. Sarcopenic subjects were defined by the

diagnostic criteria by the European Working Group on Sarcopenia in Older People. Non-

fasting plasma concentrations of eight amino acids were quantified using nuclear magnetic

resonance (NMR) spectroscopy. Protein intake was assessed using 2 x 24-h dietary recalls. In

this study, 90 out of 417 subjects (22 %) were sarcopenic, and more women (32 %) than men

(11 %) were sarcopenic (P < 0.0001). Gender-adjusted non-fasting plasma concentrations of

leucine and isoleucine, and the absolute intake of protein (g/d) were significantly lower

among the sarcopenic subjects, when compared to nonsarcopenic subjects (P = 0.003, P =

0.026 and P = 0.003, respectively). A similar protein intake was observed in the two groups

when adjusted for body weight and gender (1.1 g protein/kg BW/d; P = 0.50). We show that

sarcopenia is associated with reduced non-fasting plasma concentration of the BCAAs leucine

and isoleucine, and lower absolute intake of protein. More studies are needed to clarify the

clinical relevance of these findings, related to maintenance of muscle mass and prevention of

sarcopenia.
Publisher
Cambridge University Press
Series
British Journal of Nutrition;Volume 120, Issue 4
Journal
British Journal of Nutrition

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