• A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis. 

      Madireddy, L; Patsopoulos, NA; Cotsapas, C; Bos, Steffan Daniel; Beecham, Ashley; McCauley, J; Kim, K; Jia, X; Santaniello, A; Caillier, SJ; Andlauer, TFM; Barcellos, Lisa; Berge, Tone; Bernardinelli, L; Martinelli-Boneschi, F; Booth, D; Briggs, Farren; Celius, Elisabeth Gulowsen; Comabella, M; Comi, G; Cree, BAC; D'Alfonso, S; Dedham, K; Duquette, P.; Dardiotis, E; Esposito, F; Gasperi, Christiane; Goris, A; Dubois, B; Gourraud, PA; Hadjigeorgiou, GM; Haines, J; Hawkins, C; Hemmer, B; Hintzen, R; Horakova, D; Isobe, N; Kalra, S; Kira, Jun-ichi; Khalil, M; Kockum, I; Lill, CM; Lincoln, Michelle; Luessi, F; Martin, R; Oturai, A; Palotie, A; Pericak-Vance, MA; Henry, R; Saarela, J; Ivinson, Adrian; Olsson, Thomas; Taylor, Bruce; Stewart, GJ; Harbo, Hanne Flinstad; Compston, A; Hauser, SL; Hafler, DA; Zipp, F; De Jager, P; Sawcer, S; Oksenberg, JR; Baranzini, SE (Nature Communications;10, Article number: 2236 (2019), Journal article; Peer reviewed, 2019-03-26)
      Genome-wide association studies (GWAS) have identified more than 50,000 unique associations with common human traits. While this represents a substantial step forward, establishing the biology underlying these associations ...