Blar i HV - Institutt for naturvitenskapelige helsefag på emneord "Glucuronidation"

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    • Effects of a Novel UGT2B Haplotype and UGT1A4*3 Allele Variants on Glucuronidation of Clozapine In vivo 

      Smith, Robert Løvsletten; Wollmann, Birgit Malene Tovik; Kausberg, Marianne; Mæland, Sondre; Tveito, Marit; O'Connell, Kevin Sean; Molden, Espen; Kringen, Marianne K. (Current drug metabolism;Volume 23, Issue 1, Peer reviewed; Journal article, 2022)
      Background: Glucuronidation is an important metabolic pathway of clozapine (CLZ), but the impact of various uridine 5'diphospho-glucuronosyltransferases (UGT) polymorphisms on the exposure and metabolism of CLZ in vivo is ...