Browsing HV - Institutt for naturvitenskapelige helsefag by Subject "Clozapine"
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Effects of a Novel UGT2B Haplotype and UGT1A4*3 Allele Variants on Glucuronidation of Clozapine In vivo
(Current drug metabolism;Volume 23, Issue 1, Peer reviewed; Journal article, 2022)Background: Glucuronidation is an important metabolic pathway of clozapine (CLZ), but the impact of various uridine 5'diphospho-glucuronosyltransferases (UGT) polymorphisms on the exposure and metabolism of CLZ in vivo is ... -
Identification of a novel polymorphism associated with reduced clozapine concentration in schizophrenia patients—a genome-wide association study adjusting for smoking habits
(Translational Psychiatry; 10, Article number: 198 (2020), Journal article; Peer reviewed, 2020-06-19)Clozapine (CLZ) is the superior antipsychotic drug for treatment of schizophrenia, but exhibits an extensive interpatient pharmacokinetic variability. Here, we conducted a genome-wide association study (GWAS) of CLZ serum ...