dc.contributor.author | Sowa, Piotr | |
dc.contributor.author | Harbo, Hanne Flinstad | |
dc.contributor.author | White, Nathan S. | |
dc.contributor.author | Celius, Elisabeth Gulowsen | |
dc.contributor.author | Bartsch, Hauke | |
dc.contributor.author | Berg-Hansen, Pål | |
dc.contributor.author | Moen, Stine Marit | |
dc.contributor.author | Bjørnerud, Atle | |
dc.contributor.author | Westlye, Lars Tjelta | |
dc.contributor.author | Andreassen, Ole Andreas | |
dc.contributor.author | Dale, Anders | |
dc.contributor.author | Beyer, Mona K. | |
dc.date.accessioned | 2019-03-18T01:02:00Z | |
dc.date.accessioned | 2019-03-22T10:00:26Z | |
dc.date.available | 2019-03-18T01:02:00Z | |
dc.date.available | 2019-03-22T10:00:26Z | |
dc.date.issued | 2018-03-15 | |
dc.identifier.citation | Sowa PW, Harbo HFH, White NS, Celius EG, Bartsch H, Berg-Hansen PBH, Moen SM, Bjørnerud A, Westlye LT, Andreassen OA, Dale A, Beyer MK. Restriction spectrum imaging of white matter and its relation to neurological disability in multiple sclerosis. Multiple Sclerosis. 2018:1-12 | en |
dc.identifier.issn | 1352-4585 | |
dc.identifier.issn | 1352-4585 | |
dc.identifier.issn | 1477-0970 | |
dc.identifier.uri | https://hdl.handle.net/10642/6865 | |
dc.description.abstract | Background: Restriction spectrum imaging (RSI) is a recently introduced magnetic resonance imaging diffusion technique. The utility of RSI in multiple sclerosis (MS) is unknown.
Objective: To investigate the association between RSI-derived parameters and neurological disability in MS.
Methods: Seventy-seven relapsing-remitting MS patients were scanned with RSI on a 3-Tesla scanner. RSI-derived parameters: fast and slow apparent diffusion coefficient (sADC), fractional anisotropy, restricted fractional anisotropy, neurite density (ND), cellularity, extracellular water fraction and free water fraction were obtained in white matter lesions (WML) and normal appearing white matter (NAWM). Patients were divided into three groups according to their expanded disability status scale (EDSS): with minimal, low and substantial disability (<2.5, 2.5–3 and >3, respectively). Group comparisons and correlation analyses were performed.
Results: All tested RSI-derived parameters differed between WML and NAWM (p<0.001 for all pairwise comparisons). The sADC in WML showed largest difference across disability subgroups (ANOVA: F=5.1, η2=0.12 p=0.008). ND in NAWM showed strongest correlation with disability (ϱ=-0.39, p<0.001).
Conclusion: The strongest correlation with EDSS of ND obtained in NAWM indicates that processes outside lesions are important for disability in MS. Our study suggests that RSIderived parameters may help understand the “clinico-radiological paradox” and improve disease monitoring in MS. | en |
dc.description.sponsorship | This study received funding from South-Eastern Norway Regional Health Authority (project 39569). The project was also supported by grants for MRI acquisitions from the Odd Fellow’s Foundation for Multiple Sclerosis Research, Oslo MS Society, Norwegian Society of Radiology and Norwegian Research School in Medical Imaging, and by a travel grant from Ullevålfondet (Ullevål Foundation). | en |
dc.language.iso | en | en |
dc.publisher | SAGE Publications | en |
dc.relation.ispartofseries | Multiple Sclerosis; | |
dc.subject | Magnetic resonance imagings | en |
dc.subject | Multiple sclerosis | en |
dc.subject | Restriction spectrum imagings | en |
dc.subject | Neurite densities | en |
dc.subject | Neurological disabilities | en |
dc.title | Restriction spectrum imaging of white matter and its relation to neurological disability in multiple sclerosis | en |
dc.type | Journal article | en |
dc.type | Peer reviewed | en |
dc.date.updated | 2019-03-18T01:01:59Z | |
dc.description.version | acceptedVersion | en |
dc.identifier.doi | http://dx.doi.org/10.1177/1352458518765671 | |
dc.identifier.cristin | 1667292 | |
dc.source.journal | Multiple Sclerosis | |