Blar i HV - Master i Biomedisin på forfatter "Rein, Idun Dale"
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Synthetic lethality by inhibition of PARP in ATM-deficient lymphoid cells : reduced proliferation, replication induced DNA damage, G2 delay and cell death
Rein, Idun Dale (Master thesis, 2012)Cells that are deficient in proteins involved in homologous recombination repair (HRR) have been shown to be hypersensitive to PARP inhibitors. While a cell may tolerate PARP inhibition or HRR defects alone, the combination ...